UTP17_SCHPO
ID UTP17_SCHPO Reviewed; 806 AA.
AC O13878;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 3.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=U3 small nucleolar RNA-associated protein 17;
DE Short=U3 snoRNA-associated protein 17;
DE AltName: Full=U3 protein 17 required for transcription;
GN Name=utp17; ORFNames=SPAC1B3.13;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [3] {ECO:0000305}
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC Required for optimal pre-ribosomal RNA transcription by RNA polymerase
CC I together with a subset of U3 proteins required for transcription (t-
CC UTPs) (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC {ECO:0000250|UniProtKB:Q02931}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329670; CAB11248.2; -; Genomic_DNA.
DR PIR; T38032; T38032.
DR RefSeq; NP_594798.2; NM_001020226.2.
DR AlphaFoldDB; O13878; -.
DR SMR; O13878; -.
DR BioGRID; 278691; 5.
DR STRING; 4896.SPAC1B3.13.1; -.
DR MaxQB; O13878; -.
DR PaxDb; O13878; -.
DR EnsemblFungi; SPAC1B3.13.1; SPAC1B3.13.1:pep; SPAC1B3.13.
DR GeneID; 2542217; -.
DR KEGG; spo:SPAC1B3.13; -.
DR PomBase; SPAC1B3.13; -.
DR VEuPathDB; FungiDB:SPAC1B3.13; -.
DR eggNOG; KOG1963; Eukaryota.
DR HOGENOM; CLU_403137_0_0_1; -.
DR InParanoid; O13878; -.
DR OMA; TSHRQFL; -.
DR Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:O13878; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0032040; C:small-subunit processome; ISO:PomBase.
DR GO; GO:0034455; C:t-UTP complex; ISO:PomBase.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0030515; F:snoRNA binding; ISO:PomBase.
DR GO; GO:0030490; P:maturation of SSU-rRNA; ISO:PomBase.
DR GO; GO:2000234; P:positive regulation of rRNA processing; IBA:GO_Central.
DR GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR SMART; SM00320; WD40; 2.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF50998; SSF50998; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; rRNA processing; Transcription; WD repeat.
FT CHAIN 1..806
FT /note="U3 small nucleolar RNA-associated protein 17"
FT /id="PRO_0000307923"
FT REPEAT 266..305
FT /note="WD 1"
FT REPEAT 448..489
FT /note="WD 2"
FT REPEAT 499..538
FT /note="WD 3"
FT REPEAT 598..635
FT /note="WD 4"
SQ SEQUENCE 806 AA; 88938 MW; AB7E35C821F63B32 CRC64;
MEGPNSMEVG SLEVKKNDKD PWSKTAYLGG RLVSKIPAVY SNDNKFVFLT YDTFIGIFSL
ITGDCINRIF FPNNLANLLP VAVLLSPENA FELYVIFQSG YVCVHDWSNS ELLRTMEIST
RVHAASFSGK LLFAVTDTPA SDSASSQDRF TLYALSPSTS KEGSSILIPT FVSKFNEFLA
LDSSLRDNNL ATVAVITTDK AIFSLNVPKK KRSQRWIHRE HLFNMPQKLT NVSLCGSACA
VSDDEGKIHV INDISNEKFN PQILHWHANP LNGLSWALNG EYLLSGGQEG VLVLWQMETS
HRQFLPRLGS SILSIATSHD SDSYALHLGD NSLVVIRAVD LAEQIHVSGI NSFESKYLTS
TGPKNTSKQL QGLVQFSSVS PNGELLLMSS SSFNGHSVSV QEYDLTKDST IRKFEAARYS
YSSVSKNSDD ATSLDNGHVG SVAVTSSRNG LYIATIDTWC TNIIDEQQRN VKQTALKFWQ
FDSVQKTWVL MTRIDNPHGN LEVVTALKMM TSSNRFITVG TDATLRIWAL LPGSSAWKCV
AIHHFANTHS QASIKQRYGF SKALTCSLDD SIIGFGYGSC MHFINSETLE EISTVDLPHG
GQLENAQFLN AEHCVIISQR RLLVWNVISA SVQWTLASKF TGLLASSSSG NDFAVIDFNS
SYSRLIIFSP DSPKIQSIHI FKTLPVALHY LHGGFVVLDN KSIIHVYAGD LTTKIPSAQL
SIDNTSRSLL GDFQKRNVPL LNLENPISGS QGLHYKRLTT DMIHNLFNVP SNSPVNMQAI
YNTFSKMAVG EPMESLGTQI ATLNTE