ID   UTP15_BOVIN             Reviewed;         519 AA.
AC   A7MB12;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 15 homolog;
GN   Name=UTP15 {ECO:0000250|UniProtKB:Q8TED0};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000312|EMBL:AAI51280.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford {ECO:0000312|EMBL:AAI51280.1};
RC   TISSUE=Thymus {ECO:0000312|EMBL:AAI51280.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Ribosome biogenesis factor. Involved in nucleolar processing
CC       of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA
CC       transcription by RNA polymerase I. {ECO:0000250|UniProtKB:Q8TED0}.
CC   -!- SUBUNIT: Interacts directly with UTP4 and WDR43 (). May be a component
CC       of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU)
CC       processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75.
CC       {ECO:0000250|UniProtKB:Q8TED0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q8TED0}. Note=Found predominantly at the
CC       fibrillar center. {ECO:0000250|UniProtKB:Q8TED0}.
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DR   EMBL; BC151279; AAI51280.1; -; mRNA.
DR   RefSeq; NP_001094598.1; NM_001101128.2.
DR   AlphaFoldDB; A7MB12; -.
DR   SMR; A7MB12; -.
DR   STRING; 9913.ENSBTAP00000036690; -.
DR   PaxDb; A7MB12; -.
DR   PRIDE; A7MB12; -.
DR   Ensembl; ENSBTAT00000036838; ENSBTAP00000036690; ENSBTAG00000006843.
DR   GeneID; 526343; -.
DR   KEGG; bta:526343; -.
DR   CTD; 84135; -.
DR   VEuPathDB; HostDB:ENSBTAG00000006843; -.
DR   VGNC; VGNC:36742; UTP15.
DR   eggNOG; KOG0267; Eukaryota.
DR   eggNOG; KOG0310; Eukaryota.
DR   GeneTree; ENSGT00390000004228; -.
DR   HOGENOM; CLU_021102_4_1_1; -.
DR   InParanoid; A7MB12; -.
DR   OMA; WKEHKQP; -.
DR   OrthoDB; 621827at2759; -.
DR   TreeFam; TF319494; -.
DR   Proteomes; UP000009136; Chromosome 20.
DR   Bgee; ENSBTAG00000006843; Expressed in conceptus and 105 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001650; C:fibrillar center; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:2000234; P:positive regulation of rRNA processing; IEA:Ensembl.
DR   GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR018983; U3_snoRNA-assocProt_15_C.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF09384; UTP15_C; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Isopeptide bond; Nucleus; Reference proteome; Repeat;
KW   Ribosome biogenesis; rRNA processing; Transcription;
KW   Transcription regulation; Ubl conjugation; WD repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TED0"
FT   CHAIN           2..519
FT                   /note="U3 small nucleolar RNA-associated protein 15
FT                   homolog"
FT                   /id="PRO_0000314595"
FT   REPEAT          36..75
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          78..117
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          120..159
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          162..202
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          204..242
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          246..285
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          287..326
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TED0"
FT   CROSSLNK        249
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TED0"
SQ   SEQUENCE   519 AA;  58495 MW;  326D93DEB6CEEED9 CRC64;
     MAGYKPVSIQ TYPVLGEKIT QDTLYWNNYK TPVQIKEFGA VSKVDFSPQP PYNYAVTASS
     RIHIYGRYSQ EPIKTFSRFK DTAYCATFRQ DGRLLVAGSE DGGVQLFDIS GRAPLRQFEG
     HTKAVHSVDF TADKYHVVSG ADDYTVKLWD IPNSKEILTF KEHSDYVRCG CASKLNTDLF
     VTGSYDHTVK MFDARTNQSV ISVEHGQPVE SVLLFPSGGL LVSAGGRYVK VWDMLKGGQL
     LVSLKNHHKT VTCLCLSSSG QRLLSGSLDR KVKVYSTTSY KVVHSFDYTA SILSLALAHE
     DETIVVGMTN GILSVKHRKS EAKKDSVPRR RRPAYRTFIK GKNYMKQQDD ILINRPSKKH
     LELYDRDLKN FRISKALDRV LEPTCTIKTP EVTVSIIKEL NRRGVLANAL AGRDEKEISR
     VLNFLIRNLS QPRFAPVLIN AAEIIIDIYL PVIGQSPVVD KKFLILQGLV EKEIDYQREL
     LETLGMMDML FATMTRKEST SVLQHNTSDG FLENNKIES