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UTP25_ASHGO
ID   UTP25_ASHGO             Reviewed;         704 AA.
AC   Q75AX9;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; OrderedLocusNames=ADL209C; ORFNames=AGOS_ADL209C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; AE016817; AAS51711.1; -; Genomic_DNA.
DR   RefSeq; NP_983887.1; NM_209240.1.
DR   AlphaFoldDB; Q75AX9; -.
DR   STRING; 33169.AAS51711; -.
DR   PRIDE; Q75AX9; -.
DR   EnsemblFungi; AAS51711; AAS51711; AGOS_ADL209C.
DR   GeneID; 4620027; -.
DR   KEGG; ago:AGOS_ADL209C; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; Q75AX9; -.
DR   OMA; KYFRQTI; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0019843; F:rRNA binding; IBA:GO_Central.
DR   GO; GO:0034511; F:U3 snoRNA binding; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..704
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408099"
FT   REGION          1..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..47
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..141
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   704 AA;  80742 MW;  8794671C972754D3 CRC64;
     MGITDSHGIM DGKRGRKQLR NITRIGRAIH VQEDEAKSRE EHTVEEAQAG EQTSNRKRGN
     HPAEDDGGAR ESQSYGALLT LLSAEHGKQR KKRLRKAEAE AAEAAEAGED PEEAITAALE
     NSAQDAEDAE DAFDDSGESD EEQDHFDVHF NRVSAADVAQ LDAAFKNGRA QYRVQKEARG
     EEEILYSKPV ASSEGTEGPV RVPARSLRGY AIKQRLRMHN GLTADDPEKP LTPQQKVLLD
     PMFQYQDILY EYEGYDRERE YRELYTLHIL NHVYKTRDRI LKNNQKLQDN PDQELLDQGF
     TRPKALVVVP TRATAYDVVD LLLQQSGIEQ VDKKSKFKDQ FYDPSLPPAS KPKSFQHVFK
     GNTNDFFVLG MKFTRKAIRL YSNFYQSDVI VCSPLGLQLI IENTDKKKRQ DDFLSSIEVM
     VLDQLHSIEF QNIAHVSNIF AHINKIPQQQ RDADFSRIRM WYIEDQAKLF RQTMVFTRYI
     SPFANALLNR KCANWAGRVK SHRVVSAEKS VIGQLGLKLR QIFQRFEVLG GSTVDEPDFR
     FKFFTSVVVP GIEKTTGYDS GILLYIPEYT DFIRVRNYLK DKTRILFGDI NEYSDQRQLT
     SNRALFQLGR IKVLLYTERL HHFRRFELKG VKSVILYKPP SNPEFYQELL RYIGKSAFLG
     VADLNIATVR CLYSKMDSLA LERIVGTKRA AVLTHGQNEV YEFK
 
 
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