ID   UTP10_ASPFU             Reviewed;        1798 AA.
AC   Q4WLI9;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 10;
GN   Name=utp10 {ECO:0000250|UniProtKB:P42945}; ORFNames=AFUA_6G13370;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1] {ECO:0000312|EMBL:EAL89175.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       Involved in ribosome biosynthesis (By similarity).
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:P42945,
CC       ECO:0000255}. Membrane {ECO:0000255}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
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DR   EMBL; AAHF01000006; EAL89175.1; -; Genomic_DNA.
DR   RefSeq; XP_751213.1; XM_746120.1.
DR   AlphaFoldDB; Q4WLI9; -.
DR   SMR; Q4WLI9; -.
DR   STRING; 746128.CADAFUBP00000135; -.
DR   PRIDE; Q4WLI9; -.
DR   EnsemblFungi; EAL89175; EAL89175; AFUA_6G13370.
DR   GeneID; 3508524; -.
DR   KEGG; afm:AFUA_6G13370; -.
DR   VEuPathDB; FungiDB:Afu6g13370; -.
DR   eggNOG; KOG1837; Eukaryota.
DR   HOGENOM; CLU_001128_3_1_1; -.
DR   InParanoid; Q4WLI9; -.
DR   OMA; NDVMWKQ; -.
DR   OrthoDB; 524830at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0034455; C:t-UTP complex; IBA:GO_Central.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012954; BP28_C_dom.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR022125; U3snoRNP10_N.
DR   InterPro; IPR040191; UTP10.
DR   PANTHER; PTHR13457; PTHR13457; 1.
DR   Pfam; PF08146; BP28CT; 1.
DR   Pfam; PF02985; HEAT; 1.
DR   Pfam; PF12397; U3snoRNP10; 1.
DR   SMART; SM01036; BP28CT; 1.
DR   SUPFAM; SSF48371; SSF48371; 3.
DR   PROSITE; PS50077; HEAT_REPEAT; 2.
PE   3: Inferred from homology;
KW   Membrane; Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing; Transmembrane; Transmembrane helix.
FT   CHAIN           1..1798
FT                   /note="U3 small nucleolar RNA-associated protein 10"
FT                   /id="PRO_0000308494"
FT   TRANSMEM        942..962
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        998..1018
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          583..620
FT                   /note="HEAT 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1042..1079
FT                   /note="HEAT 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1249..1286
FT                   /note="HEAT 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1293..1331
FT                   /note="HEAT 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1754..1791
FT                   /note="HEAT 5"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1798 AA;  198998 MW;  97D43ECD76D67662 CRC64;
     MASSLAAQLS QIAAKSTNQL DLKAQRIAHS QSLIFDRKVA SIQDFDTVYQ ICYEGFQELC
     QLDSRFTAFE RTIFSEQSKA EDRTQLTAAQ NKELDVALEA FLALVGGRLL LNPAIKAVEW
     LVRRFRIHEY NTSFTILTFL PYYTTPLFLN LLAILPEDLT PTFKVLIPYK KSSINPPRHP
     LVHSATTNKP FLAALNSYVL QVSRQQAHHH ALLAFWAGVY TEAVAGMLDA SRSGRREIEK
     QKHEDIVISV LPILNDGFAM KNVSELIIGC YMVSVVLAQK ASLQDKVLDS LMEAVAGSWT
     EETVESGLVC LAVLAQQKPE TKLPRRALKA ILRLDDIFKR LTELATQYKT SHLLLGVVAG
     CLDDLPRQKD TARLDLLSQI FQNQLLGEPE MSKAMALVLE ATSSVHKDGA MSLDAQARLA
     DLVQVFSQSE SLRPTFQKTI AESSFDIAAL EHNLQTVIDT APAPRTVEDV EMEDVEKEEE
     QDHFSSTVES LSGEKLFKGS FLSTQSIPLF EKLAQAFTLA IGSKEKCQTF SDLAALGKNE
     AEKSPQYLSF FIRVFSGPYS MGTRVTALNM ITSFLTSTES TNLDFQALLP FLLVTLTDPS
     ERVRREAAAA LAAVGSLYKK NRKGEDIWAR DNLYGQPKDI KWLPTRDAQK VFERAVLPSL
     EECIFDATHI GKVLENTLRG VSVDANASEL KKPLRLAFFT FLCSHAIELP LFTPKLGLLN
     ILNRIDKAGG TTRTKELEPL LKTWRGFSER EVQDICEKER VPVSDVERQM VAIVTPKEKD
     SIMILLSNVS SHSESLRPSF IAAVFGRIKD IWARVAEDRQ TVAAEQLFDI SLGLSDLPLV
     NNSRDLLRSV QLPGSVLAQF LERIPVSLTD MEALGPAPKR RRTSQNNMIA MTVKDEAEFG
     KVMEKMTFIL ELVDSSSPET HPELADGLFQ TLAALHHFKS QIQSGMSYLL SLTLGSLLAI
     VNRSKESAKA QFDTSVIRAD LVVDCVRTTE SPQVQNAALL LVAGLSVIAP ELVLHSVMPI
     FTFMGSSVLR KDDDYSVSVI DQTIDQVVPA LIQSLRDQKR DVVSGTSELL LSFTAAFEHI
     PSHRRLRLFH ALITKLGTQD FLFAVLAMLA NRYAMDKDVL VLMTGLVSDA SAPVELTTYS
     KFLGLVSDSL KPKPGISQVL LGIGSDDGRE PQKVAVDLLR DLAYLFKHSS LKVKMAKTFA
     SEDEEAIRQL RSTFSQILEQ VLTIGDSVQS MKLVSQANGD VLAALFGTLT LVDFLDTIEV
     LLERPNDELR RKVLRLLEGR LRQNPERDSA SQIRVLDFLP TLVDIIRNST DILLKHAAVA
     CIDRIAEKYG KKDPSRVIGA AQVVASEACI GQTDDRIRIM GVLCLASMAE TLGQVMIPAL
     PEALSRSLAL LELSLEEGKE NSRLHDAVFS LFSALFVHIP YMISGPHLDK ILLLSFKSAN
     AEECEDDSRQ EALKMMARKV DMAATLGAVD RNWQYAVQAG PVATKETLEV VSLAVEKHPK
     SATGKNIGVL SSILFKAFDL RREQLALGAN ATFDAADVDE TEDALNDVTI KMIYKLNDTT
     FRPIFTKMLD WATSGLPKKD TQGSLARLTA FYKFLQVFFG TLQSIVTGYA SYIIESVVSV
     LGKASPADKS TKALWLATMR LLRNAFEHDQ DEFWQSPSHL NQISTPLINQ LAHATNSSTA
     ATVIAEAVPA ITELAVAADS TDNHKELNTA LMKFLRPSAG PNGKPAGGEN PHTRLAALKA
     EQSLTEQLGE EWLALLPEML PYISELMEDE DENVEREVRK WVKQIENVLG EKLDDMLT