ID   UTP25_AJEDR             Reviewed;         680 AA.
AC   C5GAH0;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=BDCG_02009;
OS   Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces
OS   dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX   NCBI_TaxID=559297;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ER-3 / ATCC MYA-2586;
RX   PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA   Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA   Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA   Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA   Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA   Clay O.K., Klein B.S., Cuomo C.A.;
RT   "The dynamic genome and transcriptome of the human fungal pathogen
RT   Blastomyces and close relative Emmonsia.";
RL   PLoS Genet. 11:E1005493-E1005493(2015).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; EQ999974; EEQ86889.1; -; Genomic_DNA.
DR   AlphaFoldDB; C5GAH0; -.
DR   STRING; 559297.C5GAH0; -.
DR   EnsemblFungi; EEQ86889; EEQ86889; BDCG_02009.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   Proteomes; UP000002039; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..680
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408094"
FT   REGION          1..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..73
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..116
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   680 AA;  76782 MW;  E2BA9FD44677F8A1 CRC64;
     MVAPRGRDAE DEVELIDELS SGSDDDDEED KKTSKPYNTL LQLFNAGQDT NGPARKRRKV
     EHSSKKTEVQ IKEPEELDDE ADLSESEIED DEEDEDAEGI AVDEGEAEDS GDEDDATDPF
     ETHFSNVDSS LLLQQINVIS TKGWKTHKNE LPGKFRLVLS HPDTGGDAVQ LPPPAHGLQS
     LKLKQKLANH AGDHIAKFES LTSGLVPYIF GYQDLLFGAR TLSNSAKFRD LYCLHVLNHI
     LKTRDRVLKN NSRSQKEPDQ DLELRDQGFT RPKVLIILPT RQACVRVVES ITKLYHAEQQ
     ENKSRFYDTF SAADDKSWED KPDDFRELFG GNDDDMFRLG LKFTRKTIKY FSQFYNSDII
     LASPLGLRMV MDKEDGKKQD FDFLSSIEVA VVDQADALLM QNWEHIEYVF SHLNLQPKES
     HGCDFSRVRN WYLDGQAKYV RQTLVFSSFI TPEINALFSS QMHNTAGKVK VTPTYEGAIL
     DIPLPVPVKQ TFSRFNSTSP VKDPDDRFKY FTSAVLSSLV RSSTGSGGKP HASGTLIFIP
     SYLDFVRVRN YLATSSQTEN LSFGAISEYT SVRDVARART HFFSGRHSAL LYTERTHHFR
     RYQIRGVKRV IMYGVPENPV FWGEIVGFLG LDPAGTAEAA EGGVRALFSK WDALKMERIV
     GTKRLGNMLM EKGGDTFSFV