ID   UTP15_RAT               Reviewed;         528 AA.
AC   A2RRU3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 15 homolog;
GN   Name=Utp15 {ECO:0000250|UniProtKB:Q8TED0};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAI31852.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart {ECO:0000312|EMBL:AAI31852.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       {ECO:0000250|UniProtKB:Q04305}.
CC   -!- SUBUNIT: Forms a complex with UTP4, NOL11, WDR43 and WDR75.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q8TED0}. Note=Found predominantly at the
CC       fibrillar center. {ECO:0000250|UniProtKB:Q8TED0}.
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DR   EMBL; BC131851; AAI31852.1; -; mRNA.
DR   RefSeq; NP_001101117.1; NM_001107647.2.
DR   RefSeq; XP_006231898.1; XM_006231836.3.
DR   RefSeq; XP_008758893.1; XM_008760671.2.
DR   RefSeq; XP_008758894.1; XM_008760672.2.
DR   RefSeq; XP_008758895.1; XM_008760673.2.
DR   AlphaFoldDB; A2RRU3; -.
DR   SMR; A2RRU3; -.
DR   STRING; 10116.ENSRNOP00000022259; -.
DR   jPOST; A2RRU3; -.
DR   PaxDb; A2RRU3; -.
DR   PeptideAtlas; A2RRU3; -.
DR   Ensembl; ENSRNOT00000022259; ENSRNOP00000022259; ENSRNOG00000016591.
DR   GeneID; 310019; -.
DR   KEGG; rno:310019; -.
DR   UCSC; RGD:1310992; rat.
DR   CTD; 84135; -.
DR   RGD; 1310992; Utp15.
DR   eggNOG; KOG0267; Eukaryota.
DR   eggNOG; KOG0310; Eukaryota.
DR   GeneTree; ENSGT00390000004228; -.
DR   HOGENOM; CLU_021102_4_1_1; -.
DR   InParanoid; A2RRU3; -.
DR   OMA; WKEHKQP; -.
DR   OrthoDB; 621827at2759; -.
DR   PhylomeDB; A2RRU3; -.
DR   TreeFam; TF319494; -.
DR   Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:A2RRU3; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000016591; Expressed in thymus and 18 other tissues.
DR   Genevisible; A2RRU3; RN.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001650; C:fibrillar center; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:2000234; P:positive regulation of rRNA processing; ISO:RGD.
DR   GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; ISO:RGD.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR018983; U3_snoRNA-assocProt_15_C.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF09384; UTP15_C; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Isopeptide bond; Nucleus; Reference proteome; Repeat;
KW   rRNA processing; Ubl conjugation; WD repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TED0"
FT   CHAIN           2..528
FT                   /note="U3 small nucleolar RNA-associated protein 15
FT                   homolog"
FT                   /id="PRO_0000314596"
FT   REPEAT          36..75
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          78..117
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          120..159
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          162..202
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          204..242
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          246..285
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          287..326
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REGION          508..528
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TED0"
FT   CROSSLNK        249
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TED0"
SQ   SEQUENCE   528 AA;  59515 MW;  65CA7A97CC5B709B CRC64;
     MAGYKPVVIQ TYPVLGEKIT QDTLYWNNYK TPVQIKEFGA VSKVDFSPQP PYNYAVTASS
     RIHIYGRYSQ EPVKTFSRFK DTAYCATFRQ DGQLLVAGSE DGVVQLFDIS GRAPLRQFEG
     HTKAVHTVDF TADKYHVVSG ADDYTVKLWD IPNSKEILTF KEHSDYVRCG CASKLNPDLF
     VTGSYDHTVK MFDARTNKNV LCVEHGQPVE SVLLFPSGGL LVSAGGRYVK VWDMLKGGQL
     LVSLKNHHKT VTCLCLSSSG QRLLSGSLDR KVKIYSTTSY KVVHSFDYAA SILSLALSHQ
     DETVVVGMTN GILSVKHRKS EAKKESLPRR RRPAYRTFIK GKIYTKQRDD IVVTRPAKKH
     LEWYDRDLKS FRISKALDRV LEPNCVIKTP EVTVSIIKEL NRRGVLANAL AGRDEKEITR
     VLNFLIRNLS QPRFAPVLIN AAEIIIDIYL PVIGQSSVVD KKFIVLQGLV EKEIDYQREL
     LETLGMMDML FATMTRNGSA PVWEHVPAEL PEEKTESPRQ PSDTDKNS