UTP23_MOUSE
ID UTP23_MOUSE Reviewed; 249 AA.
AC Q9CX11; Q8BY14;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=rRNA-processing protein UTP23 homolog;
GN Name=Utp23;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Stomach, Testis, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in rRNA-processing and ribosome biogenesis.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the UTP23/FCF1 family. UTP23 subfamily.
CC {ECO:0000305}.
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DR EMBL; AK021306; BAB32368.1; -; mRNA.
DR EMBL; AK042518; BAC31281.1; -; mRNA.
DR EMBL; AK134445; BAE22147.1; -; mRNA.
DR EMBL; BC046791; AAH46791.1; -; mRNA.
DR EMBL; BC056961; AAH56961.1; -; mRNA.
DR CCDS; CCDS27462.1; -.
DR RefSeq; NP_084408.1; NM_030132.5.
DR AlphaFoldDB; Q9CX11; -.
DR SMR; Q9CX11; -.
DR BioGRID; 219498; 1.
DR STRING; 10090.ENSMUSP00000119261; -.
DR PhosphoSitePlus; Q9CX11; -.
DR EPD; Q9CX11; -.
DR MaxQB; Q9CX11; -.
DR PaxDb; Q9CX11; -.
DR PeptideAtlas; Q9CX11; -.
DR PRIDE; Q9CX11; -.
DR ProteomicsDB; 300205; -.
DR Antibodypedia; 42960; 81 antibodies from 17 providers.
DR Ensembl; ENSMUST00000137116; ENSMUSP00000119261; ENSMUSG00000022313.
DR GeneID; 78581; -.
DR KEGG; mmu:78581; -.
DR UCSC; uc007vrc.2; mouse.
DR CTD; 84294; -.
DR MGI; MGI:1925831; Utp23.
DR VEuPathDB; HostDB:ENSMUSG00000022313; -.
DR eggNOG; KOG3164; Eukaryota.
DR GeneTree; ENSGT00940000153117; -.
DR HOGENOM; CLU_053567_3_0_1; -.
DR InParanoid; Q9CX11; -.
DR OMA; ASKKWVQ; -.
DR OrthoDB; 1364586at2759; -.
DR PhylomeDB; Q9CX11; -.
DR TreeFam; TF105804; -.
DR BioGRID-ORCS; 78581; 25 hits in 71 CRISPR screens.
DR ChiTaRS; Utp23; mouse.
DR PRO; PR:Q9CX11; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q9CX11; protein.
DR Bgee; ENSMUSG00000022313; Expressed in cleaving embryo and 228 other tissues.
DR ExpressionAtlas; Q9CX11; baseline and differential.
DR Genevisible; Q9CX11; MM.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; ISO:MGI.
DR GO; GO:0048027; F:mRNA 5'-UTR binding; ISO:MGI.
DR GO; GO:0070181; F:small ribosomal subunit rRNA binding; IBA:GO_Central.
DR GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:MGI.
DR InterPro; IPR006984; Fcf1/Utp23.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR Pfam; PF04900; Fcf1; 1.
DR SUPFAM; SSF88723; SSF88723; 1.
PE 2: Evidence at transcript level;
KW Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome;
KW Ribosome biogenesis; rRNA processing; Ubl conjugation.
FT CHAIN 1..249
FT /note="rRNA-processing protein UTP23 homolog"
FT /id="PRO_0000285635"
FT REGION 180..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 174
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BRU9"
FT CROSSLNK 179
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9BRU9"
FT CONFLICT 50
FT /note="P -> H (in Ref. 1; BAC31281)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 249 AA; 28380 MW; D1BC8A1CD1EDC8C4 CRC64;
MKITRQKHAK KHLGFFRNNF GVREPYQILL DGTFCQAALR GRIQLRDQLP RYLMGETQLC
TTRCVLKELE TLGKELYGAK LIAQKCQVRN CPHFKSPVSG SECLLSMVDE GNPHHYFVAT
QDQNLSVKVK RTPGIPLMFI IQNTIVLDKP SPRTVAFVKA VEAGQLVSVH EKQSIKQLKE
EQGLVRNPDL RRRRRKKKKV GGPNPLSCLK KKKKAQDTKS PASEKKRKRK RIRNRSTLKV
SSEQQGAEG
