ID   UTP10_NEUCR             Reviewed;        1788 AA.
AC   Q7RZM8;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 10;
DE   AltName: Full=Ribosome biogenesis protein 5;
GN   Name=rbg-5; Synonyms=utp10; ORFNames=NCU00336;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1] {ECO:0000312|EMBL:EAA28571.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       Involved in ribosome biosynthesis (By similarity).
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:P42945}.
CC   -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
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DR   EMBL; CM002238; EAA28571.1; -; Genomic_DNA.
DR   RefSeq; XP_957807.1; XM_952714.2.
DR   AlphaFoldDB; Q7RZM8; -.
DR   SMR; Q7RZM8; -.
DR   STRING; 5141.EFNCRP00000000471; -.
DR   EnsemblFungi; EAA28571; EAA28571; NCU00336.
DR   GeneID; 3873977; -.
DR   KEGG; ncr:NCU00336; -.
DR   VEuPathDB; FungiDB:NCU00336; -.
DR   HOGENOM; CLU_001128_3_1_1; -.
DR   InParanoid; Q7RZM8; -.
DR   Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR   GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0034455; C:t-UTP complex; IBA:GO_Central.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012954; BP28_C_dom.
DR   InterPro; IPR022125; U3snoRNP10_N.
DR   InterPro; IPR040191; UTP10.
DR   PANTHER; PTHR13457; PTHR13457; 1.
DR   Pfam; PF08146; BP28CT; 1.
DR   Pfam; PF12397; U3snoRNP10; 1.
DR   SMART; SM01036; BP28CT; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..1788
FT                   /note="U3 small nucleolar RNA-associated protein 10"
FT                   /id="PRO_0000308509"
FT   REPEAT          585..622
FT                   /note="HEAT 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          926..962
FT                   /note="HEAT 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1049..1086
FT                   /note="HEAT 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1257..1294
FT                   /note="HEAT 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1301..1339
FT                   /note="HEAT 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1703..1740
FT                   /note="HEAT 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1744..1781
FT                   /note="HEAT 7"
FT                   /evidence="ECO:0000255"
FT   REGION          884..905
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1788 AA;  196892 MW;  C3CEB55A1C49459F CRC64;
     MSSLASQLAQ IAANSRSTLN TKVLKAAHSK SLIFEPRVAA TQTYPEIYSI CLEGFEELCN
     LDSRFTKFTQ SLWSPQSQEA DRTQMSAAEN AALDKHVEAF LHLCGSRLRL MPTIKAIEWL
     IRRFRVHEFN TAALIATFLP YHTIPAFVTL LSILPANIPK EYRFLDPYIR SLTAPPRAAI
     VQQATNRPEL LTAISQYTLD SCKYQMEYPG LISFWGGVMV EATNGLLDKY RSGRRSIQIE
     NDNALMQQLG PVLSDAMVMK SSPGLQIASY MVVTILAAKG GLADNALTAF MDQLVHGWTP
     ETMRPGLVTL CIISQHRSAK QLSARVTKAL LKVPEVASVM NEIGKDHRVD KLANGLALAL
     VDRLHKKGDV RSLPVVNSLL LGNVLREKQI KVVYKSLLVA AHRINDQVDQ DGAIRKELGT
     VLVSLSQAGG EVGDIVRATI DEVDFDIDAL ELTLGASIRP KLAVEDAPEA AAEDNNTPKV
     DKEAQVAQNF EKLSKLKPQT ASCFAEEPLD LLEELYSLFL SVAANESNLQ KFDEAPVLSR
     PQAPTKLFYA SFYMRLWCGS LPTLAKVAAL DRVKNLLKDE EFATLDFQAV VPYAIVALSD
     PAKKVRRAAA ELVTVLGSFY ETKPSKARRV WGSEGLYAKN AAVNWLDFDA TKSLIHSVLI
     PSLEESILHE DHILAALTNA LESSKSKDGD KKHLSHSTRF AIFKFLSSHV VGTPLIAVKL
     RLLQSLNQIK SISGTSRTDL LLSLLQWWAR LSEAEAQQLL AREAVDEASV NNAFVDVVIA
     NNEAGLRLIF ELIRDSNVIT RNGLVQSLFS RVQKIWSSMK AETQFSTARA LLTLSQAVHP
     TSSEPDVIAT EATDVLHKVE LTTDILLDFL ESLYDDIKKA TEKPATKRRR VGSSEKSVDS
     QSPADVSASL SKATFVLELV QESEPAKHPE LLPSLFTTLS ELQHLRTVVG SELGYLQSLV
     LSSLLAMMPA YKDSKELTID PAAGHGDILA SCIQRSSSPT VINAALLLVA SLARTAPDVV
     LHSVMPIFTF MGSSVLKQAD DYSAHVVNQT VKEVIPPLIE TFRKSRRNLV ASTAELLTSF
     VVAYEHIPSH RKQDLFITLI ENLGPEDFLF AVLAMFVDKY GATDNMLAFT TQIIGSFSVE
     IQLQTLIKHL DLISDIFKPK PVLSAALLAK VDSNSEQDVV KLATKQLTLL PKLLVNRRLR
     HEISGLAEKD DMESVKIREL YAQLLEGVLT LAGTVKPKKD TLYTRCAEAL SNLLNLLSIA
     EFIKSVEALL DRPNVILRQK VLRALERRVD SESINNPKSR EALLAFLPQL TAVIRESDDM
     NYKHTAVNCV DKIAEKYGKK DLDAVAAAAA TIAGDSCLGQ PSQELRVMAL LCLASLVDVL
     QDAIVPVLPI AIPKALGCLE ESIKAEKPDG ALHNAAYAFM AALAQHIPYM ISGAYLDRLL
     VCSNASAAAG LNEECRDSRT DCLQFVAKLI EGKVLFTALE KNWANAASSG YLALEEYLHV
     LGTALDKHPK SSIAKNTTLF TGIFLNAFDL RRSGVLSSTQ ELEKIELLIN ETSLKMIYKL
     NDAAFRPMFS HLMEWSTTGL PKSDLAGKAQ RQVSTYGFLQ HFFENLKSIV TSYASYIIDS
     AVKILSAPLT SDDVLKTLRS RVLRTLTKCF EHDQDGFWQA PAHFNAVAPV LVAQFGHAAG
     ADNCTNDLVL AVVELAAAAD SKEHHKEINS ALLKHLRSEQ AAVRLAVIKC EQELTARLGE
     EWLQSLPEML PFISELQDDD DEVVERENRR WIVGIEETLG ESLDNMLQ