UTP20_SCHPO
ID UTP20_SCHPO Reviewed; 2493 AA.
AC O60055;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=U3 small nucleolar RNA-associated protein 20;
DE Short=U3 snoRNA-associated protein 20;
GN Name=utp20; ORFNames=SPBC56F2.04;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA and
CC ribosome assembly. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with snoRNA U3. Component of the ribosomal small
CC subunit (SSU) processome composed of at least 40 protein subunits and
CC snoRNA U3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the UTP20 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA18883.1; -; Genomic_DNA.
DR PIR; T40540; T40540.
DR RefSeq; NP_596713.1; NM_001022638.2.
DR AlphaFoldDB; O60055; -.
DR SMR; O60055; -.
DR BioGRID; 277359; 3.
DR STRING; 4896.SPBC56F2.04.1; -.
DR iPTMnet; O60055; -.
DR MaxQB; O60055; -.
DR PaxDb; O60055; -.
DR PRIDE; O60055; -.
DR EnsemblFungi; SPBC56F2.04.1; SPBC56F2.04.1:pep; SPBC56F2.04.
DR GeneID; 2540842; -.
DR KEGG; spo:SPBC56F2.04; -.
DR PomBase; SPBC56F2.04; utp20.
DR VEuPathDB; FungiDB:SPBC56F2.04; -.
DR eggNOG; KOG1823; Eukaryota.
DR HOGENOM; CLU_000327_0_0_1; -.
DR InParanoid; O60055; -.
DR OMA; LAWIFKF; -.
DR PhylomeDB; O60055; -.
DR Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:O60055; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0030688; C:preribosome, small subunit precursor; ISO:PomBase.
DR GO; GO:0032040; C:small-subunit processome; ISO:PomBase.
DR GO; GO:0030515; F:snoRNA binding; ISO:PomBase.
DR GO; GO:0006364; P:rRNA processing; ISO:PomBase.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011430; DRIM.
DR Pfam; PF07539; DRIM; 1.
DR SUPFAM; SSF48371; SSF48371; 3.
PE 3: Inferred from homology;
KW Coiled coil; Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; rRNA processing.
FT CHAIN 1..2493
FT /note="U3 small nucleolar RNA-associated protein 20"
FT /id="PRO_0000316028"
FT REPEAT 265..303
FT /note="HEAT 1"
FT REPEAT 402..439
FT /note="HEAT 2"
FT REPEAT 568..605
FT /note="HEAT 3"
FT REPEAT 913..957
FT /note="HEAT 4"
FT REPEAT 1145..1186
FT /note="HEAT 5"
FT REPEAT 1221..1262
FT /note="HEAT 6"
FT REPEAT 1400..1437
FT /note="HEAT 7"
FT REPEAT 1605..1645
FT /note="HEAT 8"
FT REPEAT 1647..1687
FT /note="HEAT 9"
FT REPEAT 1896..1933
FT /note="HEAT 10"
FT REPEAT 2082..2120
FT /note="HEAT 11"
FT REGION 2463..2493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2393..2454
FT /evidence="ECO:0000255"
FT COMPBIAS 2466..2493
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2493 AA; 285227 MW; 3268BB4571297362 CRC64;
MKAAAQSNSK NYVFLPFSKR VENLKIDVAH KIPRAADLED EDVESYFISC LRKWEDLNLS
