UTP25_ASPFU
ID UTP25_ASPFU Reviewed; 671 AA.
AC Q4WTH1;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE Short=U3 snoRNA-associated protein 25;
DE AltName: Full=U three protein 25;
GN Name=utp25; ORFNames=AFUA_1G09320;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAHF01000004; EAL90261.1; -; Genomic_DNA.
DR RefSeq; XP_752299.1; XM_747206.1.
DR AlphaFoldDB; Q4WTH1; -.
DR STRING; 746128.CADAFUBP00000858; -.
DR EnsemblFungi; EAL90261; EAL90261; AFUA_1G09320.
DR GeneID; 3510210; -.
DR KEGG; afm:AFUA_1G09320; -.
DR eggNOG; KOG2340; Eukaryota.
DR HOGENOM; CLU_018705_0_1_1; -.
DR InParanoid; Q4WTH1; -.
DR OMA; KYFRQTI; -.
DR OrthoDB; 257318at2759; -.
DR Proteomes; UP000002530; Chromosome 1.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IBA:GO_Central.
DR GO; GO:0034511; F:U3 snoRNA binding; IBA:GO_Central.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010678; UTP25.
DR PANTHER; PTHR12933; PTHR12933; 1.
DR Pfam; PF06862; UTP25; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..671
FT /note="U3 small nucleolar RNA-associated protein 25"
FT /id="PRO_0000408102"
FT REGION 1..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..109
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 671 AA; 76208 MW; ACB286922BA6AD6A CRC64;
MDHETQMDDV LSDSDDDEDQ QTARPYNELI QLLQVNTEPK GPARKRRKVE YNGGEKRDFV
PAANGEEVDA ALQGDDDLQE QEPSDEEEED HPEEADGNHG SDDEEDANDP FETHFSAIDE
NKLALKIKSA EEKKWKNAKK EISSGLKLVR AIPDVGEGDV SLLPAMKHFS SVKLKKKLCG
PATERIPEIS GDAQHIAPYI FNYQDVLYGA RTTSNSSAMR DILAVHAVNH ILKTRDRVLK
NNSRIAKEQD ADLDLRDQGF TRPKVLYLLP TRQACVRAVE SITRFFQPEQ QENKKRFLDS
FSAADDKSWE NKPEDFRELF GGNDDDMFRL GLKFTRKTMK YFSQFYNSDI ILASPLGLRT
IMDQADVKKR DHDFLSSVEL VIVDHADALL MQNWDHVGYI LDRLNLQPKE AHGCDFSRVR
TWYLDNHARF VRQMIVSASF ITPEINSLFS THMQNFAGKV KVTPVYVGAI SEVPLPVSVK
QTFSRFDSLT PTKDPDARFK HFTTTVLSSL VRNITSSRDK SSAGGTLIFI PSYLDFVRVR
NYFATSSQTT NVSFGAISEY SEVREMTRAR THFMNGRHAV LLYTERLHHF RRYQLRGVKR
IVMYGVPENP LFWGEIVGFL GLDPAGVVDA AEGGVRALFS KWDALKLERI VGTKRVGNML
REKGGDTFTF V