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UTP20_SCHPO
ID   UTP20_SCHPO             Reviewed;        2493 AA.
AC   O60055;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 20;
DE            Short=U3 snoRNA-associated protein 20;
GN   Name=utp20; ORFNames=SPBC56F2.04;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA and
CC       ribosome assembly. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with snoRNA U3. Component of the ribosomal small
CC       subunit (SSU) processome composed of at least 40 protein subunits and
CC       snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the UTP20 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA18883.1; -; Genomic_DNA.
DR   PIR; T40540; T40540.
DR   RefSeq; NP_596713.1; NM_001022638.2.
DR   AlphaFoldDB; O60055; -.
DR   SMR; O60055; -.
DR   BioGRID; 277359; 3.
DR   STRING; 4896.SPBC56F2.04.1; -.
DR   iPTMnet; O60055; -.
DR   MaxQB; O60055; -.
DR   PaxDb; O60055; -.
DR   PRIDE; O60055; -.
DR   EnsemblFungi; SPBC56F2.04.1; SPBC56F2.04.1:pep; SPBC56F2.04.
DR   GeneID; 2540842; -.
DR   KEGG; spo:SPBC56F2.04; -.
DR   PomBase; SPBC56F2.04; utp20.
DR   VEuPathDB; FungiDB:SPBC56F2.04; -.
DR   eggNOG; KOG1823; Eukaryota.
DR   HOGENOM; CLU_000327_0_0_1; -.
DR   InParanoid; O60055; -.
DR   OMA; LAWIFKF; -.
DR   PhylomeDB; O60055; -.
DR   Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:O60055; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0030688; C:preribosome, small subunit precursor; ISO:PomBase.
DR   GO; GO:0032040; C:small-subunit processome; ISO:PomBase.
DR   GO; GO:0030515; F:snoRNA binding; ISO:PomBase.
DR   GO; GO:0006364; P:rRNA processing; ISO:PomBase.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR011430; DRIM.
DR   Pfam; PF07539; DRIM; 1.
DR   SUPFAM; SSF48371; SSF48371; 3.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..2493
FT                   /note="U3 small nucleolar RNA-associated protein 20"
FT                   /id="PRO_0000316028"
FT   REPEAT          265..303
FT                   /note="HEAT 1"
FT   REPEAT          402..439
FT                   /note="HEAT 2"
FT   REPEAT          568..605
FT                   /note="HEAT 3"
FT   REPEAT          913..957
FT                   /note="HEAT 4"
FT   REPEAT          1145..1186
FT                   /note="HEAT 5"
FT   REPEAT          1221..1262
FT                   /note="HEAT 6"
FT   REPEAT          1400..1437
FT                   /note="HEAT 7"
FT   REPEAT          1605..1645
FT                   /note="HEAT 8"
FT   REPEAT          1647..1687
FT                   /note="HEAT 9"
FT   REPEAT          1896..1933
FT                   /note="HEAT 10"
FT   REPEAT          2082..2120
FT                   /note="HEAT 11"
FT   REGION          2463..2493
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          2393..2454
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        2466..2493
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2493 AA;  285227 MW;  3268BB4571297362 CRC64;
