UTP10_ASPFU
ID UTP10_ASPFU Reviewed; 1798 AA.
AC Q4WLI9;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=U3 small nucleolar RNA-associated protein 10;
GN Name=utp10 {ECO:0000250|UniProtKB:P42945}; ORFNames=AFUA_6G13370;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1] {ECO:0000312|EMBL:EAL89175.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC Involved in ribosome biosynthesis (By similarity).
CC {ECO:0000250|UniProtKB:P42945}.
CC -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC {ECO:0000250|UniProtKB:P42945}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:P42945,
CC ECO:0000255}. Membrane {ECO:0000255}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
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DR EMBL; AAHF01000006; EAL89175.1; -; Genomic_DNA.
DR RefSeq; XP_751213.1; XM_746120.1.
DR AlphaFoldDB; Q4WLI9; -.
DR SMR; Q4WLI9; -.
DR STRING; 746128.CADAFUBP00000135; -.
DR PRIDE; Q4WLI9; -.
DR EnsemblFungi; EAL89175; EAL89175; AFUA_6G13370.
DR GeneID; 3508524; -.
DR KEGG; afm:AFUA_6G13370; -.
DR VEuPathDB; FungiDB:Afu6g13370; -.
DR eggNOG; KOG1837; Eukaryota.
DR HOGENOM; CLU_001128_3_1_1; -.
DR InParanoid; Q4WLI9; -.
DR OMA; NDVMWKQ; -.
DR OrthoDB; 524830at2759; -.
DR Proteomes; UP000002530; Chromosome 6.
DR GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0034455; C:t-UTP complex; IBA:GO_Central.
DR GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012954; BP28_C_dom.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR022125; U3snoRNP10_N.
DR InterPro; IPR040191; UTP10.
DR PANTHER; PTHR13457; PTHR13457; 1.
DR Pfam; PF08146; BP28CT; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF12397; U3snoRNP10; 1.
DR SMART; SM01036; BP28CT; 1.
DR SUPFAM; SSF48371; SSF48371; 3.
DR PROSITE; PS50077; HEAT_REPEAT; 2.
PE 3: Inferred from homology;
KW Membrane; Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; rRNA processing; Transmembrane; Transmembrane helix.
FT CHAIN 1..1798
FT /note="U3 small nucleolar RNA-associated protein 10"
FT /id="PRO_0000308494"
FT TRANSMEM 942..962
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 998..1018
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 583..620
FT /note="HEAT 1"
FT /evidence="ECO:0000255"
FT REPEAT 1042..1079
FT /note="HEAT 2"
FT /evidence="ECO:0000255"
FT REPEAT 1249..1286
FT /note="HEAT 3"
FT /evidence="ECO:0000255"
FT REPEAT 1293..1331
FT /note="HEAT 4"
FT /evidence="ECO:0000255"
FT REPEAT 1754..1791
FT /note="HEAT 5"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1798 AA; 198998 MW; 97D43ECD76D67662 CRC64;
MASSLAAQLS QIAAKSTNQL DLKAQRIAHS QSLIFDRKVA SIQDFDTVYQ ICYEGFQELC
QLDSRFTAFE RTIFSEQSKA EDRTQLTAAQ NKELDVALEA FLALVGGRLL LNPAIKAVEW
LVRRFRIHEY NTSFTILTFL PYYTTPLFLN LLAILPEDLT PTFKVLIPYK KSSINPPRHP
LVHSATTNKP FLAALNSYVL QVSRQQAHHH ALLAFWAGVY TEAVAGMLDA SRSGRREIEK
QKHEDIVISV LPILNDGFAM KNVSELIIGC YMVSVVLAQK ASLQDKVLDS LMEAVAGSWT
EETVESGLVC LAVLAQQKPE TKLPRRALKA ILRLDDIFKR LTELATQYKT SHLLLGVVAG
CLDDLPRQKD TARLDLLSQI FQNQLLGEPE MSKAMALVLE ATSSVHKDGA MSLDAQARLA
DLVQVFSQSE SLRPTFQKTI AESSFDIAAL EHNLQTVIDT APAPRTVEDV EMEDVEKEEE
QDHFSSTVES LSGEKLFKGS FLSTQSIPLF EKLAQAFTLA IGSKEKCQTF SDLAALGKNE
AEKSPQYLSF FIRVFSGPYS MGTRVTALNM ITSFLTSTES TNLDFQALLP FLLVTLTDPS
ERVRREAAAA LAAVGSLYKK NRKGEDIWAR DNLYGQPKDI KWLPTRDAQK VFERAVLPSL
EECIFDATHI GKVLENTLRG VSVDANASEL KKPLRLAFFT FLCSHAIELP LFTPKLGLLN
ILNRIDKAGG TTRTKELEPL LKTWRGFSER EVQDICEKER VPVSDVERQM VAIVTPKEKD
SIMILLSNVS SHSESLRPSF IAAVFGRIKD IWARVAEDRQ TVAAEQLFDI SLGLSDLPLV
NNSRDLLRSV QLPGSVLAQF LERIPVSLTD MEALGPAPKR RRTSQNNMIA MTVKDEAEFG
KVMEKMTFIL ELVDSSSPET HPELADGLFQ TLAALHHFKS QIQSGMSYLL SLTLGSLLAI
VNRSKESAKA QFDTSVIRAD LVVDCVRTTE SPQVQNAALL LVAGLSVIAP ELVLHSVMPI
FTFMGSSVLR KDDDYSVSVI DQTIDQVVPA LIQSLRDQKR DVVSGTSELL LSFTAAFEHI
PSHRRLRLFH ALITKLGTQD FLFAVLAMLA NRYAMDKDVL VLMTGLVSDA SAPVELTTYS
KFLGLVSDSL KPKPGISQVL LGIGSDDGRE PQKVAVDLLR DLAYLFKHSS LKVKMAKTFA
SEDEEAIRQL RSTFSQILEQ VLTIGDSVQS MKLVSQANGD VLAALFGTLT LVDFLDTIEV
LLERPNDELR RKVLRLLEGR LRQNPERDSA SQIRVLDFLP TLVDIIRNST DILLKHAAVA
CIDRIAEKYG KKDPSRVIGA AQVVASEACI GQTDDRIRIM GVLCLASMAE TLGQVMIPAL
PEALSRSLAL LELSLEEGKE NSRLHDAVFS LFSALFVHIP YMISGPHLDK ILLLSFKSAN
AEECEDDSRQ EALKMMARKV DMAATLGAVD RNWQYAVQAG PVATKETLEV VSLAVEKHPK
SATGKNIGVL SSILFKAFDL RREQLALGAN ATFDAADVDE TEDALNDVTI KMIYKLNDTT
FRPIFTKMLD WATSGLPKKD TQGSLARLTA FYKFLQVFFG TLQSIVTGYA SYIIESVVSV
LGKASPADKS TKALWLATMR LLRNAFEHDQ DEFWQSPSHL NQISTPLINQ LAHATNSSTA
ATVIAEAVPA ITELAVAADS TDNHKELNTA LMKFLRPSAG PNGKPAGGEN PHTRLAALKA
EQSLTEQLGE EWLALLPEML PYISELMEDE DENVEREVRK WVKQIENVLG EKLDDMLT