UTP10_CRYNB
ID UTP10_CRYNB Reviewed; 2021 AA.
AC P0CO15; Q55NB7; Q5KBQ2;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 43.
DE RecName: Full=U3 small nucleolar RNA-associated protein 10;
GN Name=UTP10; OrderedLocusNames=CNBH1700;
OS Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=283643;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B-3501A;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC Involved in ribosome biosynthesis (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
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DR EMBL; AAEY01000042; EAL19068.1; -; Genomic_DNA.
DR RefSeq; XP_773715.1; XM_768622.1.
DR AlphaFoldDB; P0CO15; -.
DR SMR; P0CO15; -.
DR EnsemblFungi; EAL19068; EAL19068; CNBH1700.
DR GeneID; 4937690; -.
DR KEGG; cnb:CNBH1700; -.
DR VEuPathDB; FungiDB:CNBH1700; -.
DR HOGENOM; CLU_001128_0_0_1; -.
DR Proteomes; UP000001435; Chromosome 8.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012954; BP28_C_dom.
DR InterPro; IPR022125; U3snoRNP10_N.
DR InterPro; IPR040191; UTP10.
DR PANTHER; PTHR13457; PTHR13457; 1.
DR Pfam; PF08146; BP28CT; 1.
DR Pfam; PF12397; U3snoRNP10; 1.
DR SMART; SM01036; BP28CT; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
PE 3: Inferred from homology;
KW Nucleus; Repeat; Ribonucleoprotein; Ribosome biogenesis; rRNA processing.
FT CHAIN 1..2021
FT /note="U3 small nucleolar RNA-associated protein 10"
FT /id="PRO_0000410112"
FT REPEAT 837..875
FT /note="HEAT 1"
FT REPEAT 976..1014
FT /note="HEAT 2"
FT REPEAT 1281..1319
FT /note="HEAT 3"
FT REPEAT 1935..1973
FT /note="HEAT 4"
FT REPEAT 1977..2015
FT /note="HEAT 5"
SQ SEQUENCE 2021 AA; 221620 MW; 6CB0B1103628A461 CRC64;
MSSLAQQLQS IASLDAARLT SAYGAPSGKS YLFPPDVASS HDIDSIFDLA QSGFDELLSL
DPEMEEFEEE LFSESAKRTD RMVLSKEEND NLDRTLGRCL RRLGKWIRLM AGGKCIEWMV
RRFRVHEMNV DEVLRSFLPY HESPNFPRIL AIVTIPKTSP YYATFAPLVK DAQPIPRSYI
VTSISPAKDK SLVLLGDIAS MVQQAVKEGV VHHALLTFWT ATMVDLLEGA RHGKGANEGV
VKQLVESFVT LLETPKAGED VNAAVYPPLV LLTRTVPLAD EPFLAIVSSL LTPGTGSNPS
QRMLTLLVIL NDRHTWSLGL GEHATENLAK VSQLGEILVA AMDKYRFEKA LNIVVKSMLE
KPDLHAKALA TVLEHESLPT SVTELASTNL LQLGSSTDSQ EVKAACKSLL TNLRERHPSI
VDTAFLQASA SLEIDTHPVD HGLVQKPSGE VAFLDVYAAD ISSRVTGVKS VIDMAKKGEE
IESSITALEA RLSDVDENVV NALYEEPKSL LEILPVEKYI AGVKPVFWAV SPISHIIGLH
LDFISQHLLV SHPEAGKQIY ESLLFPIFLS TEKRQPLTKS QALKLLNGGF KKLDKLSTIG
PEIGKAREEG MKGAQKGNLV IAKALAGATL SSSTFEDDIS FLIAQLDSTT SSARLLAYLI
LHSLVLTLRG PRQLSTSLSI LKYLSPRLTG HSLRDLKHAD ENVNTEYMES VYKKPEETRT
TLRAIVSILA AMGKVIKPIG QIVWLSGESK AKDASYKTFA QQIYLWANIA ILPANVAHFL
LRSLLTQLGE EALLFFSSIW TSSTSPVPLR ISALKHALAF IHAYATLPTS PAAQGQPVDF
QVVLPQILIA LQDSDKDVRR VAVDVLRSVE GGEGMGDVYA LDTIYGDRSE MTQLLKSVDR
KKYIETLLEV AEEFVIDRLR LKAFHTEVLN MQSGKNRKES AHRRAIIGFL MSHVASYRAI
DPRLVLLSLL SDVHDTSILR SAIPLLASLF DDKSEESLWL SSLPDGQQAL YVQALMGSLR
VQSVSVLGEA GGEGWEFLLN LLDASKSSRF IARLRILSFK AMVGGVFSAL EAHQQIEYII
ALIQCIHALP TDDALDAVKV LEKLDIQPRV LIELIEHLSD PLETSVNRKR QRQDAADEDR
PTQAVHELIT FVDSRNWPSI PASAPLVASL MSILSALLAK RLIVKEGIDY LEQEVFGAIL
ALVERITDAQ EIQRAHVGIE VVIKVIRAST NPRTAQRALL VASELARLIP DAVLHNVMPI
FTFMGASDFQ RDDAYTFGVV EKTVSRIVPV MTQSLKEKAQ NSLELYTKSL TFLSIFTDMA
GRLPRHRTLP FFVHLVKSLG ASDYLAPVCM LLVDRATTKA GRNKESVSTA LELPANLVAA
FDVSVKTQVL GEIVQELARL IGDLSKADKE AFLSQTISEN DATDRPLRQV TYLLSFLSSI
LGQLRGKACS QALVQSAVRQ LIVLAASTSQ PVMATTDIPS NLHKTLASTM LLLSADNFLG
VTAELLSDGS EQDIIMSLGV FAERLPLIKS EVRLRCTKVI AEILKRIGGL LAASGATVNA
ALEAVKSVIK TAIAQEDGAL ASVLPTVVGC IGKVKDSAVI VAALSLVELL VRRLAARTIP
FIQSILDTSL NLIKSTKLAA TATNQAFVTL SSVIETIPTF ISSKQLNAIL ITTIDYRRVE
ETNSASLFTT LAKKIRTKSL FPVLIEAWKT VQEKGGDNEM KGFFEMLRLT LKNAAREDLP
SMLKPVFAFF LDVFDLRHRL QLKGVDTRVV NDVEESAIGS FLELVTKLNE PTFKPLFIRL
YDWAVIDLAE GKNADDGRLT ERKIVLLHVM MGLLTKFKNL LSPYMGILFP HIQELLPAFA
SGSVRSEPLW TLLLNVLGKS FEVDSGAFWT DALEIELLPQ LVAQVPLFLP IAPSPQSPRP
ISSCLANLAG STTAENVLRR LNTAVCLATR SDDPKVRLAA LDALSAIWDA QAEEMVGLVP
ETVSEFLAEL LEDESKDVEI AARGVLAKIE KVTGSLKEYL E