UTP10_SCHPO
ID UTP10_SCHPO Reviewed; 1649 AA.
AC O60179;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=U3 small nucleolar RNA-associated protein 10;
DE Short=U3 snoRNA-associated protein 10;
DE AltName: Full=U3 protein 10 required for transcription;
GN Name=utp10; ORFNames=SPBC23E6.04c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC Required for optimal pre-ribosomal RNA transcription by RNA polymerase
CC I together with a subset of U3 proteins required for transcription (t-
CC UTPs). Involved in ribosome biosynthesis (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA18872.1; -; Genomic_DNA.
DR PIR; T39938; T39938.
DR RefSeq; NP_596604.1; NM_001022525.2.
DR AlphaFoldDB; O60179; -.
DR SMR; O60179; -.
DR BioGRID; 276815; 5.
DR STRING; 4896.SPBC23E6.04c.1; -.
DR iPTMnet; O60179; -.
DR MaxQB; O60179; -.
DR PaxDb; O60179; -.
DR PRIDE; O60179; -.
DR EnsemblFungi; SPBC23E6.04c.1; SPBC23E6.04c.1:pep; SPBC23E6.04c.
DR GeneID; 2540284; -.
DR KEGG; spo:SPBC23E6.04c; -.
DR PomBase; SPBC23E6.04c; utp10.
DR VEuPathDB; FungiDB:SPBC23E6.04c; -.
DR eggNOG; KOG1837; Eukaryota.
DR HOGENOM; CLU_001128_3_1_1; -.
DR InParanoid; O60179; -.
DR OMA; YTNQLLF; -.
DR PhylomeDB; O60179; -.
DR Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:O60179; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR GO; GO:0030688; C:preribosome, small subunit precursor; ISO:PomBase.
DR GO; GO:0032040; C:small-subunit processome; ISO:PomBase.
DR GO; GO:0034455; C:t-UTP complex; ISO:PomBase.
DR GO; GO:0030515; F:snoRNA binding; ISO:PomBase.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012954; BP28_C_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR022125; U3snoRNP10_N.
DR InterPro; IPR040191; UTP10.
DR PANTHER; PTHR13457; PTHR13457; 1.
DR Pfam; PF08146; BP28CT; 1.
DR Pfam; PF12397; U3snoRNP10; 1.
DR SMART; SM01036; BP28CT; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW rRNA processing; Transcription.
FT CHAIN 1..1649
FT /note="U3 small nucleolar RNA-associated protein 10"
FT /id="PRO_0000186206"
FT REPEAT 1608..1646
FT /note="HEAT"
SQ SEQUENCE 1649 AA; 186412 MW; 6B4FD373125216D9 CRC64;
MASSLQKQLK NIQSNNVLKI NKIRRAPSLL YDPKVAADMD LEEIYVTAVS GFHELAVHEP
RLLYFEKTLL GEQSVQVDRV LLNRTENEKI DLECVQILRL LAPFFTEKNA LKVLEWLIRR
FSIHEYVSDE FILSFLPFHD HPFFARILGC SKPKSRPLLF LENAIKMPVT LSRADIVHAL
SRDKEFFAMF AQFVQNTAES HNMYPELARF WAGTMMEVLV AWHSSNEDPN VLLDRFFLRV
SYAVSYVSSI DFQIAGFMLL SSIAASLPLS PSIIPPLVSA ITDRLSFDNI KPALICVGHL
LQFCSSFEFD HEQLEKLESF GASSLLIELS QEHRLDEFFV SYWVSLIKSR KQKDKKRLIS
LLDTSISQIR VTHEQAKFLL SVIPVNQDFK ALQSYRRILD SVIQPERKEG KLDNLINTLQ
DKKKSSTFSK KDREVLLKKI SEIDSQTSFE QCLAYADSAA DLDSSVFISL LSKFGDKIPF
LLFCIANGSE RIIILSLIEL RKTIEENKDV DYQIILPVVL YSLQSKDTEV RSRALNLILT
FLELRNENLE FSIIYGMDDN DNKNLRWLSP VETKYYCSDL LLDRSSEIGL DGTYLFSYIP
ERLFTEKKPK NASKEIAVTS FLSSHAACSK LSNVRVLLLE ILTRVHGKVE DAKMQILLPR
LEQLSEFNSE KFKTVSKREV EALVNCFNHT SFTSLLSFLS SNIVLSQAIC RRIVEIQSHL
KDPQRLEFVK AVISQDEQPH YYVDVLDSIK IPDTVFKKLI GSVRLVKEKN PAIAKRKRID
SHIFDGDVQR LTRILELLET KNAASYPKLA SPLFEVLNSV IALKEDIVSS NYLLQLLLGL
LYEMIGASPI TELSPSIRID TLVGCIRSTN NPQIQNKALL LVSALANAAP EAVLHGVMPI
FTFMGSTVLS RDDAFSIHVI EQTVKTVISA LIRLGKDFDS SLLVSCFVNA FPHIPQHRRL
RLYRLVLQTI GSNRFLSVVL IQFAEKMLLA KSTNVVAIHD FCLTLVQSFS VADRIGSINQ
CSRFCLKSLE EQSNSDSNGK AVSLIKLDEL PMDVDLATLG SLRVKVLELI SLVSKAKNFA
FDLAKIMENS VDSFVEIQAG LFESIKLLIT LSQQSSNEME LGHVYVALRS VIHLLPNELF
CTVLGKLLHD ERALLRRKAL SIVQQRVQQG SKVSALTALI PDVTYNISNY SDEETTQLAM
DCLAVMAKRF SASPELFISP IEVVSGPYGL KNSARDVQVS AIVCITVLTN TLAARILPYL
ADIVNYSLSI LDDARKDPEG DLLELACFSM MIDFFKVLPE FSSSYVEPTI KCALASDRAF
EHDAIGELLF ETIANFIPTR LLMKSIFAAW PECARLGSTA ALRLLELIEL ALQNSSRSAI
GTVYKSIFKF FLDSFDSRRS LLFAEDVDNV ETQAVNVFLK FVMKLSDTTF RPLFLHLHSW
ALEDLYETDP SGIVSRQTFF YNFLTIFLDT LKSIVTNYYA YVLDDTIELL SSKDTNSEVR
HLVNSSLVSA FENDTEEFWM VPARFGKISP VLIEQIQYAP LLDDKVLVKA IVELASVASS
SDNFRSMNTQ LLQYLRSSNI NARLLAIQIQ TQLYGRLGEN WISTLPQSVP FIAELMEDDD
DQVETATAEL VRIIDDRLGE NESLQDYLT