ID   UTP23_SCHPO             Reviewed;         260 AA.
AC   O74862;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=rRNA-processing protein utp23;
DE   AltName: Full=U three protein 23;
GN   Name=utp23; ORFNames=SPCC18.12c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Involved in rRNA-processing and ribosome biogenesis.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the UTP23/FCF1 family. UTP23 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CU329672; CAA21426.1; -; Genomic_DNA.
DR   PIR; T41155; T41155.
DR   RefSeq; NP_588391.1; NM_001023382.2.
DR   AlphaFoldDB; O74862; -.
DR   SMR; O74862; -.
DR   BioGRID; 275730; 5.
DR   STRING; 4896.SPCC18.12c.1; -.
DR   iPTMnet; O74862; -.
DR   MaxQB; O74862; -.
DR   PaxDb; O74862; -.
DR   PRIDE; O74862; -.
DR   EnsemblFungi; SPCC18.12c.1; SPCC18.12c.1:pep; SPCC18.12c.
DR   GeneID; 2539158; -.
DR   KEGG; spo:SPCC18.12c; -.
DR   PomBase; SPCC18.12c; utp23.
DR   VEuPathDB; FungiDB:SPCC18.12c; -.
DR   eggNOG; KOG3164; Eukaryota.
DR   HOGENOM; CLU_053567_1_1_1; -.
DR   InParanoid; O74862; -.
DR   OMA; ASKKWVQ; -.
DR   PhylomeDB; O74862; -.
DR   PRO; PR:O74862; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR   GO; GO:0032040; C:small-subunit processome; ISO:PomBase.
DR   GO; GO:0004540; F:ribonuclease activity; IEA:UniProt.
DR   GO; GO:0070181; F:small ribosomal subunit rRNA binding; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; ISO:PomBase.
DR   InterPro; IPR006984; Fcf1/Utp23.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR002716; PIN_dom.
DR   Pfam; PF04900; Fcf1; 1.
DR   SMART; SM00670; PINc; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..260
FT                   /note="rRNA-processing protein utp23"
FT                   /id="PRO_0000339874"
FT   DOMAIN          26..129
FT                   /note="PINc"
FT   REGION          188..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        188..213
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   260 AA;  29638 MW;  C1CB26131B150B98 CRC64;
     MRQKRAKNYR KLMHTYQLLF GFREPYQVLV DADFLKDLSQ QKIDIQAALA RTVQGAIKPM
     ITQCCIRQLY SKSDELKQEI RIAKSFERRR CGHIDEALSP SECIQSVVNI NGRNKHRYVV
     ATQDPELRQA LRSVPGVPLI YMKRSVVILE PASRATLLEK HNKESVQMGM SKEEKLLLSG
     KKRSANELAI DDQDTKESTD LAGTEDSAPK ANKKRKGPKG PNPLSIKKRS SKNHTTDEPT
     LPVNIIGDVG ERKKHRRKRK