ID   UTP10_LODEL             Reviewed;        1859 AA.
AC   A5E212; A5E211; A5E213;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 10;
GN   Name=UTP10 {ECO:0000250|UniProtKB:P42945};
GN   ORFNames=LELG_03648/LELG_03649/LELG_03650;
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC   YB-4239;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       Involved in ribosome biosynthesis (By similarity).
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:P42945,
CC       ECO:0000255}. Membrane {ECO:0000255}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDK45469.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=EDK45470.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=EDK45471.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH981527; EDK45469.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CH981527; EDK45470.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CH981527; EDK45471.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001525720.1; XM_001525670.1.
DR   RefSeq; XP_001525721.1; XM_001525671.1.
DR   RefSeq; XP_001525722.1; XM_001525672.1.
DR   AlphaFoldDB; A5E212; -.
DR   SMR; A5E212; -.
DR   STRING; 379508.A5E212; -.
DR   EnsemblFungi; EDK45469; EDK45469; LELG_03648.
DR   EnsemblFungi; EDK45470; EDK45470; LELG_03649.
DR   EnsemblFungi; EDK45471; EDK45471; LELG_03650.
DR   GeneID; 5232293; -.
DR   GeneID; 5232863; -.
DR   GeneID; 5232884; -.
DR   KEGG; lel:LELG_03648; -.
DR   KEGG; lel:LELG_03649; -.
DR   KEGG; lel:LELG_03650; -.
DR   eggNOG; KOG1837; Eukaryota.
DR   HOGENOM; CLU_1111577_0_0_1; -.
DR   InParanoid; A5E212; -.
DR   OrthoDB; 524830at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012954; BP28_C_dom.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR022125; U3snoRNP10_N.
DR   InterPro; IPR040191; UTP10.
DR   PANTHER; PTHR13457; PTHR13457; 1.
DR   Pfam; PF08146; BP28CT; 1.
DR   Pfam; PF12397; U3snoRNP10; 1.
DR   SMART; SM01036; BP28CT; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
PE   3: Inferred from homology;
KW   Membrane; Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing; Transmembrane; Transmembrane helix.
FT   CHAIN           1..1859
FT                   /note="U3 small nucleolar RNA-associated protein 10"
FT                   /id="PRO_0000308506"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1392..1412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          578..616
FT                   /note="HEAT 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1819..1857
FT                   /note="HEAT 2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1859 AA;  210292 MW;  9ACFD487F206C66D CRC64;
     MSSLASQLKS ISDKSASIAL NRQQRSKIHS RSLIFDPKVA ASQDYDEIYD VAIDALDELC
     ELDSRFNKFK NSLFANDSIN FDRNVQSEDV VTQLDQNINA FFTLLGPYYN FTAALRASEW
     LVRRFQANMH NLEYMILTAL PYYMQPVFIK ILNVIPKQNI PQIFEWLVTA KDQLRSPTLQ
     VCFRAFFNDN HLFTFYSSFL DEQIKRNTTY KEQLVFYLSI TIQLLPASNK NTLNETLIPV
     VLRSSDLMLT SKNSSLRLGA YSVLAVLSAV APLSIELLNT LTFAVLANDI ALEAQFAKQT
     VFLLIQLWTS TTELTTSEAL SKTPSLPINI IEHIDISQAK KDKFLAIYFS SIFPSETSLQ
     LLNMIELKGN KRMFKFVVHT VLSSLKPQHL NGGVTSNNNS TNYKDTILDI VRKLIKLDQA
     TFDEMLKSFR LTVSELELTL EGSLLATHSG DEKLDEFGDN VDRDDDTEYT KFVDERQDDK
     EDGDENTKFD ISKLGASAPT YLDSKYNPEF YKLSFAFTRF CSKVDIKSQR AAILHFTHKV
     FQNPALSITF FVKSGIIFGC SIYMVKNTAD GKTDFYLVLP LLLIAFNDPS SHIRAAFAQL
     VQLVSEITKA IHENKKKQKT LLFFESEVYA NSAEKKMISP QDAIKLFAFI GSLDGMRLEE
     GKIATLLKSI FNGKFDKKTL GSLYQTFILN QWAQPSLPIV IKQRVWSISS QLNEMGVNGV
     RTYFWDTDIK PYLAKREEWL VQAKEAKLAD YYNIVEKSLV QLVGGDHLSA EDSNSVSHWL
     CQALDSNTSL QLVANERITS IFPKLTSVES KVIILSKLVD LLVSDDYVEF DPMITLQSLP
     LDSAVFLQIL ENVKIGDQMP EQGVVKRRRR SSSSTKQAMA KSDMTNLASQ HLRKLSIILE
     VLEVNLRKAS IANPKLLKVL FKILSDLDYL GNDGNLPILY AQEVLASCLL LSISELKNSN
     HKHQLDSNSV RADLIVNSLR NSSSPQVQNR LLLVISELAT LAPEIILHSV MPIFTFMGAH
     TIRQDDEFSN DALQKTVARV IPALASTNSG SFTTEIEFLL ASFTAAFKHI PSHRRVRLFV
     ALTKTLKPSN SMHILIYLLG EQYYQAKMQK NALEMRDIET FVTAYLKAFA VETQLNGLDQ
     FSNLLNELPR HQLEENSKIY DQLRSRPIFG LAVVNSTTEE LLKKRHALLE YLNSVLELDS
     ANFDVTSLKS RIDIALKESS ENDTLVLPQI RHMTSFALSE LDIYTNTEPH PEISAELFVM
     LTSLVDLLPV VKFVESITEF LDVDKLGDNT AIKVGRNYAV LAARKFENEI SLTLESVVEN
     FSDLDKLFIV LLKGIERNVD LELQQAYLNL FAVITSKLGV DAGLTAKFSS VLIKSLGVIT
     TSSGLLSSES EIVIASISAI VSIVNVLGIK TLGLFPKIIP PTLKIWEQTT TTTTATTTRS
     ISATKIGRDE QNESSKLVQE SVLLLLSCYI KKMPSFMVTT LDSVILTILN SDLTESQIKS
     SIMNLIIDRV NIGQVFKSLC SVWTQRQFYQ SKNPASLGLY LNSMESTINK LEKREAISEA
     TVFMKWLIQA FEFRDYSEKL GPPIRYQHYS SYGKFFPFVC YCLCHETQRM ESSFHSCAIA
     YVMKLNDKSF RPLFANLVRW AIDGDNSIHD VAKTSRLLSF YRFFNKLQEL LKSIVTSYYS
     YLVDATSECL KSFASEEDKG NKDATTLRRI VLISLSLSFT FDQDEYWSQQ GRFDSICQPL
     LDQLSNIEES IGKFLVKTIT NFVSDISSKE HSEVVLKGLV KFISYDTENL SNTKIWTIRT
     LKSIFQKMGE QWLSYLPILV PHIAELLEDD DEAVEIEVRE GLVRVIEKVL GEPLDRYLS