ID   UTP15_SCHPO             Reviewed;         494 AA.
AC   O94365;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 15;
DE            Short=U3 snoRNA-associated protein 15;
DE   AltName: Full=U3 protein 15 required for transcription;
GN   Name=utp15; ORFNames=SPBC428.19c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1] {ECO:0000312|EMBL:CAA22294.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2] {ECO:0000305}
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       Required for optimal pre-ribosomal RNA transcription by RNA polymerase
CC       I together with a subset of U3 proteins required for transcription (t-
CC       UTPs) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC       {ECO:0000250|UniProtKB:Q04305}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
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DR   EMBL; CU329671; CAA22294.1; -; Genomic_DNA.
DR   PIR; T40471; T40471.
DR   RefSeq; NP_595197.1; NM_001021104.2.
DR   AlphaFoldDB; O94365; -.
DR   SMR; O94365; -.
DR   BioGRID; 277375; 4.
DR   STRING; 4896.SPBC428.19c.1; -.
DR   iPTMnet; O94365; -.
DR   MaxQB; O94365; -.
DR   PaxDb; O94365; -.
DR   PRIDE; O94365; -.
DR   EnsemblFungi; SPBC428.19c.1; SPBC428.19c.1:pep; SPBC428.19c.
DR   GeneID; 2540858; -.
DR   KEGG; spo:SPBC428.19c; -.
DR   PomBase; SPBC428.19c; utp15.
DR   VEuPathDB; FungiDB:SPBC428.19c; -.
DR   eggNOG; KOG0310; Eukaryota.
DR   HOGENOM; CLU_021102_4_0_1; -.
DR   InParanoid; O94365; -.
DR   OMA; WKEHKQP; -.
DR   PhylomeDB; O94365; -.
DR   Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:O94365; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0072686; C:mitotic spindle; HDA:PomBase.
DR   GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR   GO; GO:0032040; C:small-subunit processome; ISO:PomBase.
DR   GO; GO:0034455; C:t-UTP complex; ISO:PomBase.
DR   GO; GO:0030515; F:snoRNA binding; ISO:PomBase.
DR   GO; GO:0030490; P:maturation of SSU-rRNA; ISO:PomBase.
DR   GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR018983; U3_snoRNA-assocProt_15_C.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF09384; UTP15_C; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing; Transcription; WD repeat.
FT   CHAIN           1..494
FT                   /note="U3 small nucleolar RNA-associated protein 15"
FT                   /id="PRO_0000307922"
FT   REPEAT          37..76
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          79..118
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          121..161
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          164..202
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          205..243
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          248..287
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          289..328
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   494 AA;  54112 MW;  3D3C484C12950B31 CRC64;
     MSAPAGRLQP QRFAALPNPV TAENKFWRSF KVPVVAKEYS AITSIHFSAE SPYDFAVTSG
     ARVQIYGASS RSVKKTIARF KDTAYSGNIR KDGKLLLAGD ATGLVQIFDL STRSILRALD
     AHQFPVHVTQ FCPYANTTFL SGSDDKTVKV WDLSTGAVQY DLSGHEDYVR TASWMSATRL
     VSGGYDGTIR LWDTRIADPE VMSFSHGEAI DVVLPMQSGS TVISAGGPSI KVWDLVAGRQ
     TPTKKLSNHQ KSITCLAMNS ENTRLLSGGL DGHVKIYNIS DWKVVHGMKY SGPILSMGLS
     PDSCNLVVGM SNGTLSQRTR RITKQTSSKT PFLGGVGSAF GVVGKKKQIY KGENDEFYVE
     EARRKRLRPF DKALKSFCYS DALDMVLENG SPVLIITMLI ELLHVGGLRI ALSNRDDLSL
     TPLINFLRKY IRDPRFSETL CIVTSTILDI YGAALGGSVM VENAISKLRE KVEQEVAVTQ
     RANELVGMLQ MLSA