     MKAAAQSNSK NYVFLPFSKR VENLKIDVAH KIPRAADLED EDVESYFISC LRKWEDLNLS
     THYVNFLRSV TPYSQSLPQI VYHQKTIFDL IVQYAREGDS LSLQPILELL TQFARDLALE
     FASYIDQTLE LLCILVQNNE LEVVDWSFHA AAYLFKYLRK ILAPRLIHTY DILSPLLGKE
     KQKSHVTRFT AEALSFLCKT VSYENAIEFT GHVLLDLNDH YTPQYHEGVV ILFSRIIQGV
     DTSIHFKGKA FFEILLRSEI YTLPRSKSVI IPVLISTIHH CTSDSFNELE KLIISKITGE
     PLLYINLFKA TLVTRKGSRV SDYPSFFKAY LQIPNLVSWE NIESDLSVLI FEISALLFVY
     PQISDLMPHT VRIISFLQQG PLHLFFSFVD VVKQLNMQRY DSFIKPSLPK FISSLVSDES
     QKSLAILESV LDNSVPVPVD VASVSLNHFV YCIERLQIVS PSYEDIISLW SSLMIIISSS
     LGSDEIYKAC LLFLRKLEDV SSESVLLGDI CGIVLHLLQR KVSRLFLDSS YYKPILDSLL
     GVFGFLADSK VFLESIRPFF GTSYDFCSSY TSLMDRLINN LSRGLTSLRA ASIDLIIALC
     KSLQKNEVLQ SLSLVKKLSE LPFDPSTSRD ASVLLRNLSA KSSALEKDTR RVVLHALLGL
     TITRFTPLWP DLSRTAASIV TKEVEDEFLA IIYSWLSLPS PPSGLLGPTD TAVFVKPDLS
     LEKLPTLEIN TFNCPAISYF ETSFDECFSK FASSDNYIIG NLLKTNQEDL SNLPTFRSQA
     LRVLNELPEI ASRNINVLDN YLFSLQHGFD LNTEWARPDV YLLLGLYSKF TGIKEFVNRD
     ARKEFFLWAL TINDPKVQKL VLDIILLYSE EAITTYEENL RNLLDDKKCR DELITFLFVD
     YADSKIQDIH RPLLMPVVIS ILYGKMVSKG YGGQKNQAAR RSTILSALGN MQVEDLQILV
     DIMLRPYNGL EVKLNANNNL EIDTGNIPSL TLRRQIGFLT MTEELLLQIS SKLSSVAPKI
     LNAVLYNLVV SDDQISSQEA FENFEVKMAY TVRQLSLKVF LLFLKSCSDV DFKPYNVFIY
     TAFVVPRLDR FADENTQSVS NLMKIFRCWF ENEAYLDSVL EFSSHILTAL LNTASHTAVK
     LPVLLYILDT LNLVITHLQS EESESQLREK ILANLVMPNI TLIFASLSNI LKNPQFCNNN
     RVMDGSVQAL SAVSEYMSLD IDSSPLLNLL VSFLRKPNRL VPSNVKSNIL VLLCKLLPTN
     TKWLHASISQ TNDFDTIMHL YTSMVDIKAR QHLNDLLKIY STIDDNLIFS SVFVEEINSI
     SKKRLDEPDF ERRLSAFTSF NEKHFSLISD LAWLPVLYNF FFYVQDAEEL AIRASASLGI
     KRFIESITMN DASNQFKIDV FVKFIFPFIK NQMKNKNELI RQEFIGLLSY SIKSLTMVDA
     ISDMQPLLYE GDEEANFFNN ILHIQLHRRK RAMKRLVNVC AIGVIRSGNI SQIFLPLLEN
     FCLGNDTVQT LLDESVITIG EIIKWAHWNQ YQAILKRYVS LLKNNAIDQK VVVRLITAVV
     SALRPLDDAV ASYTNSEMNI EQFDGQKKKC VLASSLPSEE RFTEVLTNDF FPTLMLYLHI
     RDESTVTLRV AIALSIVQLV ALLPEEEIVL RLTPVLIDTC HILRSRSLES RDATRKALAA
     ISKFLGPKYF SFIISQLQTS LKRGYQLHVL GYTVHYLLLA IEDVYPYGSI DYCMDSLAQI
     FVDEIFGEVG VEKDSEDYKS NVKEIKGNKS YDSYEIVARI SSFDSLSTLL RPVKNVLFET
     NVPKSLRKVD ELCRRLSLGI VANKQSASQS SLIFCYNVYE FVVKEKETVA ALKQQENDGY
     RSAPNFFLEN SKKLIRFTFD VLRGVSNKHK ELLTARNMAA FVPLIGESLL SSSEEVQISA
     LRFLVLLLPL KIDQVFSGSS VFTSQAVKYI QNSPSTNTEL CQASFKFLAS ILPYENVKIK
     ESTINYLLER VGTDIQEPDR QGVMFSLVRA VIARKIMTPE LYKIIDLIRD MMVTNHTKST
     RQTCRHLYYS FLLDYPQGKT RLSKQISFIL KNLEYEFAPG RESVMELLHL ILNNFSDALL
     KEYHQGIFIA LVMVLANDSE PHCREMSAEL IKLVYQRADN ENFNLIRQLL SHWTSVEKAG
     KNLVRVSMQL FGLLFETFGF ERMEEVHLFT KVFERVLSTT ISHPEEATNE WELNYFGLQS
     WLKLVLADPK KSCEKEFSKI WESMRYLILF KHAWVRLSVS RLFGHFFAII GDSNFGKLSL
     GIDGVVFSLD FVTQISNALQ AQLRSPVLSE ELGMQVAKNL IFLTRWFNSI RSSDDSPFLE
     IFRRMRKTLK KQTIEEYSIN KKYLMQWFAS VIHVFSGEEL QPVLSEIIAA LYRYTELQEA
     ERKSQQELAD LVTESLQVLQ EKVGATVFAR AYQEVRNAAI EVRRERREKR AIEQVVAPEV
     ASRKKIRKNE RKRENRKQKT NHHRMVNSIF KNR
 
 
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