ID   UTP25_AJECH             Reviewed;         711 AA.
AC   C6HQ17;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 2.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=HCDG_08298;
OS   Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=544712;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H143;
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA   Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA   Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA   Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA   Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain H143.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EER37628.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; GG692434; EER37628.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; C6HQ17; -.
DR   STRING; 544712.C6HQ17; -.
DR   EnsemblFungi; EER37628; EER37628; HCDG_08298.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   Proteomes; UP000002624; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..711
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408093"
FT   REGION          1..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..116
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..137
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   711 AA;  79829 MW;  55213E71BB80A65F CRC64;
     MAAPRGKGSR SSNSRGTRGA RGKRQRGGRP AFETSRVEKI NDDGLSGSDA EAESPPIDEL
     SSDSDDYDAD GEEKKIEKPY NTLLQLFNTS QDTNGPARKR RKVDHNSKKT EIQVEEQDEL
     HDEADLSEPE ITDDDEIEDP ADVAAEEVEA GDSGDENDNS SSLSLNIKAI SSKGWLSHKS
     ELPGRFRLMF SHPDTGGDTV QLPAPIHGLQ SLKLKQKLAL HAGDHITKFD SLASGLAPSI
     FGYHDLLFGA RTLSNSARFR DLYCLHVLNH ILKTRDRVLK NNSRSQKVPD QDLELRDQGF
     TRPKVLIILP TRQACVRVME SITKLYHAEQ QENKTKFYDT FSAADDKSWE NKPDDFRELF
     GGNDDDMFRL GLKFTRKTIK YFSHFYNSDM ILASPLGLRM VMDKEDSKKQ DFDFLSSIEV
     AIVDQADALL MQNWEHVEYV FSHLNLQPKE SHGCDFSRVR NWYLDGQAKY VRQTLVFSSF
     ITPEINALFS SQMQNTAGKL KITPTYAGAI LDLPLPVPVK QTFSRFDSTS PVNDPENRFK
     YFTNAVLSPL VRSSAGGRGN PSASGTLIFI PSYLDFVRVR NYLATSSQTE NLSFGAISEY
     TSVRDVARAR THFFSGRHSA LLYTERTHHF RRYQIRGVKR VIMYGVPENP VFWAEIVGFL
     GLDPAGAAEA AEGGVRALFS KWDALKMERI VGTKRLGNML IEKGGDTFTF V