ID   UTP11_LEIMA             Reviewed;         361 AA.
AC   Q9U178; Q4QDF4;
DT   04-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Probable U3 small nucleolar RNA-associated protein 11;
DE            Short=U3 snoRNA-associated protein 11;
GN   ORFNames=L374.02, LmjF19.0670, LmjF_19_0670;
OS   Leishmania major.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/IL/81/Friedlin;
RX   PubMed=16020728; DOI=10.1126/science.1112680;
RA   Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA   Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA   Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA   Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA   Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M.,
RA   De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA   Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA   Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA   Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA   Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S.,
RA   Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA   Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA   Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA   Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K.,
RA   Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA   Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA   Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA   Barrell B.G., Myler P.J.;
RT   "The genome of the kinetoplastid parasite, Leishmania major.";
RL   Science 309:436-442(2005).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP11 family. {ECO:0000305}.
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DR   EMBL; FR796415; CAJ07152.1; -; Genomic_DNA.
DR   RefSeq; XP_001682644.1; XM_001682592.1.
DR   AlphaFoldDB; Q9U178; -.
DR   STRING; 5664.LmjF.19.0670; -.
DR   PRIDE; Q9U178; -.
DR   EnsemblProtists; CAJ07152; CAJ07152; LMJF_19_0670.
DR   GeneID; 5651166; -.
DR   KEGG; lma:LMJF_19_0670; -.
DR   VEuPathDB; TriTrypDB:LmjF.19.0670; -.
DR   VEuPathDB; TriTrypDB:LMJLV39_190012300; -.
DR   VEuPathDB; TriTrypDB:LMJSD75_190011900; -.
DR   eggNOG; KOG3237; Eukaryota.
DR   InParanoid; Q9U178; -.
DR   OMA; MTKGKGR; -.
DR   Proteomes; UP000000542; Chromosome 19.
DR   GO; GO:0005730; C:nucleolus; ISO:GeneDB.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR007144; SSU_processome_Utp11.
DR   PANTHER; PTHR12838; PTHR12838; 1.
DR   Pfam; PF03998; Utp11; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; rRNA processing.
FT   CHAIN           1..361
FT                   /note="Probable U3 small nucleolar RNA-associated protein
FT                   11"
FT                   /id="PRO_0000211047"
FT   REGION          1..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          200..235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          262..295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          311..361
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        209..230
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..337
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        338..361
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   361 AA;  41779 MW;  F033DC1CC6485A97 CRC64;
     MTKGKGRNPG ASGLDKHLKR KTHLERSQPK SRQHLGQLEK HKDHVLRAKK RKVKVRRLQE
     IKRAAAQRNP DEFNIGMTKA VMDVANGRMR QRRVRLVESD RKKDMQTTIE HNRRNVQYLE
     FKAQADQQRA TELLNEEAAA ALTSTAPQNK HIVFVNSEEE FRSFNPLKHF DVTPEMMRQH
     PAVRGRIRVL EKTVMPEEIL MSGGHQIKSA AQKRKERREV QEKMRRSGAD ATPETRAAFV
     ERLRAKKELK QYQFTDLLEE VKRESEATAS SSKGAPGDDG EQEEAAAQDE VTRLLEWRRE
     QERQAAIATA RHVREVGQRI QRSKSLSALA KSIRKQSQGI KRQMEQRRES RFKPGATRRA
     R