ID   UTP25_ARTGP             Reviewed;         713 AA.
AC   E4V6L3;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=MGYG_08654;
OS   Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS   gypseum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX   NCBI_TaxID=535722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4604 / CBS 118893;
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; DS989831; EFQ96729.1; -; Genomic_DNA.
DR   RefSeq; XP_003169106.1; XM_003169058.1.
DR   AlphaFoldDB; E4V6L3; -.
DR   STRING; 63402.XP_003169106.1; -.
DR   PRIDE; E4V6L3; -.
DR   EnsemblFungi; EFQ96729; EFQ96729; MGYG_08654.
DR   GeneID; 10024388; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; E4V6L3; -.
DR   OMA; KYFRQTI; -.
DR   OrthoDB; 257318at2759; -.
DR   Proteomes; UP000002669; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..713
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408097"
FT   REGION          1..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..47
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..65
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..108
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        128..145
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   713 AA;  80379 MW;  9E5E55EBD63D5AB3 CRC64;
     MAVHHKRAGS HRGRGSKAGR SRGRKFETSR LKDVSQDESS GKEENEHVEP EEEMDDSEAS
     DVSSESDLDE PPKENSYSTL LKLLNSNAKS SEPARKKRKI KADEQDTTQV EVSMRTTEDV
     KQVDEVADTE ASEDENMDNE GLHEEDDADG IGSDGNHDMF EIHFGNPDET ELSKRIESCS
     RQWKSTKADL IDGLYSVASK PDVGDSLSTS LPTTPSPADL KLKQNLAKAA VSFDGLNSCL
     TPYIFGYYDT LFCSRTTHNS AKLRDLYCLH ALNHVLKTRD RVIKNSAILS REDSGDIELR
     DQGFTRPKVL IILPTRQACV RVVDSLTKLY PMEQQENKKR FMDSFSAADS DDWGHKPDDF
     KELFGGNDDD MFRLGLKFTR KSLKFFSQFY SSDIIISSPL GLRTAIEKEG GKKLGNDFLS
     SIEMVIVDHA DALIMQNWDH VEYIFSNLNL QPKEAHGCDF SRVRQWYLDG HGKFVRQTLV
     FSAFNTPELN ALYNTQMQNV FGKAKIMPKY EGAMLNLRLP VSIKQTFSRF DSASPLKDPE
     ARFQYFTRTV LASLARGWIE SSSGKGKSGG TLIFIPSYLD FVRVRNHFAN SSQTENISFG
     LISEYTSVRD SSRARSHFMN GRHSVLLYTE RAHHFRRYNI RGVTNVVMYG LPDNPIFWGD
     LVEYLGSAAS GAVTPTLRVL FSKWDALKLE RVVGTARVRS MLLEKGGDTF TFV