ID   UTP10_CRYNJ             Reviewed;        2021 AA.
AC   P0CO14; Q55NB7; Q5KBQ2;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 10;
GN   Name=UTP10; OrderedLocusNames=CNI01790;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       Involved in ribosome biosynthesis (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
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DR   EMBL; AE017349; AAW45540.1; -; Genomic_DNA.
DR   RefSeq; XP_572847.1; XM_572847.1.
DR   AlphaFoldDB; P0CO14; -.
DR   SMR; P0CO14; -.
DR   STRING; 5207.AAW45540; -.
DR   PaxDb; P0CO14; -.
DR   PRIDE; P0CO14; -.
DR   EnsemblFungi; AAW45540; AAW45540; CNI01790.
DR   GeneID; 3259411; -.
DR   KEGG; cne:CNI01790; -.
DR   VEuPathDB; FungiDB:CNI01790; -.
DR   eggNOG; KOG1837; Eukaryota.
DR   HOGENOM; CLU_001128_0_0_1; -.
DR   InParanoid; P0CO14; -.
DR   OMA; NDVMWKQ; -.
DR   OrthoDB; 524830at2759; -.
DR   Proteomes; UP000002149; Chromosome 9.
DR   GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0034455; C:t-UTP complex; IBA:GO_Central.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012954; BP28_C_dom.
DR   InterPro; IPR022125; U3snoRNP10_N.
DR   InterPro; IPR040191; UTP10.
DR   PANTHER; PTHR13457; PTHR13457; 1.
DR   Pfam; PF08146; BP28CT; 1.
DR   Pfam; PF12397; U3snoRNP10; 1.
DR   SMART; SM01036; BP28CT; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..2021
FT                   /note="U3 small nucleolar RNA-associated protein 10"
FT                   /id="PRO_0000308502"
FT   REPEAT          837..875
FT                   /note="HEAT 1"
FT   REPEAT          976..1014
FT                   /note="HEAT 2"
FT   REPEAT          1281..1319
FT                   /note="HEAT 3"
FT   REPEAT          1935..1973
FT                   /note="HEAT 4"
FT   REPEAT          1977..2015
FT                   /note="HEAT 5"
SQ   SEQUENCE   2021 AA;  221665 MW;  B4E55BCA001439F8 CRC64;
     MSSLAQQLQS IASLDAARLT SAYGAPSGKS YLFPPDVASS HDIDSIFDLA QSGFDELLSL
     DPEMEEFEEE LFSESAKRTD RMVLSKEEND NLDRTLGRCL RRLGKWIRLM AGGKCIEWMV
     RRFRVHEMNV DEVLRSFLPY HESPNFPRIL AIVTIPKTSP YYATFAPLVK NAQPIPRSYI
     VTSISPAKDK SLVLLGDIAS MVQQAVKEGV VHHALLTFWT ATMVDLLEGA RHGKGANEGV
     VKQLVESFVT LLETPKAGED VNAAVYPPLV LLTRTVPLAD EPFLAIVSSL LTPGTGSNPS
     QRMLTLLVIL NDRHTWSLGL GEHATENLAK VSQLGEILVA AMDKYRFEKA LNIVVKSMLE
     KPDLHAKALA TVLEHESLPT SVTELASTNL LQLGSSTDSQ EVKAACKSLL TNLRERHPSI
     VDTAFLQASA SLEIDTHPVD HGLVQKPSGE VAFLDVYAAD ISSRVTGVKS VIDMAKKGEE
     IESSITALEA RLSDVDENVV NALYEEPKSL LEILPVEKYI AGVKPVFWAV SPISHIIGLH
     LDFISQHLLV SHPEAGKQIY ESLLFPIFLS TEKRQPLTKS QALKLLNGGF KKLDKLSTIG
     PEIGKAREEG MKGAQKGNLV IAKALAGATL SSSTFEDDIS FLIAQLDSTT SSARLLAYLI
     LHSLVLTLRG PRQLSTSLSI LKYLSPRLTG HSLRDLKHAD ENVNTEYMES VYKKPEETRT
     TLRAIVSILA AMGKVIKPIG QIVWLSGESK AKDASYKTFA QQIYLWANIA ILPANVAHFL
     LRSLLTQLGE EALLFFSSIW TSSTSPVPLR ISALKHALAF IHAYATLPTS PAAQGQPVDF
     QVVLPQILIA LQDSDKDVRR VAVDVLRSVE GGEGMGDVYA LDTIYGDRSE MTQLLKSVDR
     KKYIETLLEV AEEFVIDRLR LKAFHTEVLN MQSGKNRKES AHRRAIIGFL MSHVASYRAI
     DPRLVLLSLL SDVHDTSILR SAIPLLASLF DDKSEESLWL SSLPDGQQAL YVQALMGSLR
     VQSVSVLGEA GGEGWEFLLN LLDASKSSRF IARLRILSFK AMVGGVFSAL EAHQQIEYII
     ALIQCIHALP TDDALDAVKV LEKLDIQPRV LIELIEHLSD PLETSVNRKR QRQDAADEDR
     PTQAVHELIT FVDSRNWPSI PASAPLVASL MSILSALLAK RLIVKEGIDY LEQEVFGAIL
     ALVERITDAQ EIQRAHVGIE VVIKVIRAST NPRTAQRALL VASELARLIP DAVLHNVMPI
     FTFMGASDFQ RDDAYTFGVV EKTVSRIVPV MTQSLKEKAQ NSLELYTKSL TFLSIFTDMA
     GRLPRHRTLP FFVHLVKSLG ASDYLAPVCM LLVDRATTKA GRNKESVSTA LELPANLVAA
     FDVSVKTQVL GEIVQELARL IGDLSKADKE AFLSQTISEN DATDRPLRQV TYLLSFLSSI
     LGQLRGKACS QALVQSAVRQ LIVLAASTSQ PVMATTDIPS NLHKTLASTM LLLSADNFLG
     VTAELLSDGS EQDIIMSLGV FAERLPLIKS EVRLRCTKVI AEILKRIGDL LAASGATVNA
     ALEAVKSVTK TAIAQEDGAL ASVLPTVVGC IGKVKDSAVI VAALSLVELL VRRLAARTIP
     FIQSILDTSL NLIKSTKLAA TATNQAFVTL SSVIETIPTF ISSKQLNAIL ITTIDYRRVE
     ETNSASLFTT LAKKIRTKSL FPVLIEAWKT VQEKGGDNEM KGFFEMLRLT LKNAAREDLP
     SMLKPVFAFF LDVFDLRHRL QLKGVDTRVV NDVEESAIGS FLELVTKLNE PTFKPLFIRL
     YDWAVIDLAE GKNADDGRLT ERKIVLLHVM MGLLTKFKNL LSPYMGILFP HIQELLPAFA
     SGSVRSEPLW TLLLNVLGKS FEVDSGAFWT DALEIELLPQ LVAQVPLFLP IAPSPQSPRP
     ISSCLANLAG STTAENVLRR LNTAVCLATR SDDPKVRLAA LDALSAIWDA QAEEMVGLVP
     ETVSEFLAEL LEDESKDVEI AARGVLAKIE KVTGSLKEYL E