UTP11_MOUSE
ID UTP11_MOUSE Reviewed; 253 AA.
AC Q9CZJ1; Q3UI21; Q9CVB5;
DT 04-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Probable U3 small nucleolar RNA-associated protein 11;
DE Short=U3 snoRNA-associated protein 11;
DE AltName: Full=UTP11-like protein;
GN Name=Utp11; Synonyms=Utp11l {ECO:0000312|MGI:MGI:1914455};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Amnion, Embryo, Mammary gland, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the UTP11 family. {ECO:0000305}.
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DR EMBL; AK008801; BAB25903.1; -; mRNA.
DR EMBL; AK012550; BAB28310.1; -; mRNA.
DR EMBL; AK145266; BAE26334.1; -; mRNA.
DR EMBL; AK147113; BAE27685.1; -; mRNA.
DR EMBL; BC061074; AAH61074.1; -; mRNA.
DR CCDS; CCDS18623.1; -.
DR RefSeq; NP_080307.1; NM_026031.3.
DR AlphaFoldDB; Q9CZJ1; -.
DR SMR; Q9CZJ1; -.
DR BioGRID; 212015; 42.
DR STRING; 10090.ENSMUSP00000030738; -.
DR iPTMnet; Q9CZJ1; -.
DR PhosphoSitePlus; Q9CZJ1; -.
DR EPD; Q9CZJ1; -.
DR jPOST; Q9CZJ1; -.
DR MaxQB; Q9CZJ1; -.
DR PaxDb; Q9CZJ1; -.
DR PeptideAtlas; Q9CZJ1; -.
DR PRIDE; Q9CZJ1; -.
DR ProteomicsDB; 300204; -.
DR Antibodypedia; 31826; 132 antibodies from 18 providers.
DR DNASU; 67205; -.
DR Ensembl; ENSMUST00000030738; ENSMUSP00000030738; ENSMUSG00000028907.
DR GeneID; 67205; -.
DR KEGG; mmu:67205; -.
DR UCSC; uc008uqu.1; mouse.
DR CTD; 51118; -.
DR MGI; MGI:1914455; Utp11.
DR VEuPathDB; HostDB:ENSMUSG00000028907; -.
DR eggNOG; KOG3237; Eukaryota.
DR GeneTree; ENSGT00390000005813; -.
DR HOGENOM; CLU_061887_2_1_1; -.
DR InParanoid; Q9CZJ1; -.
DR OMA; YVVMKRT; -.
DR OrthoDB; 1346432at2759; -.
DR PhylomeDB; Q9CZJ1; -.
DR TreeFam; TF314171; -.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 67205; 27 hits in 75 CRISPR screens.
DR ChiTaRS; Utp11; mouse.
DR PRO; PR:Q9CZJ1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9CZJ1; protein.
DR Bgee; ENSMUSG00000028907; Expressed in floor plate of midbrain and 247 other tissues.
DR Genevisible; Q9CZJ1; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:HGNC.
DR GO; GO:0005615; C:extracellular space; ISS:HGNC.
DR GO; GO:0005730; C:nucleolus; ISS:HGNC.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; ISS:HGNC-UCL.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISS:HGNC.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR007144; SSU_processome_Utp11.
DR PANTHER; PTHR12838; PTHR12838; 1.
DR Pfam; PF03998; Utp11; 1.
DR PIRSF; PIRSF015952; U3snoRNP11; 1.
PE 2: Evidence at transcript level;
KW Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome;
KW rRNA processing; Ubl conjugation.
FT CHAIN 1..253
FT /note="Probable U3 small nucleolar RNA-associated protein
FT 11"
FT /id="PRO_0000211043"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 90
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT MOD_RES 241
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 74
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 83
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 86
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 103
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 120
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 143
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 144
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 180
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 218
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 235
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 236
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
SQ SEQUENCE 253 AA; 30551 MW; 469CD89D485BAF9F CRC64;
MSAAFRKAAK TRQREHRERS QPGFRKRLGL LEKKKDYKLR ANDYHKKQDF LRALRKKALE
KNPDEFYYKM TRAKLQDGVH IFKENKEEVT AEQLKLMRTQ DIKYIEMKRV AEAKKIERLK
SELHLLDFQG KQQKKHVFFF DTKKEVERFD VATHLQTAPE LVDRVYNRPR IETLQKERVK
GATPQTGLKR IAKERQKQYD CLTQRIEREK QLFVVAQKIQ TRKDLMDKTQ KVKVKKETVN
SPAIYRFQTR RKR
