ID   UTP18_CAEEL             Reviewed;         429 AA.
AC   P42000;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 18 homolog;
GN   ORFNames=B0280.9;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat UTP18 family. {ECO:0000305}.
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DR   EMBL; FO080148; CCD61605.1; -; Genomic_DNA.
DR   PIR; T15303; T15303.
DR   RefSeq; NP_498555.1; NM_066154.5.
DR   AlphaFoldDB; P42000; -.
DR   SMR; P42000; -.
DR   BioGRID; 41206; 13.
DR   STRING; 6239.B0280.9; -.
DR   EPD; P42000; -.
DR   PaxDb; P42000; -.
DR   PeptideAtlas; P42000; -.
DR   PRIDE; P42000; -.
DR   EnsemblMetazoa; B0280.9.1; B0280.9.1; WBGene00015104.
DR   GeneID; 175994; -.
DR   KEGG; cel:CELE_B0280.9; -.
DR   UCSC; B0280.9; c. elegans.
DR   CTD; 175994; -.
DR   WormBase; B0280.9; CE00816; WBGene00015104; -.
DR   eggNOG; KOG2055; Eukaryota.
DR   GeneTree; ENSGT00940000165670; -.
DR   HOGENOM; CLU_011055_3_0_1; -.
DR   InParanoid; P42000; -.
DR   OMA; QFHPTST; -.
DR   OrthoDB; 462558at2759; -.
DR   PhylomeDB; P42000; -.
DR   Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:P42000; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00015104; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0034388; C:Pwp2p-containing subcomplex of 90S preribosome; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR045161; Utp18.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR18359; PTHR18359; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; rRNA processing; WD repeat.
FT   CHAIN           1..429
FT                   /note="U3 small nucleolar RNA-associated protein 18
FT                   homolog"
FT                   /id="PRO_0000051408"
FT   REPEAT          117..156
FT                   /note="WD 1"
FT   REPEAT          295..336
FT                   /note="WD 2"
FT   REPEAT          345..386
FT                   /note="WD 3"
FT   REPEAT          392..428
FT                   /note="WD 4"
SQ   SEQUENCE   429 AA;  47772 MW;  E4D0154305A65DED CRC64;
     MSKRPVIESE KPAWHDEDDD NMVVAVPKKV KMTMRVELKR TTDEEHGELD SKEYVGRLQE
     AFRKRHGGTP KWAKAAAGDE EEGSLLKTAA GYLAKDVNLP KTTIHTTLIK DFNIGHRYTR
     GITVVKFHKT RPVLIVADQG GNVQLFKVSR EVKKDRFLQS ANFSKFPIDS LEIADKGHSV
     ICSSSRKEYL MQYNMETREV TQLKPPNTVP KQGIRLFAIS HDSQFLAIAG HNSHIYVLHA
     TSMEHITTIS LPANASEIKF FPSHSREIWI ICETGQIVIA NIGLPGTKSS QHTFTDDGAV
     HGTTLAISQH GDYFATGSDT GIVNVYSGND CRNSTNPRPL FNVSNLVTAV SSIAFNSDAQ
     LMAICSNVKD NHLRLVHVAS QTTFKNFPER NGKVTHARCV EFSPNGGYMA VGNDDGRLHV
     FEIHHFTDY