ID   UTP15_PONAB             Reviewed;         518 AA.
AC   Q5REE0;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 15 homolog;
GN   Name=UTP15;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Forms a complex with UTP4, NOL11, WDR43 and WDR75.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q8TED0}. Note=Found predominantly at the
CC       fibrillar center. {ECO:0000250|UniProtKB:Q8TED0}.
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DR   EMBL; CR857589; CAH89867.1; -; mRNA.
DR   RefSeq; NP_001124870.1; NM_001131398.1.
DR   AlphaFoldDB; Q5REE0; -.
DR   SMR; Q5REE0; -.
DR   STRING; 9601.ENSPPYP00000017381; -.
DR   GeneID; 100171733; -.
DR   KEGG; pon:100171733; -.
DR   CTD; 84135; -.
DR   eggNOG; KOG0267; Eukaryota.
DR   eggNOG; KOG0310; Eukaryota.
DR   InParanoid; Q5REE0; -.
DR   OrthoDB; 621827at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0001650; C:fibrillar center; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR018983; U3_snoRNA-assocProt_15_C.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF09384; UTP15_C; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Isopeptide bond; Nucleus; Reference proteome; Repeat;
KW   rRNA processing; Ubl conjugation; WD repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TED0"
FT   CHAIN           2..518
FT                   /note="U3 small nucleolar RNA-associated protein 15
FT                   homolog"
FT                   /id="PRO_0000051323"
FT   REPEAT          36..75
FT                   /note="WD 1"
FT   REPEAT          78..117
FT                   /note="WD 2"
FT   REPEAT          120..159
FT                   /note="WD 3"
FT   REPEAT          162..202
FT                   /note="WD 4"
FT   REPEAT          204..245
FT                   /note="WD 5"
FT   REPEAT          246..285
FT                   /note="WD 6"
FT   REPEAT          287..326
FT                   /note="WD 7"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TED0"
FT   CROSSLNK        249
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TED0"
SQ   SEQUENCE   518 AA;  58285 MW;  3DA2969AD9F6347F CRC64;
     MAGYKPVAIQ TYPILGEKIT QDTLYWNNYK TPVQIKEFGA VSKVDFSPQP PYNYAVTASS
     RIHIYGRYSQ ESIKTFSRFK DTAYCATFRQ DGRLIVAGSE DGGVQLFDIS GRAPLRQFEG
     HTKAVHTVDF TADKYHVVSG ADDYTVKLWD IPNSKEVLTF KEHSDYVRCG CASKLNPDLF
     ITGSYDHTVK MFDARTSESV LSVEHGQPVE SVLLFPSGGL LVSAGGRYVK VCDMLKGGQL
     LVSLKNHHKT VTCLCLSSSG QRLLSGSLDR KVKVYSTTSY KVVHSFDYAA SILSLALAHE
     DETIVVGMTN GILSVKHRKS EAKKESLPRR RRPAYRTFIK GKNYMKQRDD ILINRPAKKH
     LELYDRDLKH FRISKALDRV LDPTCTIKTP EITVSIIKEL NRRGVLANAL AGRDEKEISH
     VLNFLIRNLS QPRFAPVLIN AAEIIIDIYL PVIGQSPVVD KKFLLLQGLV EKEIDYQREL
     LETLGMMDML FATMRRKEGT SVLENTSDGF PENKKIES