ID   UTP10_CANAL             Reviewed;        1818 AA.
AC   Q59ZX6; A0A1D8PFT6;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 10;
GN   Name=UTP10 {ECO:0000250|UniProtKB:P42945};
GN   OrderedLocusNames=CAALFM_C114080WA; ORFNames=CaO19.7215;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       Involved in ribosome biosynthesis (By similarity).
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:P42945,
CC       ECO:0000255}. Membrane {ECO:0000255}; Single-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP017623; AOW27008.1; -; Genomic_DNA.
DR   RefSeq; XP_715016.1; XM_709923.1.
DR   AlphaFoldDB; Q59ZX6; -.
DR   SMR; Q59ZX6; -.
DR   STRING; 237561.Q59ZX6; -.
DR   GeneID; 3643345; -.
DR   KEGG; cal:CAALFM_C114080WA; -.
DR   CGD; CAL0000180258; orf19.7215.
DR   VEuPathDB; FungiDB:C1_14080W_A; -.
DR   eggNOG; KOG1837; Eukaryota.
DR   HOGENOM; CLU_001128_3_1_1; -.
DR   InParanoid; Q59ZX6; -.
DR   OMA; YTNQLLF; -.
DR   OrthoDB; 524830at2759; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030688; C:preribosome, small subunit precursor; IEA:EnsemblFungi.
DR   GO; GO:0033553; C:rDNA heterochromatin; IEA:EnsemblFungi.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0034455; C:t-UTP complex; IBA:GO_Central.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012954; BP28_C_dom.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR022125; U3snoRNP10_N.
DR   InterPro; IPR040191; UTP10.
DR   PANTHER; PTHR13457; PTHR13457; 1.
DR   Pfam; PF08146; BP28CT; 1.
DR   Pfam; PF12397; U3snoRNP10; 1.
DR   SMART; SM01036; BP28CT; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
PE   3: Inferred from homology;
KW   Membrane; Nucleus; Reference proteome; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing; Transmembrane; Transmembrane helix.
FT   CHAIN           1..1818
FT                   /note="U3 small nucleolar RNA-associated protein 10"
FT                   /id="PRO_0000308498"
FT   TRANSMEM        568..588
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1778..1816
FT                   /note="HEAT"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1818 AA;  204337 MW;  AFE1CCDB6EBAF902 CRC64;
     MSSLASQLQS INEKTASVAL DRKQRSKLHS RSLIFDPKQA ATQDYEYIYE IATEGLEDLC
     ELDSRFNKFK STLFSETSVN LDRNLQTKDV ISQLDKNIDA FLTLVGPYYG LTSSLKAVEW
     LVRRFHANIH NAELMILTAL PYFQHPVFVK VLNVIPKQNL PQIFEWLVGY KDQLKTPPAS
     SILKAFRNDF HFFNFYSKFL NDQIKNHTVY KEQLVFYLSN TVQLLASFSK NIEELNETHI
     PVVLETTALM LLPQQKPKYS SSINSDLKLT SYSIISVLSS IFPFSADILK SLTVSILEDE
     DALKGFTKPT LIVLSQLWKH FQGNLEVIEA FKNFKIGQHE LGVLDELKNE NYQLSTFIIL
     VFISTFPSNE SYKLLPFIDL SNKTVFEIIT KLVLQNSTTQ EDSIRSNLTK IAQSLTKSDP
     KLFQTTLESE NWKVDELELK LMSVLVESKN DEAEFDAGDE DNAVEDIEIV KTVDFTKLQS
     TAKSYFNTEY DEEFNLVLKE LKSVLSASDA KLHVSVILTF LQKVFSTPEV ALTFAFRVAL
     TPAVPLSIRL SAIKSIRIKI KNAANGKTDF YLLIPLILLA LFDNSKLIRS GFAQLLRLVI
     EIKTKLTTGA ALFLEREIYG SVSDKKYPTP HDSLFLCSLL SEDNVKDTVL DPSRVINILF
     DSIFKAKNGK SKPGKYFRSF IFTQWSLCSL PIVLKANAWK IVAQANKAGT DDRFFFLDGD
     IENYFSKRNV WIDQASIAGI AFFDNAEVSV VGLVGGVASN DKNSNTESEW LCRALENPSG
     NLQMTANNRV LETFDTFKPI ESRLKIVNKL VDILINDDIV EFDPMATLQE LNIDRNLFLQ
     ALTSVQIGDQ IPEQGIAKRR RRSSNSTKQA MVRDEINNMA SGHLKKLTFL LEILESSLRK
     KRNVAGPDLL KVLFKILTDL EYLGNDGNLP VLYAQETLAS CMLLNIVNLK SSSKEVKFDS
     NSIRADLIVN SIRASPSPQV QNRLLLVISE LASLAPEVIL HSVMPIFTFM GAHTVRQDDE
     FSSSALQQTV AKVIPALASN GLSPVNNEIE FLLASFATAF PHVPRHRRVK LFVSLTKTLG
     CAESMHLILF LMGQQYANNV HKNKNGDSQS VVEFVHGYMK SFSAEEQLAG IVAFTKLWND
     IPLNQLEPGS EEFEVLNNRP VFGTTIATLG QSGLAVLRND LLQFLDETLS SENKHELSSL
     KTKMALVLID DEDSEVSKKE SVLDKFRAIT SFALASLDTF TNSHADIKLC STLYSLLGNL
     LDLLPLNYFI DSIVASLDVD TLSDSLSIKV ARNYAILASR KFETELNVAH CDQVVIESVI
     NNLLPILIKG IKKNVDVELQ QAYLDTFSTI VNKFGASGTE FASSDVSKVL IESLGIVTTD
     RGLLNEQPEV IIASINAITS IVNILGVKTL GLFPKVVPPA LKIWESTNSL GDKESAKLLQ
     GSVLVLLSCY IKKIPAFMST TLEAVLLTIL SSDLIDNHIR SSVLDLIVDH MDLAQVLKSL
     CNVWLTKKFY TNDNSGNIGL FLKTLQATIN KMEKKQATTQ ATLFMRWLIS AFEFRQYSED
     NDNKFDNNTI HRLESSFHGC AIAFVMKLND KSFRPLFANL VRWAVDGEGA TLKTNEVSRL
     LAFFRFFNKL QDELKSIITS YFSYLLDPTS ALLKRFSEGS LVATNLRRII LIGLTSSFKY
     DQDDYWSQQG RFDSICSPLL SQLSNIEDSI GKYLVKSVST FVTDVSSDEY NETLVHELIK
     YISNANENSA ATKIWSIRTL KTIFQKMGEQ WLSYLPTLVP YIAELLEDDD EEVEMEVRRG
     LVRVIENVLG EPLDRYLS