ID   UTP10_DEBHA             Reviewed;        1857 AA.
AC   Q6BXQ6;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 10;
GN   Name=UTP10 {ECO:0000250|UniProtKB:P42945}; OrderedLocusNames=DEHA2B01100g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       Involved in ribosome biosynthesis (By similarity).
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:P42945,
CC       ECO:0000255}. Membrane {ECO:0000255}; Single-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
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DR   EMBL; CR382134; CAG84998.2; -; Genomic_DNA.
DR   RefSeq; XP_457013.2; XM_457013.1.
DR   AlphaFoldDB; Q6BXQ6; -.
DR   SMR; Q6BXQ6; -.
DR   STRING; 4959.XP_457013.2; -.
DR   EnsemblFungi; CAG84998; CAG84998; DEHA2B01100g.
DR   GeneID; 2913152; -.
DR   KEGG; dha:DEHA2B01100g; -.
DR   VEuPathDB; FungiDB:DEHA2B01100g; -.
DR   eggNOG; KOG1837; Eukaryota.
DR   HOGENOM; CLU_001128_3_1_1; -.
DR   InParanoid; Q6BXQ6; -.
DR   OMA; YTNQLLF; -.
DR   OrthoDB; 524830at2759; -.
DR   Proteomes; UP000000599; Chromosome B.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012954; BP28_C_dom.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR022125; U3snoRNP10_N.
DR   InterPro; IPR040191; UTP10.
DR   PANTHER; PTHR13457; PTHR13457; 1.
DR   Pfam; PF08146; BP28CT; 1.
DR   Pfam; PF12397; U3snoRNP10; 1.
DR   SMART; SM01036; BP28CT; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
PE   3: Inferred from homology;
KW   Membrane; Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing; Transmembrane; Transmembrane helix.
FT   CHAIN           1..1857
FT                   /note="U3 small nucleolar RNA-associated protein 10"
FT                   /id="PRO_0000308503"
FT   TRANSMEM        267..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1817..1855
FT                   /note="HEAT"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1857 AA;  210524 MW;  967532DBF8285D59 CRC64;
     MSSLSQQLKS INEKTASVAL DRKSRSKIHS KSLIFDPKIA STQDYDYLYQ IGLEGLEDLI
     EIDSRFSKFK QTLFSETTIN LDRNVQTQDT LDQLNKNVEV FLSLVSPYYL LTPSTKAVEW
     LIRRFYINIH NGEMLLLTSL PFYNSPVFVK ILNVIPKNQF PKIFEWVVGY KDLLKSPTSS
     SILKSFHNDA KFFELYSKYL MDQLNNHAVF KEQLVFYLAN TVQLVASFTH NLGQFGETYL
     PVILEVVGKL LLAGSKFSST LRNDIMLTAY SIISVLSSLV PLSADLVKSF TESILQDPTA
     CDSNTRKQTV IVLGQLWNFY NEDNFEVDCF KNLPASKLVQ DDLLKNLIEE GYKINKLLVV
     YFASNLPQID AFKIFDFINV DKSETFFKIV TSKLLYYAYN NQDEAIRAKL IEAFESLLRT
     NKELFVKVLQ NYKDGLDISQ LEMQLMTTLG DSNIENIHDA DIELEDEEEE EEEDQAVLDV
     DFSDVCNSLE NYKTSTTSFL NKSSDEEFTK LFQAFAEKSR SFNIKSQKLI LAKFSKAIFV
     SPEASISFML RVSFTPSVPL SIRLLVLRFI KLRLKELSLS EDKIDTYLLA PILLLGLYDT
     NKSVRAGFAE LLRVVKDTTS KFHGNKKKVK TSLFMEDQIY GNTEPSKRAI VPPQDGLEML
     NVLIEDSKSI LDDTVIDKSR LNYVLFQVLF KSQKSGQKKF GQLLLKTFIL NQWTLPFWPI
     VFKYKVWNII SIENNSNGGN DDRFFFIDTD LTDYFSNRDD LIEQAKASKI DFENDVEKAI
     VGLVGGTSSN DKNVNKEADW LLKALEAPNK LQVAAGKRLS SVFTSFTSID MRAKLVNKLI
     ELLINDGDDS DNLVVDPVEV LQLLDMDHET IISVLRNVQI VSQIPEQGIV KRRRRSSNST
     KQAMARDDIS SIAATHLKKL TIVLDLLEFN LRKKTSDIAK PDLLQNLFRI LTDLDYLGND
     GNLPILYAQE TLASCMLLSI VQMKDNSKSN SFKFDSNVVR ADLIVNSIRL SQSPQVQNRL
     LLVIAELAAL APEIILHSVM PIFTFMGAHT VRQDDEFSSS ALQQTIAKVI PALAANGSSS
     LSYEIEFLLT SFVAAFQHIP RHRRVKLFTS LTKTLSYKHS LHIILFLMGQ QYSNNITRNK
     AHESISILEF TSAFLKNFSA QEQLEGVEKF YQLWNQIPNA QLEPNSDEFN ALSSRSIFGV
     SILSLSKSGL LTFKSQLLNF IDKVLDSDTQ NDFSNLPSLK LKIALILLDP KKPAEDKSDL
     LNYFRKVTSF ILSSLDTFTN VSRNDVLLDN LYALLGNFLD LLPLNYFIDS IIDSLDCDQI
     SNTLEIKIAK NFAILASRKI ENELNANNID DVIEESILQK LLPVLNKGIK KNLDIELQQA
     YLNAFSSIVN KFGGSTHLLV TQGNTEALIN SLNIITSNSG LLSEQPEIVI SSINAITSIV
     NVLGVKAIGL FPKIVPPSLN IWKTTTASED ESSKLLQASI ILLLACLIKK IPVFMTTSLD
     SIFITILTSD SVDNTVRSSV LQLIVEHMEL SQVLKSLCNI WNNKKFYQND NAGNLGLYLN
     VLQSTIERMD KKSASSQSTL FMKWLIQAFE FRHYAFDENN KFDNNTIHRL ESSFHSCGAS
     YVMKLNDKSF RPLFANLVRW AVSGEGSNAT GNTELSRLLA FFKFFSKLQD KLKSIITSYF
     SYLIDPVSSI LNRFANGDIV DINLRRILLN SLTSSFKYDQ DDYWSQQSRF DSICSPLLNQ
     LSNIEPNIGK YLVKCVSSFI SNVSSEEYNE KLVHGLIEFI SNENESTTSN TKIWTIRTLK
     TIFQKMGEQW LSYLPTLIPY IAELLEDDDE EVELEVRNGL VRVIENVLGE PLDRYLD