UTP15_MOUSE
ID UTP15_MOUSE Reviewed; 528 AA.
AC Q8C7V3; Q3TRG8; Q8K231;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=U3 small nucleolar RNA-associated protein 15 homolog;
DE AltName: Full=Src-associated protein SAW;
GN Name=Utp15;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Baker S.J.;
RT "SAW: a novel WD-repeat domain containing protein that associates with
RT Src.";
RL Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Ribosome biogenesis factor. Involved in nucleolar processing
CC of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA
CC transcription by RNA polymerase I. {ECO:0000250|UniProtKB:Q8TED0}.
CC -!- SUBUNIT: Interacts directly with UTP4 and WDR43 (). May be a component
CC of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU)
CC processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75.
CC {ECO:0000250|UniProtKB:Q8TED0}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q8TED0}. Note=Found predominantly at the
CC fibrillar center. {ECO:0000250|UniProtKB:Q8TED0}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH34372.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY151261; AAN71642.1; -; mRNA.
DR EMBL; AK049186; BAC33596.1; -; mRNA.
DR EMBL; AK162794; BAE37061.1; -; mRNA.
DR EMBL; BC034372; AAH34372.1; ALT_INIT; mRNA.
DR EMBL; BC065057; AAH65057.1; -; mRNA.
DR CCDS; CCDS26712.1; -.
DR RefSeq; NP_849249.1; NM_178918.3.
DR AlphaFoldDB; Q8C7V3; -.
DR SMR; Q8C7V3; -.
DR BioGRID; 222829; 4.
DR IntAct; Q8C7V3; 1.
DR STRING; 10090.ENSMUSP00000048204; -.
DR iPTMnet; Q8C7V3; -.
DR PhosphoSitePlus; Q8C7V3; -.
DR EPD; Q8C7V3; -.
DR jPOST; Q8C7V3; -.
DR MaxQB; Q8C7V3; -.
DR PaxDb; Q8C7V3; -.
DR PeptideAtlas; Q8C7V3; -.
DR PRIDE; Q8C7V3; -.
DR ProteomicsDB; 299664; -.
DR Antibodypedia; 44207; 63 antibodies from 17 providers.
DR DNASU; 105372; -.
DR Ensembl; ENSMUST00000040972; ENSMUSP00000048204; ENSMUSG00000041747.
DR GeneID; 105372; -.
DR KEGG; mmu:105372; -.
DR UCSC; uc007rom.1; mouse.
DR CTD; 84135; -.
DR MGI; MGI:2145443; Utp15.
DR VEuPathDB; HostDB:ENSMUSG00000041747; -.
DR eggNOG; KOG0267; Eukaryota.
DR eggNOG; KOG0310; Eukaryota.
DR GeneTree; ENSGT00390000004228; -.
DR HOGENOM; CLU_021102_4_1_1; -.
DR InParanoid; Q8C7V3; -.
DR OMA; WKEHKQP; -.
DR OrthoDB; 621827at2759; -.
DR PhylomeDB; Q8C7V3; -.
DR TreeFam; TF319494; -.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 105372; 28 hits in 71 CRISPR screens.
DR ChiTaRS; Utp15; mouse.
DR PRO; PR:Q8C7V3; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q8C7V3; protein.
DR Bgee; ENSMUSG00000041747; Expressed in manus and 225 other tissues.
DR Genevisible; Q8C7V3; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0001650; C:fibrillar center; ISS:UniProtKB.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:2000234; P:positive regulation of rRNA processing; ISO:MGI.
DR GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; ISO:MGI.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR018983; U3_snoRNA-assocProt_15_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF09384; UTP15_C; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Acetylation; Isopeptide bond; Nucleus; Reference proteome; Repeat;
KW Ribosome biogenesis; rRNA processing; Transcription;
KW Transcription regulation; Ubl conjugation; WD repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q8TED0"
FT CHAIN 2..528
FT /note="U3 small nucleolar RNA-associated protein 15
FT homolog"
FT /id="PRO_0000051322"
FT REPEAT 36..75
FT /note="WD 1"
FT REPEAT 78..117
FT /note="WD 2"
FT REPEAT 120..159
FT /note="WD 3"
FT REPEAT 162..202
FT /note="WD 4"
FT REPEAT 204..242
FT /note="WD 5"
FT REPEAT 246..285
FT /note="WD 6"
FT REPEAT 287..326
FT /note="WD 7"
FT REGION 496..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..528
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q8TED0"
FT CROSSLNK 249
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8TED0"
FT CONFLICT 479
FT /note="E -> K (in Ref. 3; AAH34372)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 528 AA; 59375 MW; 6C1691522D1919C5 CRC64;
MAGYKPVAIQ TYPVLGEKIT QDTLYWNNYK TPVQIKEFGA VSKVDFSPQL PYNYAVTASS
RIHIYGRYSQ EPVKTFSRFK DTAYCATFRQ DGQLLVAGSE DGVVQLFDIN GRAPLRQFEG
HTKAVHTVDF TADNYHVVSG ADDYTVKLWD IPNSKEILTF KEHSDYVRCG CASKLNPDLF
VTGSYDHTVK IFDARTNKNV LCVEHGQPVE SVLLFPSGGL LVSAGGRYVK VWDMLKGGQL
LVSLKNHHKT VTCLCLSSSG QRLLSGSLDR KVKVYSTTSY KVVHSFDYAA SILSLALSHQ
DETIVVGMTN GILSVKHRKS EAKKTSLPRR RRPAYRTFIK GKNYLKQRDD IMVSRPAKKH
LEGYDKDLKS FRVSQALDRV LEPKCVIRTP EVTVSIIKEL TRRGVLANAL AGRDEKEVTR
VLNFLIRNLS QPRFAPVLIN AAEIIIDIYL PVIGQSSVVD KKFIVLQELV EKEIDYQREL
LETLGMMDML FATMTRNDSD PVPEHVPAEL PEEKTESPTQ PSDTDKNS
