ID   UTP25_ARTOC             Reviewed;         714 AA.
AC   C5G0N1;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=MCYG_08503;
OS   Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX   NCBI_TaxID=554155;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4605 / CBS 113480;
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; DS995709; EEQ35684.1; -; Genomic_DNA.
DR   RefSeq; XP_002842672.1; XM_002842626.1.
DR   AlphaFoldDB; C5G0N1; -.
DR   STRING; 63405.XP_002842672.1; -.
DR   EnsemblFungi; EEQ35684; EEQ35684; MCYG_08503.
DR   GeneID; 9224105; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   OMA; KYFRQTI; -.
DR   OrthoDB; 257318at2759; -.
DR   Proteomes; UP000002035; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..714
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408098"
FT   REGION          1..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..52
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..86
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..105
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   714 AA;  80520 MW;  CABBB8DA73240E7C CRC64;
     MAVHHKRAGA HRGRGSKPGR GRGRKFETSR LKDVSEDNSS GDEERANVEP VEEPGDSEGS
     VVSSGSDLDD QPRENSYSTL LKLLNNDAKS NEPARKKRKI RPNEQHTSLS ELPIPVEGDV
     DPGNELVDME ESEDEIIDDA DSHLEDDIDG LVTDGRNDPF ESHFGNPDES ELSQKIEACS
     RRWRSIKSDL IDGLYAVACS PDVEQATSVV LPTTPTPVDL KLKRKLARSA ISFDPLSTCL
     TPYIFGYRDT FFCSRTTQNS AKLRDIYCLH ALNHVLKTRD RVIKNSAILS KEDGGDIELR
     DQGFTRPKVL IILPTRQACV RLVDSLTKLF PMEQQENKKR FMDSFSAADN DGWVNKTDDF
     KELFGGNDDD MFRLGLKFTR KSLKLFSQFY SSDIIIASPL GLRTAIEKEG GKKLENDFLS
     SIEMVIVDHA DALIMQNWEH VEYIFSNLNL QPKEAHGCDF SRVRQWYLDG HAKFLRQTLV
     FSAFNTPELN ALYNSQMQNA FGKAKIMPKY DGAILNLRLP ISIKQTFSRF DSLSPLKDPE
     ARFQYFTRTV LANLSRSWTE TSSGKGKLGG TLIFIPSYLD FVRVRNHFAN SSQTANISFG
     LISEYTSVQD SSKARSHFMN GRHSVLLYTE RAHHFRRYNI RGVSNIIMYG LPDNPIFWGE
     VVEYLGTAPG GTTTTPTLRV LFSKWDALKL ERIVGTARVR SMLLEKGGDT FTFV