ID   UTP10_CANGA             Reviewed;        1770 AA.
AC   Q6FT93;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 10;
GN   Name=UTP10 {ECO:0000250|UniProtKB:P42945}; OrderedLocusNames=CAGL0G04411g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1] {ECO:0000312|EMBL:CAG59478.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       Involved in ribosome biosynthesis (By similarity).
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:P42945,
CC       ECO:0000255}. Membrane {ECO:0000255}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
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DR   EMBL; CR380953; CAG59478.1; -; Genomic_DNA.
DR   RefSeq; XP_446551.1; XM_446551.1.
DR   AlphaFoldDB; Q6FT93; -.
DR   SMR; Q6FT93; -.
DR   STRING; 5478.XP_446551.1; -.
DR   PRIDE; Q6FT93; -.
DR   EnsemblFungi; CAG59478; CAG59478; CAGL0G04411g.
DR   GeneID; 2888167; -.
DR   KEGG; cgr:CAGL0G04411g; -.
DR   CGD; CAL0137661; CAGL0G04411g.
DR   VEuPathDB; FungiDB:CAGL0G04411g; -.
DR   eggNOG; KOG1837; Eukaryota.
DR   HOGENOM; CLU_001128_3_1_1; -.
DR   InParanoid; Q6FT93; -.
DR   Proteomes; UP000002428; Chromosome G.
DR   GO; GO:0030686; C:90S preribosome; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030688; C:preribosome, small subunit precursor; IEA:EnsemblFungi.
DR   GO; GO:0033553; C:rDNA heterochromatin; IEA:EnsemblFungi.
DR   GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR   GO; GO:0034455; C:t-UTP complex; IEA:EnsemblFungi.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IEA:EnsemblFungi.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012954; BP28_C_dom.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR022125; U3snoRNP10_N.
DR   InterPro; IPR040191; UTP10.
DR   PANTHER; PTHR13457; PTHR13457; 1.
DR   Pfam; PF08146; BP28CT; 1.
DR   Pfam; PF12397; U3snoRNP10; 1.
DR   SMART; SM01036; BP28CT; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
PE   3: Inferred from homology;
KW   Membrane; Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing; Transmembrane; Transmembrane helix.
FT   CHAIN           1..1770
FT                   /note="U3 small nucleolar RNA-associated protein 10"
FT                   /id="PRO_0000308499"
FT   TRANSMEM        499..519
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        528..548
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1730..1768
FT                   /note="HEAT"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1770 AA;  200909 MW;  CFD1FE78D8AB9241 CRC64;
     MSSLSDQLAQ VAASNASVAF DRKKRQKLHS ASLIYNPKTA ATQDYETIFE NALGALQELC
     DIEPRFQVFS KTLFSETSIT IDRNVQSKEE NKNLDNAINA YLLMVSSKWH LAPALHATEW
     LVRRFQIHVH NTEILLLSTL NYYQSPIFKR ILNIVKLPAL FQPLSNFVKN DSNPTNITII
     KMFNDTDFLK LYSNYLSKCI KHKSTYTNQL LFVTCCFINL IAFNSSNDEK LEFLVPIILE
     IAAKLLASGS TDCQIAAHTI LIVFTAALPL KKDIVVAAIE TILANLKDKK AEQSAFWAVI
     KISQTLKGQQ AIEHLPANIY KIFDKHYTWV RVLDLLTEEP SIKCDKFMTS YIRAMIRFDH
     SKLDMVVPLV QKLSLEKYEF RSIVIDLIHL SEVLEDKSKL IDLFEFLVKE NESLVINCLS
     SLNLTGEMFE IRLTTSLFSK TNDDNELELL KTLNSHKNTS SDKKEETKPF KQFLEENSEF
     IVTSNKSMIS EDDEKFNKIL GLFIEAIGTG YQAGLFLSSF MTTLEARLTF LLRVIVSPSA
     PIALRLLAMN NISKYIQSID KELNLFTLIP FLLVAQSGSS KNLKISVKKI LGQIGNRPFT
     KHYFMSNQLY GEGKDIKVPS PSDSEMWTKN FIENYVVENV DISGVFIPKQ AEKVFLLFWA
     QQVLDIPLPY PQYMILNFLG KYVPNTASYS GLFEESISSY LERREELLLR CALNKTDPIQ
     FETAMVNLIS NKEKHHFMLD FIINVLQSDY EDLIQILVDR LVEVFATFKT SNQLRIVQEI
     LQSVTKEDQI YDALGTLQSL QIDPDTFVCI FKENSINSES DVTSFPKRRR RRSSTNKAAL
     QSAEVSQIAE DHLKKLTIML ETLDKQKVKG SEELLSSLFF TLADFETLDQ DGGLPVLYAE
     ELLASAMLNT IRSLKDQGLT QLQNVRADII VSAIRTSSSP QVQNKLLLVI GELATLSSEI
     VLHSVMPIFT FMGAHSVRQD DEFTTQVVEK TILTVVPAFL AANSENITEE IEFLVMSFAT
     ALQHIPKHRR LRLFTTLVQA LGSDNSLGPL LLLISQQYSN AVKSFKISES RSLVEFTKLL
     LSKFEVQEQI TGFRKFLELY EKLLLANKNP EKKVTLETQA LFSSKILNLT QSEFCDLTNN
     SYDFLTKVIV DTNDDYYDSS RNFKIRLYSI ILDPTVSNAT RKALDESYSS VLKMILSLIA
     DYPDIFVFET NENSEKQNSV HFIGDILEEI KQSLYGLLHA ILDVLPINVF LTTTVPLLES
     SIDKEIRYHI ASNIFDKFEN ETVDDHELTQ SVVHTLNEKI PQEENNVAQV LLNLQSSLIN
     KYGSFFDNNL LVEVLNLASG LISTGPRELQ ISSIAVITNC VSVMGVKFIS FYPKVVPICI
     KLFNETRASK EELAPQLQLS ILLLFTALVK SIPSFLTSDL ISLMKLIFFS SGVEVTTRLS
     VIQLVTEKLD LKNVLGTLLK VWNSEVKESG DSTAISLFLS LLEGTVEKIE KKSATSQSPL
     FFKLLICLFE FRSQSEFDTN TISRIESSVY AVANTYVLKL NDKVFRPLFV ILIKWAFDGE
     GVSSESITEK ERLTAFFKFF NRLQENLKGI ITSYFTYLIE PVNELLKRFI SGDISDVNLR
     RLLLNSLTSS LKYDRDEYWQ STSRFELICP SLVNQLSNIE PTIGKYLVKA IGSLAAKNSS
     VDEHNQMMNK LLVEHMKATC SSNEKLWAVR TVKLIYSKVG ESWLVLLPQM VPIIAELLED
     DNEEVESEVR GGLVRVMENV LGEPFDRYLD