ID   UTP25_ASPFC             Reviewed;         671 AA.
AC   B0XQ54;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=utp25; ORFNames=AFUB_008740;
OS   Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS   fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=451804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; DS499594; EDP56168.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0XQ54; -.
DR   EnsemblFungi; EDP56168; EDP56168; AFUB_008740.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   PhylomeDB; B0XQ54; -.
DR   Proteomes; UP000001699; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Ribonucleoprotein; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..671
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408101"
FT   REGION          1..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..63
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..109
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   671 AA;  76208 MW;  ACB286922BA6AD6A CRC64;
     MDHETQMDDV LSDSDDDEDQ QTARPYNELI QLLQVNTEPK GPARKRRKVE YNGGEKRDFV
     PAANGEEVDA ALQGDDDLQE QEPSDEEEED HPEEADGNHG SDDEEDANDP FETHFSAIDE
     NKLALKIKSA EEKKWKNAKK EISSGLKLVR AIPDVGEGDV SLLPAMKHFS SVKLKKKLCG
     PATERIPEIS GDAQHIAPYI FNYQDVLYGA RTTSNSSAMR DILAVHAVNH ILKTRDRVLK
     NNSRIAKEQD ADLDLRDQGF TRPKVLYLLP TRQACVRAVE SITRFFQPEQ QENKKRFLDS
     FSAADDKSWE NKPEDFRELF GGNDDDMFRL GLKFTRKTMK YFSQFYNSDI ILASPLGLRT
     IMDQADVKKR DHDFLSSVEL VIVDHADALL MQNWDHVGYI LDRLNLQPKE AHGCDFSRVR
     TWYLDNHARF VRQMIVSASF ITPEINSLFS THMQNFAGKV KVTPVYVGAI SEVPLPVSVK
     QTFSRFDSLT PTKDPDARFK HFTTTVLSSL VRNITSSRDK SSAGGTLIFI PSYLDFVRVR
     NYFATSSQTT NVSFGAISEY SEVREMTRAR THFMNGRHAV LLYTERLHHF RRYQLRGVKR
     IVMYGVPENP LFWGEIVGFL GLDPAGVVDA AEGGVRALFS KWDALKLERI VGTKRVGNML
     REKGGDTFTF V