ID   UTP25_ASPCL             Reviewed;         693 AA.
AC   A1CQH8;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=utp25; ORFNames=ACLA_026160;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; DS027059; EAW07899.1; -; Genomic_DNA.
DR   RefSeq; XP_001269325.1; XM_001269324.1.
DR   AlphaFoldDB; A1CQH8; -.
DR   STRING; 5057.CADACLAP00001691; -.
DR   EnsemblFungi; EAW07899; EAW07899; ACLA_026160.
DR   GeneID; 4702038; -.
DR   KEGG; act:ACLA_026160; -.
DR   VEuPathDB; FungiDB:ACLA_026160; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   OMA; KYFRQTI; -.
DR   OrthoDB; 257318at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..693
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408100"
FT   REGION          1..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..50
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..72
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..94
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..131
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   693 AA;  78585 MW;  6D9A24CD06106780 CRC64;
     MKRKNGFPSS RVEDIESDDF SEDGVGDDRQ FEDDDMVDEA PEDDVSSESD DEEQQTGRPY
     NELLQLLQAN TESKGPARKK RKVEHNGGEK EDALPPAEDD LEEPESSDEE EDLVEEVDDQ
     DESDDEEDAN DPFDTHFSMV EESELSNAVK AASDKKWKST KKETASGLKL VRSIPDTGEG
     DASLLPPLKN FSSVKLKKKL DGPAADLIPA MSDDAQQLAP YIFGYQDVLH GARNTSNSAT
     LRDLLAIHAT NHVLKTRDRV LKNNARVAKE QDADLDLRDQ GFTRPKVLYL LPTRQACVRV
     VDSITRCFQP EQQENKKRLL DTFSRPDDKS WETKPEDFRE LFGGNDDDMF RLGLKFTRKT
     IKYFAQFYNS DMILASPLGL RTIMDQADAK KRDHDFLSSI EVVIVDHADA LLMQNWDHID
     YILNHLNLQP RQAHGCDFSR VRTWYLDNQA RSVRQMIMTT AFITPEMNSV FSTHMQNYAG
     KIKATPVYAG AISEVPLPVS VKQTFSRFDS LTPTKDPDAR FKHFTTTVLS SLVRNITSSR
     DKSSVGGTLI FIPSYLDFVR VRNHFATSAQ TTNVSFGAIS EYTDVREMSR ARTHFMNGRH
     SVLLYTERLH HFRRYRIRGV KRIVMYGMPE NPLFWGEIVS FLGLDEAGVV EAAEGGVRAL
     FSKWDALKLE RIVGTKRVGN MLREKGGDTF TFV