THYVNFLRSV TPYSQSLPQI VYHQKTIFDL IVQYAREGDS LSLQPILELL TQFARDLALE
FASYIDQTLE LLCILVQNNE LEVVDWSFHA AAYLFKYLRK ILAPRLIHTY DILSPLLGKE
KQKSHVTRFT AEALSFLCKT VSYENAIEFT GHVLLDLNDH YTPQYHEGVV ILFSRIIQGV
DTSIHFKGKA FFEILLRSEI YTLPRSKSVI IPVLISTIHH CTSDSFNELE KLIISKITGE
PLLYINLFKA TLVTRKGSRV SDYPSFFKAY LQIPNLVSWE NIESDLSVLI FEISALLFVY
PQISDLMPHT VRIISFLQQG PLHLFFSFVD VVKQLNMQRY DSFIKPSLPK FISSLVSDES
QKSLAILESV LDNSVPVPVD VASVSLNHFV YCIERLQIVS PSYEDIISLW SSLMIIISSS
LGSDEIYKAC LLFLRKLEDV SSESVLLGDI CGIVLHLLQR KVSRLFLDSS YYKPILDSLL
GVFGFLADSK VFLESIRPFF GTSYDFCSSY TSLMDRLINN LSRGLTSLRA ASIDLIIALC
KSLQKNEVLQ SLSLVKKLSE LPFDPSTSRD ASVLLRNLSA KSSALEKDTR RVVLHALLGL
TITRFTPLWP DLSRTAASIV TKEVEDEFLA IIYSWLSLPS PPSGLLGPTD TAVFVKPDLS
LEKLPTLEIN TFNCPAISYF ETSFDECFSK FASSDNYIIG NLLKTNQEDL SNLPTFRSQA
LRVLNELPEI ASRNINVLDN YLFSLQHGFD LNTEWARPDV YLLLGLYSKF TGIKEFVNRD
ARKEFFLWAL TINDPKVQKL VLDIILLYSE EAITTYEENL RNLLDDKKCR DELITFLFVD
YADSKIQDIH RPLLMPVVIS ILYGKMVSKG YGGQKNQAAR RSTILSALGN MQVEDLQILV
DIMLRPYNGL EVKLNANNNL EIDTGNIPSL TLRRQIGFLT MTEELLLQIS SKLSSVAPKI
LNAVLYNLVV SDDQISSQEA FENFEVKMAY TVRQLSLKVF LLFLKSCSDV DFKPYNVFIY
TAFVVPRLDR FADENTQSVS NLMKIFRCWF ENEAYLDSVL EFSSHILTAL LNTASHTAVK
LPVLLYILDT LNLVITHLQS EESESQLREK ILANLVMPNI TLIFASLSNI LKNPQFCNNN
RVMDGSVQAL SAVSEYMSLD IDSSPLLNLL VSFLRKPNRL VPSNVKSNIL VLLCKLLPTN
TKWLHASISQ TNDFDTIMHL YTSMVDIKAR QHLNDLLKIY STIDDNLIFS SVFVEEINSI
SKKRLDEPDF ERRLSAFTSF NEKHFSLISD LAWLPVLYNF FFYVQDAEEL AIRASASLGI
KRFIESITMN DASNQFKIDV FVKFIFPFIK NQMKNKNELI RQEFIGLLSY SIKSLTMVDA
ISDMQPLLYE GDEEANFFNN ILHIQLHRRK RAMKRLVNVC AIGVIRSGNI SQIFLPLLEN
FCLGNDTVQT LLDESVITIG EIIKWAHWNQ YQAILKRYVS LLKNNAIDQK VVVRLITAVV
SALRPLDDAV ASYTNSEMNI EQFDGQKKKC VLASSLPSEE RFTEVLTNDF FPTLMLYLHI
RDESTVTLRV AIALSIVQLV ALLPEEEIVL RLTPVLIDTC HILRSRSLES RDATRKALAA
ISKFLGPKYF SFIISQLQTS LKRGYQLHVL GYTVHYLLLA IEDVYPYGSI DYCMDSLAQI
FVDEIFGEVG VEKDSEDYKS NVKEIKGNKS YDSYEIVARI SSFDSLSTLL RPVKNVLFET
NVPKSLRKVD ELCRRLSLGI VANKQSASQS SLIFCYNVYE FVVKEKETVA ALKQQENDGY
RSAPNFFLEN SKKLIRFTFD VLRGVSNKHK ELLTARNMAA FVPLIGESLL SSSEEVQISA
LRFLVLLLPL KIDQVFSGSS VFTSQAVKYI QNSPSTNTEL CQASFKFLAS ILPYENVKIK
ESTINYLLER VGTDIQEPDR QGVMFSLVRA VIARKIMTPE LYKIIDLIRD MMVTNHTKST
RQTCRHLYYS FLLDYPQGKT RLSKQISFIL KNLEYEFAPG RESVMELLHL ILNNFSDALL
KEYHQGIFIA LVMVLANDSE PHCREMSAEL IKLVYQRADN ENFNLIRQLL SHWTSVEKAG
KNLVRVSMQL FGLLFETFGF ERMEEVHLFT KVFERVLSTT ISHPEEATNE WELNYFGLQS
WLKLVLADPK KSCEKEFSKI WESMRYLILF KHAWVRLSVS RLFGHFFAII GDSNFGKLSL
GIDGVVFSLD FVTQISNALQ AQLRSPVLSE ELGMQVAKNL IFLTRWFNSI RSSDDSPFLE
IFRRMRKTLK KQTIEEYSIN KKYLMQWFAS VIHVFSGEEL QPVLSEIIAA LYRYTELQEA
ERKSQQELAD LVTESLQVLQ EKVGATVFAR AYQEVRNAAI EVRRERREKR AIEQVVAPEV
ASRKKIRKNE RKRENRKQKT NHHRMVNSIF KNR