ID   UTP10_COCIM             Reviewed;        1813 AA.
AC   Q1DHH9; I9NSK4;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 10;
GN   Name=UTP10 {ECO:0000250|UniProtKB:P42945}; ORFNames=CIMG_10234;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       Involved in ribosome biosynthesis (By similarity).
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
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DR   EMBL; GG704915; EAS27629.3; -; Genomic_DNA.
DR   RefSeq; XP_001239212.2; XM_001239211.2.
DR   AlphaFoldDB; Q1DHH9; -.
DR   SMR; Q1DHH9; -.
DR   STRING; 246410.Q1DHH9; -.
DR   EnsemblFungi; EAS27629; EAS27629; CIMG_10234.
DR   GeneID; 4558029; -.
DR   KEGG; cim:CIMG_10234; -.
DR   VEuPathDB; FungiDB:CIMG_10234; -.
DR   InParanoid; Q1DHH9; -.
DR   OMA; NDVMWKQ; -.
DR   OrthoDB; 524830at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012954; BP28_C_dom.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR022125; U3snoRNP10_N.
DR   InterPro; IPR040191; UTP10.
DR   PANTHER; PTHR13457; PTHR13457; 1.
DR   Pfam; PF08146; BP28CT; 1.
DR   Pfam; PF12397; U3snoRNP10; 1.
DR   SMART; SM01036; BP28CT; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..1813
FT                   /note="U3 small nucleolar RNA-associated protein 10"
FT                   /id="PRO_0000308501"
FT   REPEAT          245..283
FT                   /note="HEAT 1"
FT   REPEAT          389..427
FT                   /note="HEAT 2"
FT   REPEAT          428..464
FT                   /note="HEAT 3"
FT   REPEAT          584..621
FT                   /note="HEAT 4"
FT   REPEAT          659..695
FT                   /note="HEAT 5"
FT   REPEAT          1058..1095
FT                   /note="HEAT 6"
FT   REPEAT          1189..1228
FT                   /note="HEAT 7"
FT   REPEAT          1265..1302
FT                   /note="HEAT 8"
FT   REPEAT          1309..1347
FT                   /note="HEAT 9"
FT   REPEAT          1398..1437
FT                   /note="HEAT 10"
FT   REPEAT          1678..1715
FT                   /note="HEAT 11"
FT   REPEAT          1769..1806
FT                   /note="HEAT 12"
FT   REGION          686..705
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          887..912
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        690..705
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        895..912
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1813 AA;  201734 MW;  EB47D8D057A67A7C CRC64;
     MASSLAAQLA QIAATSTHQL DLKAQRAAHS QSLIFEKKIA GSQDFDTIFQ VCHEGFQELC
     SLDSRFLSFR RNIFSDQSKT EDRGQMTTSQ NKELDSVLED FLSLVGARLL LTPAVKAVDW
     LIRRFRVHEY NTSFLLLTFL PYHTTPLFLN FLSILPEDLT QTFKVFLPYK RSMTLPPRQV
     IVQSASTNKS FFSALNNYVL QVSKSQAHYQ GLVSFWAGIT TEALANMLDS AKSGRMEIET
     RNKEDVLIRI LPVLNDAFML RKAPQLVVGC YMLCVVLANK ASLEDHVLDN LMEAVTGSWT
     QTNFVSGITC LSVLSQQKHE KSLPSKVVKA VLRLDNVIEV FEELSGRYAV TGLIIGLIRS
     CVQENGKRSD PARIPFVGQL IQRAILSDSE TIEALTILLQ AFSDLQRQGL VADGMGKQLS
     DLLLQFNESD TLAPLLRKAI ENAGVDITQL EMTLETVLQA DIMPMEIEDA DLLDFISSSQ
     TQDAFAVALE PLSQAAITES SFLAPGSSLL FDQLAEAFIH GASTKDRVSR FIKLPVLRPD
     KPLDDPLYLS FFIRFFSGPY PVTARTVAIS IVSSCITAMA DKSADMQGIL PYIISALADP
     SERVRREAAA LLSLIDRLAS KCKDNDDSNA QIWGRGCLYG QNERSESVQF LPMKDIYKII
     HHALMPALEE YVLDPDQVGR TLTQVIRGPR SQDDSDRTRS ESTGVEFKKP LRRDLFLFLC
     SHASKTALYT VKLRLLKFLN KVGKIGSLNC TEALRQVFDQ WRLLSLEHLQ RIEDGERIST
     NELEDQVLSI IYPKDMDAVD LLFSSLTSNS RSNRESFLTA GFNRLKEVWP SLEETHELSL
     ANRLLQISLS LENGKLAGAA KGLLRSVDLS GPVILEFLNK ISASVPDLGS RGPPSKKRRT
     SQNNMVPMSS MDKETDSVLQ KMTFILELID SSHSENHPEL ISGLFQTLTI IHHLKLQTRS
     EMSYLLSLNL GILLSIVNKW KGMPTRKINT SSIRADLIID CVRTSESPQV QNTALLLVAG
     LATVAPELVL HSVMPIFTFM GSSVLRKDDE YSALVIDQTI DQVVPPLVQS LRNQKRDVVS
     GTSELLLSFT TAFEHIPSYR RLRLFEALIT KLGPEDFLFA VFAMFANRYS MDKDVLATMT
     ALASDCNAEL QLITYARYLN LVKDTLQPKP TLAKTLLGVG SEDGRDPQKI AVDLLQALSH
     LLKFTSLRTK MSECFDSGTE QQVDKAHGLF STILEQTLAL SESVRTVKPV NSACGETLGT
     LLGTLSLVDF VDTIEVLLQR PSDDLRRKVI KLLENRLDSS NDRDKASQAR VLSFLTVLIN
     ILETSPDILL KHAAVACIEK IGEKYGKKDP SQVLAAAKVI SGEHCLGQPD RRIRVMGLLC
     LASMSEILGE GIIPTLPEAL PRAIDLLRDT LAASDDDSQL HDAVYSLISA LLIHVPWMIS
     GEYLDNILQL SFISSNTDLA EGSDENRLEA LQLLAKRVDV KEAFAGVERN WDSAVTQGSR
     AVQEALDVVR TAIEKHAKSA TVKNVSVLMK LLCKAFDLRR LQLSPLNDGG FDEAEVDEIE
     SRANDVAVRM IYKLNDTVFR PLFIDLTAWA VSGLGKKDTT GRVARLTTFY RFLESFFGTL
     KSIVTGYSSY IIESAVEVLK FSRCNDKATK TLWLAVLRML RNSFGHDQDE FWQSPTHLAS
     ISEPLIKQLS MATNSPTLDL VAAEAIPTIV ELAVAADSPD NHKELNTVIM KFMRAGHGNA
     RGADNPYTRL AAVKCEQQLT ERLGEEWLAL LPEMLPYISE LLEDDDENVE REVRRWVLSI
     EDILGEKLDD MLT