UTP23_HUMAN
ID UTP23_HUMAN Reviewed; 249 AA.
AC Q9BRU9; B2RE25; Q96NJ8;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=rRNA-processing protein UTP23 homolog;
GN Name=UTP23; Synonyms=C8orf53;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-174, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [6]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-179, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: Involved in rRNA-processing and ribosome biogenesis.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q9BRU9; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-5457544, EBI-3867333;
CC Q9BRU9; Q08379: GOLGA2; NbExp=3; IntAct=EBI-5457544, EBI-618309;
CC Q9BRU9; P28799: GRN; NbExp=3; IntAct=EBI-5457544, EBI-747754;
CC Q9BRU9; Q15323: KRT31; NbExp=3; IntAct=EBI-5457544, EBI-948001;
CC Q9BRU9; O76011: KRT34; NbExp=3; IntAct=EBI-5457544, EBI-1047093;
CC Q9BRU9; O76015: KRT38; NbExp=3; IntAct=EBI-5457544, EBI-1047263;
CC Q9BRU9; Q6A162: KRT40; NbExp=3; IntAct=EBI-5457544, EBI-10171697;
CC Q9BRU9; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-5457544, EBI-11749135;
CC Q9BRU9; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-5457544, EBI-10172150;
CC Q9BRU9; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-5457544, EBI-10171774;
CC Q9BRU9; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-5457544, EBI-10172052;
CC Q9BRU9; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-5457544, EBI-11953334;
CC Q9BRU9; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-5457544, EBI-16439278;
CC Q9BRU9; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-5457544, EBI-10172526;
CC Q9BRU9; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-5457544, EBI-10271199;
CC Q9BRU9; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-5457544, EBI-945833;
CC Q9BRU9; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-5457544, EBI-22310682;
CC Q9BRU9; O76083: PDE9A; NbExp=3; IntAct=EBI-5457544, EBI-742764;
CC Q9BRU9; P15884: TCF4; NbExp=3; IntAct=EBI-5457544, EBI-533224;
CC Q9BRU9; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-5457544, EBI-11139477;
CC Q9BRU9; Q12933: TRAF2; NbExp=3; IntAct=EBI-5457544, EBI-355744;
CC Q9BRU9; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-5457544, EBI-492476;
CC Q9BRU9; P36406: TRIM23; NbExp=3; IntAct=EBI-5457544, EBI-740098;
CC Q9BRU9; P14373: TRIM27; NbExp=3; IntAct=EBI-5457544, EBI-719493;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BRU9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BRU9-2; Sequence=VSP_024874, VSP_024875;
CC -!- SIMILARITY: Belongs to the UTP23/FCF1 family. UTP23 subfamily.
CC {ECO:0000305}.
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DR EMBL; AK055279; BAB70896.1; -; mRNA.
DR EMBL; AK315770; BAG38122.1; -; mRNA.
DR EMBL; AC087350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP002905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471060; EAW91960.1; -; Genomic_DNA.
DR EMBL; BC005955; AAH05955.1; -; mRNA.
DR EMBL; BC022441; AAH22441.1; -; mRNA.
DR CCDS; CCDS6320.1; -. [Q9BRU9-1]
DR RefSeq; NP_115710.2; NM_032334.2. [Q9BRU9-1]
DR AlphaFoldDB; Q9BRU9; -.
DR SMR; Q9BRU9; -.
DR BioGRID; 124021; 345.
DR IntAct; Q9BRU9; 49.
DR STRING; 9606.ENSP00000308332; -.
DR GlyGen; Q9BRU9; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9BRU9; -.
DR PhosphoSitePlus; Q9BRU9; -.
DR BioMuta; UTP23; -.
DR DMDM; 296452859; -.
DR EPD; Q9BRU9; -.
DR jPOST; Q9BRU9; -.
DR MassIVE; Q9BRU9; -.
DR MaxQB; Q9BRU9; -.
DR PaxDb; Q9BRU9; -.
DR PeptideAtlas; Q9BRU9; -.
DR PRIDE; Q9BRU9; -.
DR ProteomicsDB; 78838; -. [Q9BRU9-1]
DR ProteomicsDB; 78839; -. [Q9BRU9-2]
DR Antibodypedia; 42960; 81 antibodies from 17 providers.
