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UTP10_SCHPO
ID   UTP10_SCHPO             Reviewed;        1649 AA.
AC   O60179;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 10;
DE            Short=U3 snoRNA-associated protein 10;
DE   AltName: Full=U3 protein 10 required for transcription;
GN   Name=utp10; ORFNames=SPBC23E6.04c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       Required for optimal pre-ribosomal RNA transcription by RNA polymerase
CC       I together with a subset of U3 proteins required for transcription (t-
CC       UTPs). Involved in ribosome biosynthesis (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA18872.1; -; Genomic_DNA.
DR   PIR; T39938; T39938.
DR   RefSeq; NP_596604.1; NM_001022525.2.
DR   AlphaFoldDB; O60179; -.
DR   SMR; O60179; -.
DR   BioGRID; 276815; 5.
DR   STRING; 4896.SPBC23E6.04c.1; -.
DR   iPTMnet; O60179; -.
DR   MaxQB; O60179; -.
DR   PaxDb; O60179; -.
DR   PRIDE; O60179; -.
DR   EnsemblFungi; SPBC23E6.04c.1; SPBC23E6.04c.1:pep; SPBC23E6.04c.
DR   GeneID; 2540284; -.
DR   KEGG; spo:SPBC23E6.04c; -.
DR   PomBase; SPBC23E6.04c; utp10.
DR   VEuPathDB; FungiDB:SPBC23E6.04c; -.
DR   eggNOG; KOG1837; Eukaryota.
DR   HOGENOM; CLU_001128_3_1_1; -.
DR   InParanoid; O60179; -.
DR   OMA; YTNQLLF; -.
DR   PhylomeDB; O60179; -.
DR   Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:O60179; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR   GO; GO:0030688; C:preribosome, small subunit precursor; ISO:PomBase.
DR   GO; GO:0032040; C:small-subunit processome; ISO:PomBase.
DR   GO; GO:0034455; C:t-UTP complex; ISO:PomBase.
DR   GO; GO:0030515; F:snoRNA binding; ISO:PomBase.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012954; BP28_C_dom.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR022125; U3snoRNP10_N.
DR   InterPro; IPR040191; UTP10.
DR   PANTHER; PTHR13457; PTHR13457; 1.
DR   Pfam; PF08146; BP28CT; 1.
DR   Pfam; PF12397; U3snoRNP10; 1.
DR   SMART; SM01036; BP28CT; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing; Transcription.
FT   CHAIN           1..1649
FT                   /note="U3 small nucleolar RNA-associated protein 10"
FT                   /id="PRO_0000186206"
FT   REPEAT          1608..1646
FT                   /note="HEAT"
SQ   SEQUENCE   1649 AA;  186412 MW;  6B4FD373125216D9 CRC64;
     MASSLQKQLK NIQSNNVLKI NKIRRAPSLL YDPKVAADMD LEEIYVTAVS GFHELAVHEP
     RLLYFEKTLL GEQSVQVDRV LLNRTENEKI DLECVQILRL LAPFFTEKNA LKVLEWLIRR
     FSIHEYVSDE FILSFLPFHD HPFFARILGC SKPKSRPLLF LENAIKMPVT LSRADIVHAL
     SRDKEFFAMF AQFVQNTAES HNMYPELARF WAGTMMEVLV AWHSSNEDPN VLLDRFFLRV
     SYAVSYVSSI DFQIAGFMLL SSIAASLPLS PSIIPPLVSA ITDRLSFDNI KPALICVGHL
     LQFCSSFEFD HEQLEKLESF GASSLLIELS QEHRLDEFFV SYWVSLIKSR KQKDKKRLIS
     LLDTSISQIR VTHEQAKFLL SVIPVNQDFK ALQSYRRILD SVIQPERKEG KLDNLINTLQ
     DKKKSSTFSK KDREVLLKKI SEIDSQTSFE QCLAYADSAA DLDSSVFISL LSKFGDKIPF
     LLFCIANGSE RIIILSLIEL RKTIEENKDV DYQIILPVVL YSLQSKDTEV RSRALNLILT
     FLELRNENLE FSIIYGMDDN DNKNLRWLSP VETKYYCSDL LLDRSSEIGL DGTYLFSYIP
     ERLFTEKKPK NASKEIAVTS FLSSHAACSK LSNVRVLLLE ILTRVHGKVE DAKMQILLPR
     LEQLSEFNSE KFKTVSKREV EALVNCFNHT SFTSLLSFLS SNIVLSQAIC RRIVEIQSHL
     KDPQRLEFVK AVISQDEQPH YYVDVLDSIK IPDTVFKKLI GSVRLVKEKN PAIAKRKRID
     SHIFDGDVQR LTRILELLET KNAASYPKLA SPLFEVLNSV IALKEDIVSS NYLLQLLLGL
     LYEMIGASPI TELSPSIRID TLVGCIRSTN NPQIQNKALL LVSALANAAP EAVLHGVMPI
     FTFMGSTVLS RDDAFSIHVI EQTVKTVISA LIRLGKDFDS SLLVSCFVNA FPHIPQHRRL
     RLYRLVLQTI GSNRFLSVVL IQFAEKMLLA KSTNVVAIHD FCLTLVQSFS VADRIGSINQ
     CSRFCLKSLE EQSNSDSNGK AVSLIKLDEL PMDVDLATLG SLRVKVLELI SLVSKAKNFA
     FDLAKIMENS VDSFVEIQAG LFESIKLLIT LSQQSSNEME LGHVYVALRS VIHLLPNELF
     CTVLGKLLHD ERALLRRKAL SIVQQRVQQG SKVSALTALI PDVTYNISNY SDEETTQLAM
     DCLAVMAKRF SASPELFISP IEVVSGPYGL KNSARDVQVS AIVCITVLTN TLAARILPYL
     ADIVNYSLSI LDDARKDPEG DLLELACFSM MIDFFKVLPE FSSSYVEPTI KCALASDRAF
     EHDAIGELLF ETIANFIPTR LLMKSIFAAW PECARLGSTA ALRLLELIEL ALQNSSRSAI
     GTVYKSIFKF FLDSFDSRRS LLFAEDVDNV ETQAVNVFLK FVMKLSDTTF RPLFLHLHSW
     ALEDLYETDP SGIVSRQTFF YNFLTIFLDT LKSIVTNYYA YVLDDTIELL SSKDTNSEVR
     HLVNSSLVSA FENDTEEFWM VPARFGKISP VLIEQIQYAP LLDDKVLVKA IVELASVASS
     SDNFRSMNTQ LLQYLRSSNI NARLLAIQIQ TQLYGRLGEN WISTLPQSVP FIAELMEDDD
     DQVETATAEL VRIIDDRLGE NESLQDYLT
 
 
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