ID   UTP10_NEOFI             Reviewed;        1814 AA.
AC   A1DP58;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 10;
GN   Name=utp10 {ECO:0000250|UniProtKB:P42945}; ORFNames=NFIA_059300;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       Involved in ribosome biosynthesis (By similarity).
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:P42945,
CC       ECO:0000255}. Membrane {ECO:0000255}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
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DR   EMBL; DS027698; EAW16579.1; -; Genomic_DNA.
DR   RefSeq; XP_001258476.1; XM_001258475.1.
DR   AlphaFoldDB; A1DP58; -.
DR   SMR; A1DP58; -.
DR   STRING; 36630.CADNFIAP00004566; -.
DR   PRIDE; A1DP58; -.
DR   EnsemblFungi; EAW16579; EAW16579; NFIA_059300.
DR   GeneID; 4584992; -.
DR   KEGG; nfi:NFIA_059300; -.
DR   VEuPathDB; FungiDB:NFIA_059300; -.
DR   eggNOG; KOG1837; Eukaryota.
DR   HOGENOM; CLU_001128_3_1_1; -.
DR   OMA; NDVMWKQ; -.
DR   OrthoDB; 524830at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012954; BP28_C_dom.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR022125; U3snoRNP10_N.
DR   InterPro; IPR040191; UTP10.
DR   PANTHER; PTHR13457; PTHR13457; 1.
DR   Pfam; PF08146; BP28CT; 1.
DR   Pfam; PF12397; U3snoRNP10; 1.
DR   SMART; SM01036; BP28CT; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
DR   PROSITE; PS50077; HEAT_REPEAT; 2.
PE   3: Inferred from homology;
KW   Membrane; Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing; Transmembrane; Transmembrane helix.
FT   CHAIN           1..1814
FT                   /note="U3 small nucleolar RNA-associated protein 10"
FT                   /id="PRO_0000308508"
FT   TRANSMEM        942..962
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        998..1018
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          583..620
FT                   /note="HEAT 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1042..1079
FT                   /note="HEAT 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1249..1286
FT                   /note="HEAT 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1293..1331
FT                   /note="HEAT 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1770..1807
FT                   /note="HEAT 5"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1814 AA;  200465 MW;  C6FF629093A4BB8E CRC64;
     MASSLAAQLS QIAAKSTNQL DLKAQRTAHS QSLIFDRKVA STQDFDTVYQ ICYEGFQELC
     QLDSRFTAFE RTIFSEQSKA EDRTQLTAAQ NKELDVALEA FLALVGGRLL LNPAVKAVEW
     LVRRFRIHEY NTSFTILTFL PYYTTPLFLN LLAILPEDLT PTFKVLIPYK KGSINPPRHP
     LVHSATTNKP FLAALNSYVL QVSRQQAHHH ALLAFWAGIY TEAVAGMLDA SRSGRREVEK
     QKHEDIVIRV LPILNDGFAM KNVSELVIGC YMVSVVLAQK ASLQDKVLDG LMEAVAGSWT
     EETIESGLVC LAVLAQQKPE TKLPRRALKA ILRLDDVLKR LTEIATQYKT SHLLLGVVAG
     CLDDLPRQKD TARLDLLSRI FQNQLLGEPE MSKAMTLVLE ATSSVHKDGA MSLDAQARLA
     DLVQVFSQSE SLQPTFQKTI AESSFDIAAL EHNLQTVIDT APAPRTVEDV EMEDVEKEEE
     QDNFSSAVES LSGEKLFKGS FLSTQSIPLF ERLAQAFTLA VGSNEKCQTF SDLAALGKSE
     ATKSPQYLSF FIRVFSGPYP MGTRATALNM ITSFLTSTEN TNLDFQALLP FLLVALTDAS
     ERVRREAAAA LAAVGSLYKK NKKGEDVWAR SNLYGQLKDI KWLPTRDAQK IFERAVLPSL
     EECIIDAAHI GRVLENTLRG VSVDANASEL KKPLRLAFFT FLCSNAIELP LFTPKLGLLN
     ILNRIDKAGG TTRTKELEPL LKTWRGFSER EVQDICEKER VPVSDVERQM VTIVTPKEKD
     AIMILLSNVS PHSESLRPSF IAAVFGRIKG IWARVAEDRQ VVAAEQLFEI SLGVSNLPLV
     NNCRDLLRSV QLPGSVLAQF LERIPVSLTD MEALGPAPKR RRTSQNNMIA MTVKDEAEFG
     KVMEKMTFIL ELVDSSSPET HPELADGLFQ ALAALHHFKS QIQSGMSYLL SLTLGSLLAI
     VNRSKESAKA QFDTSVIRAD LVVDCVRTTE SPQVQNAALL LVAGLSVIAP ELVLHSVMPI
     FTFMGSSVLR KDDEYSVSVI DQTIDQVVPA LIQSLRDQKR DVVSGTSELL LSFTAAFEHI
     PSHRRLRLFH ALITKLGTQD FLFAVLAMLA NRYAMDKDVL VLMTGLVSDA SAPVELTTYS
     KFLGLVSDSL KPKPGISQVL LGIGSDDGRE PQKVAVDLLR DLAYLFKHSS LKVKMAKTFA
     SEDEEAIRQL RTIFSQILEQ VLTIGDSVQS MKLVSQANGD VLAALFGTLT LVDFLDTIEV
     LLERPNDELR RKVLRLLEGR LRQNPERDSA SQIRVLDFLP TLVDIIRNSA DILLKHAAVA
     CIDRIAEKYG KKDPSRVVSA AQVVASEACI GQTDDRIRIM GVLCLASMAE TLGQVMIPAL
     PEALSRSLAL LELSLEEGKE NSRLHDAVFS LFSALFVHIP YMISGPHLDK ILLLSFKSAN
     AEDCEDDSRQ EALKMMARKV DMAATLGAVD RNWQYAVQAG PVATKETLEV VSLAVEKHPK
     SATGKNIGVL SSILFKAFDL RREQLALGAN ATFDAADVDE IEDALNDVTI KMIYKLNDTT
     FRPIFTKMLD WATSGLPKKD TQGSWARLTT FYKFLQVFFG TLQSIVTGYA SYIIESVVSV
     LGKASPADKS TKALWLATMR LLRNAFEHDQ DGMPVLPINP CLKLTITEFW QSPSHLNQIS
     TPLINQLAHA TNSSTAATVI AEAVPAITEL AVAADSTDNH KELNTALMKF LRPSAGPNGK
     PAGGENPHTR LAALKAEQSL TEQLGEEWLA LLPEMLPYIS ELMEDEDENV EREVRKWVKQ
     IENVLGEKLD DMLT