ID   UTP10_KLULA             Reviewed;        1774 AA.
AC   Q6CJ57;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 10;
GN   Name=UTP10 {ECO:0000250|UniProtKB:P42945}; OrderedLocusNames=KLLA0F21208g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1] {ECO:0000312|EMBL:CAG98740.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       Involved in ribosome biosynthesis (By similarity).
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382126; CAG98740.1; -; Genomic_DNA.
DR   RefSeq; XP_456032.1; XM_456032.1.
DR   AlphaFoldDB; Q6CJ57; -.
DR   SMR; Q6CJ57; -.
DR   STRING; 28985.XP_456032.1; -.
DR   PRIDE; Q6CJ57; -.
DR   EnsemblFungi; CAG98740; CAG98740; KLLA0_F21208g.
DR   GeneID; 2895438; -.
DR   KEGG; kla:KLLA0_F21208g; -.
DR   eggNOG; KOG1837; Eukaryota.
DR   HOGENOM; CLU_001128_3_1_1; -.
DR   InParanoid; Q6CJ57; -.
DR   OMA; YTNQLLF; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0030686; C:90S preribosome; IEA:EnsemblFungi.
DR   GO; GO:0030688; C:preribosome, small subunit precursor; IEA:EnsemblFungi.
DR   GO; GO:0033553; C:rDNA heterochromatin; IEA:EnsemblFungi.
DR   GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR   GO; GO:0034455; C:t-UTP complex; IEA:EnsemblFungi.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IEA:EnsemblFungi.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012954; BP28_C_dom.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR022125; U3snoRNP10_N.
DR   InterPro; IPR040191; UTP10.
DR   PANTHER; PTHR13457; PTHR13457; 1.
DR   Pfam; PF08146; BP28CT; 1.
DR   Pfam; PF12397; U3snoRNP10; 1.
DR   SMART; SM01036; BP28CT; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..1774
FT                   /note="U3 small nucleolar RNA-associated protein 10"
FT                   /id="PRO_0000308505"
FT   REPEAT          1734..1772
FT                   /note="HEAT"
FT                   /evidence="ECO:0000255"
FT   REGION          1206..1226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1774 AA;  201062 MW;  DDAA95E6F63321B1 CRC64;
     MSSLRDQLAQ VAQNNATVAL DRKRRQKLHS ASLVYNPKTA ATQDYEYIYD TALESFHTLV
     SLDLRFKVFT NSLFSASSVT IDRNVQTKDQ IRDLDNAVNA YLMLISPKWH LTPALHATEW
     LIRRFQIHIH NAEMLLLSTL NQYQTPVFKR ILNIVKLPPL FNPFTNFVRN DKNPTDLTLI
     KLFNDMDFLK LYSNYLSKII KQKVTYTNQL LFTTCCFINV IAFNANDEDK LNKLVPLILE
     ISAKLLASDS SDCQMAAHTM LAVLATALPL NKSIIIAATE TILANLKEDD ARKKALVTIS
     KLFQTLKGVG NVDQLPVKIY KLVDNSFPFE YLLQFLSNEN KYSSDKFFTA YIRSVIRYDH
     DKLSQIVKIL RKIKLEKYEV RFIITDLIHL SEVLEDKSQL IDVFEYFISI NEGLVLKCLQ
     ALNLTGEVFE IRLTTSLFSV KNSAEQSGED IIKVLDDAKA STANGSAVPF KDFMTKNSEF
     ISTKAESMLL VKDEKFVKLL SLFVEAVSKG YQPGLFLSSF FTTLESRITF VLRIIVSPGS
     PVALRLISLT QLSKFINGID EQTDLFSLVP ILVTALMDIS RSVRSNTKKV LQQIAKRPFT
     AKYFLSNVLY GENLKVPMLS PKDSKFWLTN FLSDYIVEST DISSLVIPSK NDMVYMLFWC
     NQALHLPLAY SKTIMLKLLT AVPQYAFTYS KVFEQFMATY ITERSSWETK CIKNKTNFKD
     FETAVCAIVA PKEKNSFAID FLINCLESEY EQLSNIMADR ILSLYPTLKF PNQLKIVQSI
     IDSSVDKELS YDGLETLQSL PLTADIFVSV LKSNTINSED QTDLTKRRRR RSSTVNKSAL
     QKQDISQIAE AHLKKMTIIL ETLDKLKVKS NENLLNALFN LLSDLETLDH DGGLPVLYAQ
     ETLSSCLLNT ISSLKSNNGS MKLPSIRADI LVAAIRSSTS PQMQNKLLLV VGALASVSPE
     TILHSVMPIF TFMGAHTIRQ DDEFSTLVVE RTISTIVPAL LKSTEVTNKS DEIEFLLMSF
     STAFSHVPKH RRVSLYSTLV RELGPSDVIA PFLFLIAQQY SNCLEKFKIA ESKNYIEFFK
     AFLSKFDILE QLHGFNELFN LVELLDEDSS KNEVAPTRTL FSNGIVNMSK SELFVLKKND
     LDFIDKVIGE SKSDYYNTSS NLKLRILSTL LDPNIEIEVK NQVRNEFSIL LSKTLNAINM
     TDSLSYDKHS SAGSNDEEAG SESEAEVDQK ELKDILFGLL EHVLDLLPIQ DFVASILPLL
     QGNTDESVRH HLTVVTSNKF IEEPMESFET ANEILSTLVE TTEKASESTQ ILQVTLNTIS
     SIVTRFGDRL DSHLLVKSME NSCKQLTSKK IELEISSLTV LTTLIQTLGV KTLAFYPKIV
     PVAISIFKTY QNAKNNLKEQ LQLAIVLLFA SMIKKIPSFL LSNLQDVFVI LFHSDEVADS
     VRLSVISLIV EHIPLKDVFK TLQKVWTNDV SSSNNSVAVS LFLSMLESAV EAIDKKSATQ
     QSPVFFRLLL NLFEYRSICT FDENSINRIE ASVHQIANVY VLKLNDKVFR PLFALVVNWA
     FNGEGVTNTN MSKEERLMAF YKFYNKTQEN LKSIITSYFT YLLEPTNNLL KQFISKETVN
     VSLRRLVLIS LTSSFKYDRD EYWKSTSRFE LISESLINQL TNVEDVIGKY LVKAIGSLAT
     NNSGVDEHNK IMSDLMISHM KTSCKTREKF WAVRSMKLIY SKVGDGWLVL LPRLVPIIAE
     LLEDEDEEVE YEVRSGLVKV VESVMGEPFD RYLS