ID   UTP22_SCHPO             Reviewed;        1097 AA.
AC   O94676;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 22;
DE            Short=U3 snoRNA-associated protein 22;
GN   Name=utp22 {ECO:0000250|UniProtKB:P53254}; ORFNames=SPBC776.08c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1] {ECO:0000312|EMBL:CAA22881.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2] {ECO:0000305}
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA and
CC       ribosome assembly. {ECO:0000250|UniProtKB:P53254}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC       {ECO:0000250|UniProtKB:P53254}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the NRAP family. {ECO:0000255}.
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DR   EMBL; CU329671; CAA22881.1; -; Genomic_DNA.
DR   PIR; T40678; T40678.
DR   RefSeq; NP_596323.1; NM_001022245.2.
DR   AlphaFoldDB; O94676; -.
DR   SMR; O94676; -.
DR   BioGRID; 277690; 8.
DR   STRING; 4896.SPBC776.08c.1; -.
DR   iPTMnet; O94676; -.
DR   MaxQB; O94676; -.
DR   PaxDb; O94676; -.
DR   PRIDE; O94676; -.
DR   EnsemblFungi; SPBC776.08c.1; SPBC776.08c.1:pep; SPBC776.08c.
DR   GeneID; 2541176; -.
DR   KEGG; spo:SPBC776.08c; -.
DR   PomBase; SPBC776.08c; utp22.
DR   VEuPathDB; FungiDB:SPBC776.08c; -.
DR   eggNOG; KOG2054; Eukaryota.
DR   HOGENOM; CLU_003502_1_0_1; -.
DR   InParanoid; O94676; -.
DR   OMA; PTIRLVK; -.
DR   PhylomeDB; O94676; -.
DR   Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:O94676; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0032545; C:CURI complex; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0032040; C:small-subunit processome; ISO:PomBase.
DR   GO; GO:0034456; C:UTP-C complex; ISO:PomBase.
DR   GO; GO:0030515; F:snoRNA binding; ISO:PomBase.
DR   GO; GO:0030490; P:maturation of SSU-rRNA; ISO:PomBase.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   GO; GO:0006409; P:tRNA export from nucleus; IBA:GO_Central.
DR   InterPro; IPR005554; NOL6/Upt22.
DR   InterPro; IPR035082; Nrap_D1.
DR   InterPro; IPR035367; Nrap_D2.
DR   InterPro; IPR035368; Nrap_D3.
DR   InterPro; IPR035369; Nrap_D4.
DR   InterPro; IPR035370; Nrap_D5.
DR   InterPro; IPR035371; Nrap_D6.
DR   PANTHER; PTHR17972; PTHR17972; 1.
DR   Pfam; PF03813; Nrap; 1.
DR   Pfam; PF17403; Nrap_D2; 1.
DR   Pfam; PF17404; Nrap_D3; 1.
DR   Pfam; PF17405; Nrap_D4; 1.
DR   Pfam; PF17406; Nrap_D5; 1.
DR   Pfam; PF17407; Nrap_D6; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN           1..1097
FT                   /note="U3 small nucleolar RNA-associated protein 22"
FT                   /id="PRO_0000317218"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1097 AA;  126081 MW;  1D8556B26FF51282 CRC64;
     MNGLKREHES SSSQDGSKTP ETEYDSHVDS IEDIHSLASK RKKLNEKKEN LEDLTLLKTS
     AFELKLNELI REISVRGKYF RHANTFVEKI KDLIFKTPVI PETNFWSACK NLEKDKKVIV
     PLAEPLSAKD TNLRASFVPP KTVTPGIFSC SNKFFLNPDG WSYDLFLEIP ESIFTQKDYL
     NGRYFRKRAF YLTCIAKHLL ENLGNEVKLE FVAFNDDIRR PILAILPESK GFAATGKRFT
     VFLIPTVRQI FPVSKLLPHK NAIRDFMEHE ELKPTPFYNN SVLEEQNLLF YRDLVKKYSV
     NPQFLDACGL GSTWLNMRGF SSSIHSNGFG LLEWYVLMAL LMSSTGLPAG NVLNTYLTAA
     QFFKSMLQFL SSKNLTSTLF KLNADSSNLK IGNGHLPTLI DCNTGFNLLG KMKQSFFEYF
     QASCRHTLNL LDENANYNFS KIFITHVNVP ALEFDVSGCI PLEPKELEDP NFCRKTDLDS
     PYSLYLEYTW DLLQHALGDR VCQIILYSSI CTSCSINESL KTKLPKLISF GLLLNPDALL
     RLVDIGPSPD DTVGSQKFRE FWGEVSELRK FKNGSIAESV YWECSSPDER IRIPQRIIRH
     ILNRHLGNNV GDRVSFRNEK FRVYVHSKIS PNTDTYNEYV PVMEAYNEAV KSLINLSDIP
     LSIAEILPAD ESLRYSSSSV PFYESSTCAP IDVVFQFESS SKWPDELEGI QRTKIAFLLK
     IAELLEALDN VERASVGLEN TDNPTHNCCF LQVLFSNNFT FRYRLRNDRE IFFWKSLERN
     PSTKLSAQKG LYAYEHMFQF IPRHTLAIQA ICQAHRSYSM AVRLAKHWFY SHLLTDHVTD
     EVIELLVASV YINSSSWRTT SSGETSFCRM LHFLAHWDWR FDPLIINSNG KLPHDVRHQA
     TEKLESIRKQ DVAIAHNAYY IITDYDFDGN HIGYYKPSKI IANRITSLAR ASLSELLKDT
     PNYKSIFKSS LDIYHVVIDV NINKLPMYRE SNLTKYKNLQ NMSSERPGFE PITEFVKELH
     RCFEDTISFF YNKKNPKVVT GVFNPRILAN RPYRTNIDYP FKVVDKDTVV LDADVVCEEI
     RQVGGDLIRS IQLQLKA