ID   UTP15_XENLA             Reviewed;         515 AA.
AC   Q7ZXZ2;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 15 homolog;
GN   Name=utp15;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Ribosome biogenesis factor. Involved in nucleolar processing
CC       of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA
CC       transcription by RNA polymerase I. {ECO:0000250|UniProtKB:Q8TED0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q8TED0}.
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DR   EMBL; BC044048; AAH44048.1; -; mRNA.
DR   RefSeq; NP_001080168.1; NM_001086699.1.
DR   RefSeq; XP_018122551.1; XM_018267062.1.
DR   RefSeq; XP_018122629.1; XM_018267140.1.
DR   AlphaFoldDB; Q7ZXZ2; -.
DR   SMR; Q7ZXZ2; -.
DR   MaxQB; Q7ZXZ2; -.
DR   PRIDE; Q7ZXZ2; -.
DR   DNASU; 379860; -.
DR   GeneID; 379860; -.
DR   KEGG; xla:379860; -.
DR   CTD; 379860; -.
DR   Xenbase; XB-GENE-866061; utp15.L.
DR   OMA; WKEHKQP; -.
DR   OrthoDB; 621827at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 379860; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR018983; U3_snoRNA-assocProt_15_C.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF09384; UTP15_C; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; rRNA processing; WD repeat.
FT   CHAIN           1..515
FT                   /note="U3 small nucleolar RNA-associated protein 15
FT                   homolog"
FT                   /id="PRO_0000051326"
FT   REPEAT          36..75
FT                   /note="WD 1"
FT   REPEAT          78..117
FT                   /note="WD 2"
FT   REPEAT          120..159
FT                   /note="WD 3"
FT   REPEAT          162..202
FT                   /note="WD 4"
FT   REPEAT          204..242
FT                   /note="WD 5"
FT   REPEAT          246..285
FT                   /note="WD 6"
FT   REPEAT          287..326
FT                   /note="WD 7"
SQ   SEQUENCE   515 AA;  58235 MW;  38AEB01B109EFFE0 CRC64;
     MSSYKPLAIP TYPKLGEKIT QDTLYWKRYK TPVQIKEFGA VTKIHFSPIQ PFSYAVTSST
     RIHLYGQYSQ EPVKTFSRFK DTAYCGTYRG DGKLLAAGCE DSVVQLFDIS GKAALRQFSG
     HSKAVHFVDF TSDKYRIVSG SDDYTSKLWD IPNGIEIASY KEHTDYIRCG CTSSLNNDLF
     ATGSYDHTIK VFDGRTDKSV MSMDHGQPVE SVLLFPSGGL LVSAGGRYVK VWDILKGGQL
     LVSLRNHHKT VTCLCLSSSG QRLLSGSLDR HVKVYSTMNY KVVHSFDYAA SILSLALAPD
     DQMIVVGMTN GVLNIKHRKP EERKPLQSTT KRHPRYRVFV RGKDYMPKQD DIYVSKPVRE
     HLKKYDQLLK GFHMSKALDA VLQSQIRTKK PEVTVAVMNE LKRRGTLKNA LAGRNEKELS
     DLLIFLLKHL VNPLFLPILL NVAEHIIDIY SPVVGQSSVI HKQFIRLQEV VEKEINYQEE
     LLKILGMMDT LFATMTTKKE SPWEEPKPIL PLGSQ