ID   UTP25_BLAGS             Reviewed;         731 AA.
AC   C5JMX0; A0A179UKV4;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 2.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=BDBG_03882;
OS   Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX   NCBI_TaxID=559298;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SLH14081;
RX   PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA   Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA   Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA   Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA   Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA   Clay O.K., Klein B.S., Cuomo C.A.;
RT   "The dynamic genome and transcriptome of the human fungal pathogen
RT   Blastomyces and close relative Emmonsia.";
RL   PLoS Genet. 11:E1005493-E1005493(2015).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; GG657453; OAT07859.1; -; Genomic_DNA.
DR   AlphaFoldDB; C5JMX0; -.
DR   SMR; C5JMX0; -.
DR   STRING; 559298.C5JMX0; -.
DR   EnsemblFungi; OAT07859; OAT07859; BDBG_03882.
DR   VEuPathDB; FungiDB:BDBG_03882; -.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   Proteomes; UP000002038; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..731
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408095"
FT   REGION          1..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..49
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..76
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        103..124
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        125..167
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   731 AA;  82216 MW;  B8F18671EB5B3E9C CRC64;
     MVAPRGRGSR PFNSRGARGG RGRGQRGGRK PRFETSRVEE VHHEASSDGE SGLSEGNVDA
     EDEVELIDEL SSGSDDDDEE DKKTSKPYNT LLQLFNAGQD TNGPARKRRK VEHSSKKTEV
     QIKEPEELDD EADLSESEIE DDEEDEDAEG IAVDEGEAED SGDEDDATDP FETHFSNVDS
     SLLLQKINVI STKGWKTHKN ELPGKFRLVL SHPDTGGDAV QLPPPAHGLQ SLKLKQKLAN
     HAGDHIAKFE SLTSGLVPYI FGYQDLLFGA RTLSNSAKFR DLYCLHVLNH ILKTRDRVLK
     NNSRSQKEPD QDLELRDQGF TRPKVLIILP TRQACVRVVE SITKLYHAEQ QENKSRFYDT
     FSAADDKSWE DKPDDFRELF GGNDDDMFRL GLKFTRKTIK YFSQFYNSDI ILASPLGLRM
     VMDKEDGKKQ DFDFLSSIEV AVVDQADALL MQNWEHIEYV FSHLNLQPKE SHGCDFSRVR
     NWYLDGQAKY VRQTLVFSSF ITPEINALFS SQMHNTAGKV KVTPTYEGAI LDIPLPVPVK
     QTFSRFNSTS PVKDPDDRFK YFTSAVLSSL VRSSTGSGGK PHASGTLIFI PSYLDFVRVR
     NYLATSSQTE NLSFGAISEY TSVRDVARAR THFFSGRHSA LLYTERTHHF RRYQIRGVKR
     VIMYGVPENP VFWGEIVGFL GLDPAGTAEA AEGGVRALFS KWDALKMERI VGTKRLGNML
     MEKGGDTFSF V