ID   UTP18_SCHPO             Reviewed;         519 AA.
AC   P78750;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 3.
DT   25-MAY-2022, entry version 138.
DE   RecName: Full=Probable U3 small nucleolar RNA-associated protein 18;
DE            Short=U3 snoRNA-associated protein 18;
GN   ORFNames=SPBC29A3.06;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 269-519.
RC   STRAIN=PR745;
RX   PubMed=9501991; DOI=10.1093/dnares/4.6.363;
RA   Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
RT   "Identification of open reading frames in Schizosaccharomyces pombe
RT   cDNAs.";
RL   DNA Res. 4:363-369(1997).
RN   [3]
RP   IDENTIFICATION OF FRAMESHIFT.
RC   STRAIN=972 / ATCC 24843, and JY3;
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat UTP18 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA18383.2; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; CU329671; CAA18383.2; ALT_FRAME; Genomic_DNA.
DR   EMBL; D89098; BAA13761.1; -; mRNA.
DR   PIR; T40077; T40077.
DR   PIR; T42005; T42005.
DR   RefSeq; NP_595834.2; NM_001021738.2.
DR   AlphaFoldDB; P78750; -.
DR   SMR; P78750; -.
DR   BioGRID; 277057; 2.
DR   STRING; 4896.SPBC29A3.06.1; -.
DR   iPTMnet; P78750; -.
DR   MaxQB; P78750; -.
DR   PaxDb; P78750; -.
DR   GeneID; 2540529; -.
DR   KEGG; spo:SPBC29A3.06; -.
DR   PomBase; SPBC29A3.06; -.
DR   eggNOG; KOG2055; Eukaryota.
DR   HOGENOM; CLU_011055_1_0_1; -.
DR   InParanoid; P78750; -.
DR   PhylomeDB; P78750; -.
DR   Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:P78750; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0034388; C:Pwp2p-containing subcomplex of 90S preribosome; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; ISO:PomBase.
DR   GO; GO:0006364; P:rRNA processing; ISO:PomBase.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR045161; Utp18.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR18359; PTHR18359; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; rRNA processing; WD repeat.
FT   CHAIN           1..519
FT                   /note="Probable U3 small nucleolar RNA-associated protein
FT                   18"
FT                   /id="PRO_0000051329"
FT   REPEAT          26..66
FT                   /note="WD 1"
FT   REPEAT          71..111
FT                   /note="WD 2"
FT   REPEAT          216..254
FT                   /note="WD 3"
FT   REPEAT          259..298
FT                   /note="WD 4"
FT   REPEAT          306..345
FT                   /note="WD 5"
FT   REPEAT          347..386
FT                   /note="WD 6"
FT   REPEAT          390..429
FT                   /note="WD 7"
FT   REPEAT          438..479
FT                   /note="WD 8"
FT   REPEAT          485..519
FT                   /note="WD 9"
SQ   SEQUENCE   519 AA;  58445 MW;  ECC98FC114AE4C61 CRC64;
     MEKDTEELEL ENAVFGNINN FSSFLDKENE TFDVMMNEAP ELSEDNDAQE DELEKLEDAE
     LFMFDTGSAD GAKDSVPLDI IAGDNTVKED EEASNEIPSI WEDSDDERLM ISLQDHSRLR
     KLRQYEDEDM VNGLQYARRL RTQFERVYPV PEWAKKQDVT EEEDEFNALS EKSVIPKSLK
     SLFKSSVSYI NQSSKLLAPG TINIKRLKDA NFQAPSHSGI RCMSIHPYFP LLLTCGFDRT
     LRIYQLDGKV NPLVTSLHLR SSALQTALFH PDGKRVIAAG RRKYMYIWDL ESAQVQKVSR
     MYGQENFQPS MERFHVDPTG KYIALEGRSG HINLLHALTG QFATSFKIEG VLSDVLFTSD
     GSEMLVLSYG AEVWHFNVEQ RSVVRRWQVQ DGVSTTHFCL DPSNKYLAIG SKSGIVNIYD
     LQTSNADAAP KPVTTLDNIT FSINSMSFSQ DSQVLAIASR GKKDTLRLVH VPSFSVFRNW
     PTSATPLGRV TCLAFGKGGE LCVGNEAGRV GLWKLAHYD