ID   UTP25_AJECG             Reviewed;         716 AA.
AC   C0NQU6;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=HCBG_05376;
OS   Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS   (Darling's disease fungus) (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=447093;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432;
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA   Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA   Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA   San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; GG663369; EEH06060.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0NQU6; -.
DR   STRING; 447093.C0NQU6; -.
DR   EnsemblFungi; EEH06060; EEH06060; HCBG_05376.
DR   VEuPathDB; FungiDB:HCBG_05376; -.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; C0NQU6; -.
DR   OrthoDB; 257318at2759; -.
DR   Proteomes; UP000001631; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..716
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408092"
FT   REGION          1..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..71
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        96..112
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   716 AA;  80685 MW;  E6B63AC4A45F9E66 CRC64;
     MAAPRGKGSR SSNSRGTRGA RGKRQRGGRP AFETSRVEKN NDDGSSGSDA EAESPPIDEL
     SSDSDDDYDA DGEEKKMDKP YNTLLQLFNT SQDTNGPARK RRKVDHNSKK TEIQVEEQDE
     LHDEADLSEP EITDDDEIED LADVAAEEVE AGDSGDENDN SSSLSLNIKA ISSKGWLSHK
     SELPGRFRLM FSHPDTGGDT VQLPAPIHGL QSLKLKQKLA LHAGDHITKF DSLASGLAPS
     IFGYHDLLFG ARTLSNSARF RDLYCLHVLN HILKTRDRVL KNNSRSQKVP DQDLELRDQG
     FTRPKVLIIL PTRQACVRVM ESITKLYHAE QQENKTKFYD TFSAADDKSW ENKPDDFREL
     FGGNDDDMFR LGLKFTRKTI KYFSHFYNSD MILASPLGLR MVMDKEDSKK QDFDFLSSIE
     VAIIDQADAL LMQNWEHVEY VFSHLNLQPK ESHGCDFSRV RNWYLDGQAK YVRQTLVFSS
     FITPEINALF SSQMQNTAGK LKITPTYAGA ILDLPLPVPV KQTFSRFDST SPVNDPENRF
     KYFTNAVLSP LVRSSTGGRG NPSASGTLIF IPSYLDFVRV RNYLATSSQT ENLSFGAISE
     YTSVRDVARA RTHFFSGRHS ALLYTERTHH FRRYQIRGVK RVIMYGVPEN PVFWAEIVGF
     LGLDPAGAAE AAEGGVRALF SKWDALKMER IVGTKSRMPR RNTFWSHQPP SFLLLE