ID   UTP21_SCHPO             Reviewed;         902 AA.
AC   O14053;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 146.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 21 homolog;
DE            Short=U3 snoRNA-associated protein 21;
GN   ORFNames=SPCC1672.07;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA and
CC       ribosome assembly. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with snoRNA U3. Interacts with MPP10. Component of
CC       the ribosomal small subunit (SSU) processome composed of at least 40
CC       protein subunits and snoRNA U3 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The WD repeats are grouped into two tandem seven-bladed beta-
CC       propeller regions. {ECO:0000250}.
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DR   EMBL; CU329672; CAA20445.1; -; Genomic_DNA.
DR   PIR; T41051; T41051.
DR   RefSeq; NP_587878.1; NM_001022870.2.
DR   AlphaFoldDB; O14053; -.
DR   SMR; O14053; -.
DR   BioGRID; 275867; 11.
DR   IntAct; O14053; 1.
DR   STRING; 4896.SPCC1672.07.1; -.
DR   iPTMnet; O14053; -.
DR   MaxQB; O14053; -.
DR   PaxDb; O14053; -.
DR   EnsemblFungi; SPCC1672.07.1; SPCC1672.07.1:pep; SPCC1672.07.
DR   GeneID; 2539299; -.
DR   KEGG; spo:SPCC1672.07; -.
DR   PomBase; SPCC1672.07; -.
DR   VEuPathDB; FungiDB:SPCC1672.07; -.
DR   eggNOG; KOG1539; Eukaryota.
DR   HOGENOM; CLU_002774_2_0_1; -.
DR   InParanoid; O14053; -.
DR   OMA; KFVGHTA; -.
DR   PhylomeDB; O14053; -.
DR   Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:O14053; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0032153; C:cell division site; HDA:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0072686; C:mitotic spindle; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0034388; C:Pwp2p-containing subcomplex of 90S preribosome; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; ISO:PomBase.
DR   GO; GO:0006364; P:rRNA processing; ISO:PomBase.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR007319; SSU_processome_Utp21.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF04192; Utp21; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 11.
DR   SUPFAM; SSF50978; SSF50978; 2.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; WD repeat.
FT   CHAIN           1..902
FT                   /note="U3 small nucleolar RNA-associated protein 21
FT                   homolog"
FT                   /id="PRO_0000051496"
FT   REPEAT          40..71
FT                   /note="WD 1"
FT   REPEAT          80..110
FT                   /note="WD 2"
FT   REPEAT          119..154
FT                   /note="WD 3"
FT   REPEAT          164..198
FT                   /note="WD 4"
FT   REPEAT          206..243
FT                   /note="WD 5"
FT   REPEAT          249..284
FT                   /note="WD 6"
FT   REPEAT          289..332
FT                   /note="WD 7"
FT   REPEAT          339..373
FT                   /note="WD 8"
FT   REPEAT          399..438
FT                   /note="WD 9"
FT   REPEAT          447..481
FT                   /note="WD 10"
FT   REPEAT          492..528
FT                   /note="WD 11"
FT   REPEAT          533..568
FT                   /note="WD 12"
FT   REPEAT          570..611
FT                   /note="WD 13"
FT   REPEAT          613..651
FT                   /note="WD 14"
SQ   SEQUENCE   902 AA;  100570 MW;  5EEFFC6034BDC047 CRC64;
     MPFAEKKRRT YENAVKPLRK SRIYAPFRSI GHVSNAVPFD IEARGTHFLV TTSVGNTFQT
     YDCEKLNLLF VGKQLDKEIT CLKSFKDFML VAAGSKIFAY KRGKIIWDID VEQEHGTVTH
     LDAFGEWIIA CTSSRHVYVW KHASKYSVPE LHTTFLPNTN ADITSLLHPS TYLNKILLGF
     SDGALQIWNL RVSKRVHEFQ EFFGDGITSL TQAPVLDVLA VGTISGRIVI FNLKNGSILM
     EFKQDGQVLS CSFRTDGTPI LASSNPIGDL SFWDLSKRRI QNVTYNAHFG SLPKIQFLNG
     QPILVTAGPD NSLKEWIFDS MDGAPRILRS RNGHYEPPSF VKFYGKSVHF LISAATDRSL
     RAVSLYQDSQ STELSQGSVI SKAKKLNVRP EELKLPEITA LSSSNTREKY WDNVLTAHKN
     DSSARTWNWK SKTLGQHVLP TSDGTSVRSV CVSCCGNFGL IGSSKGVVDV YNMQSGIKRK
     SFGQSSLSGK PVTAVMLDNV NRILVTASLD GILKFWDFNK GNLIDSLDVG SSITHAIYQH
     SSDLVAVACD DFGIRIVDVQ TRKIVRELWG HSNRLTSFDF SDTGRWLVTA SLDGTIRTWD
     LPTGHLIDSI STPSVCTSLT FAPTGDYLAT THVDQVGISL WTNLSMFKHV STKALRLDDV
     VEVSAPSVSG EKGISVVEAA LNVESNAEDE EDISYRTMDQ LDPNLQTLSK LPRTQWQTLI
     NLEAIKARNA PKEVPKVPEK APFFLPSLKD QSEATVPKQP IATEISKPTA VASIKVSGTE
     FSTLLHGNDD DAFFEYLKSL GPAKIDLEIR SLDAYPPYEE FILFINIMTR RLSKRRDFEL
     VQACMSVFTK SHEDVLLMHD TPEDTVPVFE SLKAWESVHK EENQRLLDLV GYCSGILSFM
     RT