UTP10_PICST
ID UTP10_PICST Reviewed; 1836 AA.
AC A3GGS6;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JAN-2010, sequence version 2.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=U3 small nucleolar RNA-associated protein 10;
GN Name=UTP10 {ECO:0000250|UniProtKB:P42945}; ORFNames=PICST_85815;
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC Involved in ribosome biosynthesis (By similarity).
CC {ECO:0000250|UniProtKB:P42945}.
CC -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC {ECO:0000250|UniProtKB:P42945}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:P42945,
CC ECO:0000255}. Membrane {ECO:0000255}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
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DR EMBL; AAVQ01000001; EAZ63583.2; -; Genomic_DNA.
DR RefSeq; XP_001387606.2; XM_001387569.1.
DR AlphaFoldDB; A3GGS6; -.
DR SMR; A3GGS6; -.
DR STRING; 4924.XP_001387606.2; -.
DR PRIDE; A3GGS6; -.
DR EnsemblFungi; EAZ63583; EAZ63583; PICST_85815.
DR GeneID; 4851475; -.
DR KEGG; pic:PICST_85815; -.
DR eggNOG; KOG1837; Eukaryota.
DR HOGENOM; CLU_001128_3_1_1; -.
DR InParanoid; A3GGS6; -.
DR OMA; YTNQLLF; -.
DR OrthoDB; 524830at2759; -.
DR Proteomes; UP000002258; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012954; BP28_C_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR022125; U3snoRNP10_N.
DR InterPro; IPR040191; UTP10.
DR PANTHER; PTHR13457; PTHR13457; 1.
DR Pfam; PF08146; BP28CT; 1.
DR Pfam; PF12397; U3snoRNP10; 1.
DR SMART; SM01036; BP28CT; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 3: Inferred from homology;
KW Membrane; Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; rRNA processing; Transmembrane; Transmembrane helix.
FT CHAIN 1..1836
FT /note="U3 small nucleolar RNA-associated protein 10"
FT /id="PRO_0000308512"
FT TRANSMEM 998..1018
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1085..1105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 245..283
FT /note="HEAT 1"
FT /evidence="ECO:0000255"
FT REPEAT 585..623
FT /note="HEAT 2"
FT /evidence="ECO:0000255"
FT REPEAT 813..850
FT /note="HEAT 3"
FT /evidence="ECO:0000255"
FT REPEAT 1333..1372
FT /note="HEAT 4"
FT /evidence="ECO:0000255"
FT REPEAT 1749..1787
FT /note="HEAT 5"
FT /evidence="ECO:0000255"
FT REPEAT 1790..1828
FT /note="HEAT 6"
FT /evidence="ECO:0000255"
FT REGION 453..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 863..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1836 AA; 207113 MW; 82CB09C498C353A8 CRC64;
MSSLADQLKV IKEKTASVVL DRKARSKIHS RSLIFDPKVA STQDYDYLYQ LGLEGLDELS
EIDSRFSKFR HTLFSETSVS MDRNVQTKDV ISQLDKNIDA FLTLAGPFYS LAPTVKAVEW
LVRRFHINMH NGEMLLLTSL PHYNQSVFVK ILNVIPKNSF PKIFDWVVGY KDLLKNPPSS
SILKAFHNDF EFFKLYAMFL VEQLKNGTVY QEQLSFFLST TVQLLASLSK SLDTLNENHL
PVVLEVVGFL LLPSKYETLR NIDVDTRLTA YSIIAVLASI IPISTELIRS FTESILQDPR
SLEPNSVRQT LIVLSQLWRF YQGDFSDREA IVKCFANLAP SKLIKVEHLV KDLVADNYKF
QKFLTFYFFA TFPNPESYKI FQLVDLGKSE LYFSEIAKQI VENSTATDKC RSVVIHICEE
LLKSNSELFI KALATQEMNI DALEMKLMTT LGSNSSVRDS DDVEFDAGEE DNNDEETEEV
AVQFATAANL DSIKSSSKSF FTSSSDSEFS KLTLDLISLL RNVTVKVQKS LLLKFTTSVF
SSIETGISFL IRIAFTPSIP LSIRLTAIRC TKWKLKEAST SSSSPLDLYL LIPIFLLGVY
DETRVVRAGF VQLLRFIKET TTSIHANKKK VKSVLFMEDV IYDTTEASKR AIISPNDALF
FTELLLKEDV LEDVIIDRSR LVPKFGQLIL KTFVINQWSL NFFPVVFKWR AWNIVALENK
NGTEDRFFFT DSDLSEYFTK RSNWIQQAND AKIAFFEEVE GAIVGLVGGN STNEAKTATE
VDWIIQSLNS QFSNLQIAVN SRLLEIFNNF STVENRIKIV NKLIDLLNND EPIESDPMDT
LQTLKLDQDL FISVLGNVQI GGQIPEQGPA KRRRRSSSST KQAMAREDIN NMASTHLKKL
TIILDLLETN LRNGTETIAS PNLLQALFKI LTDLDYLGND GNLPVLYAQE ALASCMILSI
VKMKNSDETF KFDSNSIRAD LIVNSIRSSQ SPQVQNRLLL VIAELASLAP EIVLHSVMPI
FTFMGAHTVR QDDEFSSSAL QQTIAKVIPA VAANGSSSIS NEIEFLLTSF VTAFQHIPRH
RRVKLFTYLI RTLGSDLSLH VLLFLMGQQY CSSLNKNKMA DAQVILEFTS SFLKSFSAIE
QLEGISKFAE LWDMIPIAEL EANSEEYNKL STRSIFGVSI LSLTNSGLST LRIEMLKYIS
SVVATENSNF DANTLKTKVA MVLLDSSIND DDEEKKSILG SFRNVAAFLL SSLDTFTNVS
RNSEIALSLY DLLANFLNLL PIHYFVDSIF ESLDVGKFSD TLSIKVAKNL VILAGAKFES
ELSSINIDEK IEESVLEKLL PVLLHGIKKN VDIELEQAYL DTFAIIVNKF GASTKTLATP
TNSRLLLESL QAITSENCLL SESPETIISS INAITSIVNV LGVKTIGIFP KIVPPSLKIW
ETTTHSEDEE SAKLIQSSII VLLSCLIKKI PAFMTSSLDS IFITILSSDY VDNSIRTSVL
GLVVEHMDSS QVLKSLCNIW CNKKFYENDN TGNIGLYLNT MQSTIDKIDK KSAATQSTVF
IKWLIQAFEF RHYSEEADNK FDNNTIHRLE SSFHSCGISY VMKLNDKKFR PLFATLVRWA
VEGEGSNFSE NTEVSRLVAF FKFFNKMQEQ LKSIITSYFS YLLDPVASVL TRFSSGQLKD
INLRRILLNS LTSSFKYDQD DYWSQQGRFD SICNPLLEQL TNIEEGIGKY LIKSITAFIN
NVASEEYNET LVHGLIKYIS NEKEDNSSST KIWTIRALKS IFQKMGEQWL TYLPTLIPYI
AELLEDDDQA VEMEVRSGLV RVIENVLGEP LDRYLD
