ID   UTP15_DANRE             Reviewed;         517 AA.
AC   Q7ZW33; Q6TGY5;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 15 homolog;
GN   Name=utp15;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
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DR   EMBL; AY398371; AAQ97804.1; -; mRNA.
DR   EMBL; BC045308; AAH45308.1; -; mRNA.
DR   RefSeq; NP_955998.1; NM_199704.1.
DR   RefSeq; XP_005159039.1; XM_005158982.3.
DR   AlphaFoldDB; Q7ZW33; -.
DR   SMR; Q7ZW33; -.
DR   STRING; 7955.ENSDARP00000106434; -.
DR   PaxDb; Q7ZW33; -.
DR   Ensembl; ENSDART00000127397; ENSDARP00000106434; ENSDARG00000002720.
DR   Ensembl; ENSDART00000148774; ENSDARP00000124648; ENSDARG00000002720.
DR   GeneID; 325106; -.
DR   KEGG; dre:325106; -.
DR   CTD; 84135; -.
DR   ZFIN; ZDB-GENE-030131-3831; utp15.
DR   eggNOG; KOG0310; Eukaryota.
DR   GeneTree; ENSGT00390000004228; -.
DR   HOGENOM; CLU_021102_4_0_1; -.
DR   InParanoid; Q7ZW33; -.
DR   OMA; WKEHKQP; -.
DR   OrthoDB; 621827at2759; -.
DR   PhylomeDB; Q7ZW33; -.
DR   TreeFam; TF319494; -.
DR   Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q7ZW33; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 18.
DR   Bgee; ENSDARG00000002720; Expressed in gastrula and 28 other tissues.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IGI:ZFIN.
DR   GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR018983; U3_snoRNA-assocProt_15_C.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF09384; UTP15_C; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; rRNA processing; WD repeat.
FT   CHAIN           1..517
FT                   /note="U3 small nucleolar RNA-associated protein 15
FT                   homolog"
FT                   /id="PRO_0000051325"
FT   REPEAT          36..75
FT                   /note="WD 1"
FT   REPEAT          78..117
FT                   /note="WD 2"
FT   REPEAT          120..159
FT                   /note="WD 3"
FT   REPEAT          162..202
FT                   /note="WD 4"
FT   REPEAT          204..242
FT                   /note="WD 5"
FT   REPEAT          246..285
FT                   /note="WD 6"
FT   REPEAT          287..324
FT                   /note="WD 7"
FT   CONFLICT        504
FT                   /note="G -> GV (in Ref. 1; AAQ97804)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   517 AA;  57726 MW;  B9F33DB808C9C8B1 CRC64;
     MASFKPTKVL SYPKLGEKVT EETLYWKNYK PPVQIKEFGA VSKIDFSPLP PHNYAVTAST
     RVHIYGLHSQ EPIRNFTRFH DTAYGGSFRG DGKLLVAGSE EGLIRLFDIG GRVSLRQFKG
     HSKAVHATSF LSDGFRVLSG SDDLTCRVWD VASAVELSSI TEHTDYIRAI APSKLNPDVF
     VTGSYDHTVK MFDVRSGNSV MTMQHGQPVE CVLLYPSEAL LVSTGGRYVK VWDLLKGGQQ
     LVSLKNHHKT VTCACLSSSN KLLTASLDRH VKVYNSSYKV VHNFDCASSI LSLAVAPDDE
     AVAVGMTNGV LSIRHRKHKE EKEALTGRRK RGPSYRFFVK GKNFVPRQDD FLVSKPVRQH
     LQKYDKQLKR FEVSKALDTA LETWTRTTKP EVTVAVIMEL NRRGTLKNAL AGRDEVSLTK
     ILNFLLKHIT DPRFSRPLLT VGDIVLDLYQ QVIPQSPVVE RLLQRLYEIL GREAELQQEL
     LQVLGILDTL FASLMPRKEV ASFGAAAAAQ ESQLQAA