ID   UTP25_ASPNC             Reviewed;         721 AA.
AC   A2QQ09;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=utp25; ORFNames=An08g00870;
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=425011;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA   Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA   van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA   Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA   Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA   Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA   Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA   Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; AM270157; CAK45239.1; -; Genomic_DNA.
DR   RefSeq; XP_001392205.1; XM_001392168.1.
DR   AlphaFoldDB; A2QQ09; -.
DR   PaxDb; A2QQ09; -.
DR   PRIDE; A2QQ09; -.
DR   EnsemblFungi; CAK45239; CAK45239; An08g00870.
DR   GeneID; 4982401; -.
DR   KEGG; ang:ANI_1_118074; -.
DR   VEuPathDB; FungiDB:An08g00870; -.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   Proteomes; UP000006706; Chromosome 8R.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..721
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408103"
FT   REGION          1..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..36
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..69
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        93..114
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..161
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   721 AA;  81635 MW;  DFA8F68681E49D95 CRC64;
     MAPPRGRAPR GRGKRSRGPV GRRDAFQASR VDDIESDDSS SGEDGPIDEH MEEGMAEEEA
     MDVGSSSDEE DEEKSGRPYN ELLQLLNTST DSKGPARKKR KVEHKNTETI EVVREDPVAE
     EDEEALGEDD LEQQEPSDEE DNGNQEDAGA QDSDDEDDND PFDTHFTNPT EDELAKKIKA
     IGENKWKNAK KELPEGLRLV RAVPDTGDDA SWLPPMKQIS SVKLKRKLKE PASDKFPQIS
     GQAQHIAPYI FGYQDVLYGA RTPSNSAQMR DLLALHATNH VLKTRDRVLK NNTRLAKEQD
     SDLDVRDQGF TRPKVLYLLP TKQACVRAVE SITRFFQPEQ QENKKRLLDT FSAADDPSWE
     SKPDDFRELF GGNDDDMFRL GLKFTRKTVK YFAQFYTSDI IMASPLGLRT IMDQADVKKR
     DHDFLSSIEV VIVDHADALL MQNWDHIDYI MKHLNLQPRE AHGCDFSRVR TWYLDNNARY
     VRQMIMLTSF VTPEMNSVFS THMHNTSGKV KATPIHAGAI TELPLPVSVR QTFTRFDCLS
     PAKDPDARFK HFTTTILSSL VRDIASGRGK ASAGGTLIFI PSYLDFVRVR NHFATSQQTT
     NVSFGAISEY TEQREASRAR SYFMNGRQSV LLYTERLHHF RRYQLRGVKR IIMYGVPENP
     AFYSEIVGFL GLDPAALVEA AEGGVRALFS KWDALKLERI VGTQRVGNMM REKGGDTFTF
     M