ID   UTP10_EMENI             Reviewed;        1801 AA.
AC   Q5B1X5; C8VGG5;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 10;
GN   Name=utp10 {ECO:0000250|UniProtKB:P42945}; ORFNames=AN5455;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1] {ECO:0000312|EMBL:EAA62615.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       Involved in ribosome biosynthesis (By similarity).
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:P42945,
CC       ECO:0000255}. Membrane {ECO:0000255}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
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DR   EMBL; AACD01000094; EAA62615.1; -; Genomic_DNA.
DR   EMBL; BN001305; CBF81880.1; -; Genomic_DNA.
DR   RefSeq; XP_663059.1; XM_657967.1.
DR   AlphaFoldDB; Q5B1X5; -.
DR   SMR; Q5B1X5; -.
DR   STRING; 162425.CADANIAP00003634; -.
DR   PRIDE; Q5B1X5; -.
DR   EnsemblFungi; CBF81880; CBF81880; ANIA_05455.
DR   EnsemblFungi; EAA62615; EAA62615; AN5455.2.
DR   GeneID; 2871748; -.
DR   KEGG; ani:AN5455.2; -.
DR   VEuPathDB; FungiDB:AN5455; -.
DR   eggNOG; KOG1837; Eukaryota.
DR   HOGENOM; CLU_001128_3_1_1; -.
DR   InParanoid; Q5B1X5; -.
DR   OMA; NDVMWKQ; -.
DR   OrthoDB; 524830at2759; -.
DR   Proteomes; UP000000560; Chromosome V.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0034455; C:t-UTP complex; IBA:GO_Central.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012954; BP28_C_dom.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR022125; U3snoRNP10_N.
DR   InterPro; IPR040191; UTP10.
DR   PANTHER; PTHR13457; PTHR13457; 1.
DR   Pfam; PF08146; BP28CT; 1.
DR   Pfam; PF12397; U3snoRNP10; 1.
DR   SMART; SM01036; BP28CT; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
PE   3: Inferred from homology;
KW   Membrane; Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing; Transmembrane; Transmembrane helix.
FT   CHAIN           1..1801
FT                   /note="U3 small nucleolar RNA-associated protein 10"
FT                   /id="PRO_0000308504"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        939..959
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        995..1015
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          581..619
FT                   /note="HEAT 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1038..1076
FT                   /note="HEAT 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1110..1148
FT                   /note="HEAT 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1244..1282
FT                   /note="HEAT 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1288..1327
FT                   /note="HEAT 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1756..1794
FT                   /note="HEAT 6"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1801 AA;  198724 MW;  C7F6799298825024 CRC64;
     MASSLAAQLS QIAANSTNQL NLKAQRLAHS KSLIFDKRVA GSQDFDTIYD ICYDGFRELC
     QLDFRFAQFE RSIFSEQSKV QDRTEMNVEQ NRELDSVLEA FLALVGGRLL LSPAVKAVEW
     LIRRFRVHEY NTRFTILTFL PYYSTPVFLN LLAILPDDLP SALKVLIPYK RSAINPVRQA
     LVQNAISNRD LITTLNNYVL QVCRQRAHHH ALLAFWAGII TEGVAGMLDS SRSGRRNVEK
     QKHDDIILQI LPVLNDGFAM KDVSELVIGC YMVCVVLAQK AELQDRVLDG LMEAVTGSWT
     EETMSSGLIC VAVLAQQKPD PILPKRVFKA MLRMKDPLKQ LADISTEYKT SQLLLGLVAG
     CVDSLSTQKD SARLELLSSM FKSQLLNDAD TAKAMTFVLQ AASAVGGTIS LDTQTQIAEI
     VQHFSRSSSL QPVFQKVIDE SSIDLSVIEY NLQTVIESVP VNKAIEDVEM EDADKTETAT
     DGYDSALESL AKESSFSTSF LTAQSIPVFD KLVQTFALSA GSPERVSAFV ELPVLCKANA
     TTSPQFLSFF VRVFTGMYPA GVKAAALKTI SSIVSSAAWS DVDVQALLPF MLIALADPSE
     RVRSGAVDAL ANIGKVVDKK KKSGVWARDS LYGKSMHIPW LSSSDFQKIL ERAVLPELEE
     CRSDGEHIGR ALENALRGAA SDSASAIKKP LRLAFFTYLC SHAVHLPLFA PRAGLLNLLN
     RVDKAGGTTR TKELEPLLKK WRDMSEQEVA EVHEKEQISV SDFEAQVLKT VTPKEKDSIN
     LLLSTVTPYS PSLRASFVSS VFNRISEIWG KVPEDRQITA AEKLFELSTQ ASESPLVDNA
     RDLLRRVELP GPVLLNYLQQ IPASITDIDS LGPAPKRRRT SQNNMVAMTT KDEAKLSKLM
     DKMTFILELV DGSSPEAHPE LTEWLFQTLA ALHHFKSQIQ SGMSYLLSLT LGSLLAIVNR
     SRASSKPQFD TSVVRADLVV DCVRTTESPQ VQNTALLLVA GLSVIAPELV LHSVMPIFTF
     MGSSVLRKDD DYSVSVIDQT IDQVVPALIQ SLRHQKRDVV SGTSELLLSF TAAFEHIPSH
     RRLRLFHALI TKLGTEEFLF AVLAMLANRY SMDKAVLVLM TGLVSDADAT VELSTYSKFL
     NLVGDSLKSK PGISQVLLGI GSDDGREPHK VAADLLRALA YLFKHSSLKV KIARALTTET
     DDSERIRALF SNILEQVLAI GESMQSVKPV HQAAGDVLSG LFSTLTTIDF LDTIEALLKR
     PDDALRRKVL SLLATRLQQS PERDGASQTR MLDFLTVLVD IVQSSPDILL KHAAVTCIDR
     ITEKYGKKEP SMVTSAAQVV ASASCIGQED DRIRINGVLC LASMVEVLGQ AMIPALPEVL
     NRSLALLELS LETNKVNARL HDAVFTLFSA LFVHLPYMVS ASHLDRLLVL SFKSAASDED
     LDNENRQEAL HFMARKVDMA VALASIERNW TQAVSAGPSA THEVLDAISL SIEKHPKSAT
     MKNLSVLTTI LFRAFDLRRE QTQSSESAFD ASDLEEIEDL INDVTIKMIY KLNDTAFRPI
     FIKLVEWATG LPEKNTQGGL ARLTTFYRFL QVFFGTLQSI VTGYASYIIE SVVSVLETAS
     PSNPNTKSLW LATMRMLRSA FEHDQDEFWQ SPSHITKIST PLISHLRHAT STTTGALVAT
     ETIPTITELA VAADSTDNHK ELNTVLMRFL RPSSASLSSS STKRAGPGLG GDNPQTRIAA
     LKTEQALTEH LGEDWLALLP EMLPYISELM EDEDEGVERE VRKWVKQIEG VLGERLDDML
     T