UTP11_RAT
ID UTP11_RAT Reviewed; 253 AA.
AC Q8R5K5;
DT 04-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Probable U3 small nucleolar RNA-associated protein 11;
DE Short=U3 snoRNA-associated protein 11;
DE AltName: Full=UTP11-like protein;
GN Name=Utp11 {ECO:0000312|RGD:621412};
GN Synonyms=Utp11l {ECO:0000312|RGD:621412};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=11860508; DOI=10.1046/j.0953-816x.2001.01836.x;
RA Heese K., Nakayama T., Hata R., Masumura M., Akatsu H., Li F., Nagai Y.,
RA Yamamoto T., Kosaka K., Suemoto T., Sawada T.;
RT "Characterizing CGI-94 (comparative gene identification-94) which is down-
RT regulated in the hippocampus of early stage Alzheimer's disease brain.";
RL Eur. J. Neurosci. 15:79-86(2002).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11860508}.
CC -!- SIMILARITY: Belongs to the UTP11 family. {ECO:0000305}.
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DR EMBL; AF350421; AAL74316.1; -; mRNA.
DR AlphaFoldDB; Q8R5K5; -.
DR SMR; Q8R5K5; -.
DR RGD; 621412; Utp11.
DR InParanoid; Q8R5K5; -.
DR PhylomeDB; Q8R5K5; -.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:Q8R5K5; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0005730; C:nucleolus; ISO:RGD.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; ISO:RGD.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:RGD.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR007144; SSU_processome_Utp11.
DR PANTHER; PTHR12838; PTHR12838; 1.
DR Pfam; PF03998; Utp11; 1.
DR PIRSF; PIRSF015952; U3snoRNP11; 1.
PE 2: Evidence at transcript level;
KW Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome;
KW rRNA processing; Ubl conjugation.
FT CHAIN 1..253
FT /note="Probable U3 small nucleolar RNA-associated protein
FT 11"
FT /id="PRO_0000211044"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 90
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT MOD_RES 241
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 74
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 83
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 86
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 103
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 120
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 143
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 144
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 180
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 211
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 218
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 235
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 236
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
FT CROSSLNK 246
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3A2"
SQ SEQUENCE 253 AA; 30499 MW; 3CAFD1AE30996D4B CRC64;
MAAAFRKAVK SRQREYRERS QPGFRKHLGL LEKKKDYKLR ADDYRKKQEY LKALRKKALE
KNPDEFYYKM TRVKLQDGVH IIKETKEEVT PEQLKLMRTQ DVKYIEMKRV AEAKKIERLK
SELHLLDFQG KQQNRHVFFF DTKKEVEQFD VAAHLQTAPE LVDRVFNRPR IETLQKEKVK
GVTNQTGLKR IAKERQKQYN CLTQRIEREK KLFVIAQKIQ TRKDLMDKTQ KVKVKKETVN
SPAIYKFQSR RKR
