ID   UTP25_CANAL             Reviewed;         716 AA.
AC   Q59MU1; A0A1D8PTB0;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; OrderedLocusNames=CAALFM_CR06840WA;
GN   ORFNames=CaO19.1849, CaO19.9407;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; CP017630; AOW31381.1; -; Genomic_DNA.
DR   RefSeq; XP_711078.2; XM_705986.2.
DR   AlphaFoldDB; Q59MU1; -.
DR   STRING; 237561.Q59MU1; -.
DR   PRIDE; Q59MU1; -.
DR   GeneID; 3647322; -.
DR   KEGG; cal:CAALFM_CR06840WA; -.
DR   CGD; CAL0000179907; orf19.9407.
DR   VEuPathDB; FungiDB:CR_06840W_A; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; Q59MU1; -.
DR   OrthoDB; 257318at2759; -.
DR   PRO; PR:Q59MU1; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0019843; F:rRNA binding; IBA:GO_Central.
DR   GO; GO:0034511; F:U3 snoRNA binding; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..716
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408107"
FT   REGION          1..167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..44
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..68
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..152
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   716 AA;  82950 MW;  CCD0A8210666A623 CRC64;
     MAKQFKRKSN GVSESNRKRG RQELRKVTRT AARKQQQDEN HEDDLNVNND SEEDNSGKEI
     DEEDEEGERD DNRGKAYSAL LTLLKSEHKE KPKNVTFGSS SQVEKANASD SEDDGIAGAN
     VDEEEEEGEI DNNVDENEIV SESDDDDDED ATNRLSTDPF ESHFNLPSDD YLAKEEKLVL
     KDNEKWRTVD KQTYSDLAIS SLVQLPPGEP LNPPLLKSSK LSEYTIKKRV LDSYEQAYGT
     GLSDLESTLI NPILNYRDVN FQYKSFKNKF YRRLYTLHAL NHIFKTRDRI LKNTAKLHAA
     KEDSEELELR DQGFTRPKVL IMLPTRDACY EVVEQLIKLS GTEQQENKKK FNDQFYVKAT
     PPATKPEDFR DAFKGNNNDF FCIGLKFTRK SLKLYSSFYS SDIILASPIG LSMILENPDK
     KKRQYDFLSS IEVLIVDKCN QIEMQNWDHV NTVMKYLNKV PKEFHDADFS RIRMWSINDQ
     AKLLRQTLVF CEYLTPSINN LISSKSYNLS GKVKFKPIIN SENSMMNSIG LKIKQIFQRF
     DSQSPLQDPD SRYKYFINAI LPSLLKTSSY EDGIMIFIPS YFDYLRVKNY LKTSTKFTFG
     SIDEYSSQSK LTKTRQEFAS GKIKLLLYTE RLHYFRRYEI SGVKTLIMYG LPSNPLFYKE
     LIRFIGKSVF KEECDLDLAL VKILFSKWDA VNLEKIVGNE RAPVLCNSMN ELYEFR