DR DNASU; 84294; -.
DR Ensembl; ENST00000309822.7; ENSP00000308332.2; ENSG00000147679.12. [Q9BRU9-1]
DR GeneID; 84294; -.
DR KEGG; hsa:84294; -.
DR MANE-Select; ENST00000309822.7; ENSP00000308332.2; NM_032334.3; NP_115710.2.
DR UCSC; uc003yoc.4; human. [Q9BRU9-1]
DR CTD; 84294; -.
DR DisGeNET; 84294; -.
DR GeneCards; UTP23; -.
DR HGNC; HGNC:28224; UTP23.
DR HPA; ENSG00000147679; Low tissue specificity.
DR neXtProt; NX_Q9BRU9; -.
DR OpenTargets; ENSG00000147679; -.
DR PharmGKB; PA162408778; -.
DR VEuPathDB; HostDB:ENSG00000147679; -.
DR eggNOG; KOG3164; Eukaryota.
DR GeneTree; ENSGT00940000153117; -.
DR HOGENOM; CLU_053567_3_0_1; -.
DR InParanoid; Q9BRU9; -.
DR OMA; ASKKWVQ; -.
DR OrthoDB; 1364586at2759; -.
DR PhylomeDB; Q9BRU9; -.
DR TreeFam; TF105804; -.
DR PathwayCommons; Q9BRU9; -.
DR SignaLink; Q9BRU9; -.
DR BioGRID-ORCS; 84294; 494 hits in 1084 CRISPR screens.
DR ChiTaRS; UTP23; human.
DR GenomeRNAi; 84294; -.
DR Pharos; Q9BRU9; Tbio.
DR PRO; PR:Q9BRU9; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q9BRU9; protein.
DR Bgee; ENSG00000147679; Expressed in kidney epithelium and 189 other tissues.
DR ExpressionAtlas; Q9BRU9; baseline and differential.
DR Genevisible; Q9BRU9; HS.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IDA:CAFA.
DR GO; GO:0048027; F:mRNA 5'-UTR binding; IDA:CAFA.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0070181; F:small ribosomal subunit rRNA binding; IBA:GO_Central.
DR GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:Ensembl.
DR InterPro; IPR006984; Fcf1/Utp23.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR Pfam; PF04900; Fcf1; 1.
DR SUPFAM; SSF88723; SSF88723; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Isopeptide bond; Nucleus; Phosphoprotein;
KW Reference proteome; Ribosome biogenesis; rRNA processing; Ubl conjugation.
FT CHAIN 1..249
FT /note="rRNA-processing protein UTP23 homolog"
FT /id="PRO_0000285634"
FT REGION 180..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 174
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT CROSSLNK 179
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 122..145
FT /note="DQNLSVKVKKKPGVPLMFIIQNTM -> YIPRMYTFCTNYGGQQYVIDALIG
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_024874"
FT VAR_SEQ 146..249
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_024875"
FT VARIANT 170
FT /note="H -> R (in dbSNP:rs16888722)"
FT /id="VAR_032031"
FT VARIANT 195
FT /note="K -> Q (in dbSNP:rs1133950)"
FT /id="VAR_032032"
FT VARIANT 215
FT /note="P -> L (in dbSNP:rs16888728)"
FT /id="VAR_032033"
FT CONFLICT 225
FT /note="K -> R (in Ref. 4; AAH05955/AAH22441)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 249 AA; 28402 MW; 5DBFD9D7D64D96EE CRC64;
MKITRQKHAK KHLGFFRNNF GVREPYQILL DGTFCQAALR GRIQLREQLP RYLMGETQLC
TTRCVLKELE TLGKDLYGAK LIAQKCQVRN CPHFKNAVSG SECLLSMVEE GNPHHYFVAT
QDQNLSVKVK KKPGVPLMFI IQNTMVLDKP SPKTIAFVKA VESGQLVSVH EKESIKHLKE
EQGLVKNTEQ SRRKKRKKIS GPNPLSCLKK KKKAPDTQSS ASEKKRKRKR IRNRSNPKVL
SEKQNAEGE
