ID   UTP25_CANAW             Reviewed;         716 AA.
AC   C4YMA4;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=CAWG_01983;
OS   Candida albicans (strain WO-1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294748;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WO-1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM000309; EEQ43735.1; -; Genomic_DNA.
DR   AlphaFoldDB; C4YMA4; -.
DR   STRING; 5476.C4YMA4; -.
DR   PRIDE; C4YMA4; -.
DR   EnsemblFungi; EEQ43735; EEQ43735; CAWG_01983.
DR   VEuPathDB; FungiDB:CAWG_01983; -.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   OMA; LYTERWH; -.
DR   Proteomes; UP000001429; Chromosome R.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Ribonucleoprotein; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..716
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408108"
FT   REGION          1..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..68
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..152
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   716 AA;  82977 MW;  E7F4C2C824AA6CED CRC64;
     MAKQFKRKSN GVSESNRKRG RQELRKVTRT AARKQQQDEN HEDDLDVNND SQEDNSEKEI
     DEEDEEGERD DNRGKAYSAL LTLLKSEHKE KPKNVTSGSS SQVEKANASD SEDDGIAGAN
     VEEEEEGEID NNVDENEIVS ESDVDDDDED ATNRLSTDPF ESHFNLPSDD YLAKEEKLVL
     KDNEKWRTVD KQTYSDLAIS SLVQLPPGEP LNPPLLKSSK LSEYTIKKRV LDSYEQAYGT
     DLSDLESTLI NPILNYRDVN FQYKSFKNKF YRRLYTLHAL NHIFKTRDRI LKNTAKLHAA
     KEDSEELELR DQGFTRPKVL IMLPTRDACY EVVEQLIKLS GTEQQENKKK FNDQFYVKAT
     PPATKPEDFR DAFKGNNSDF FCIGLKFTRK SLKLYSSFYS SDIILASPIG LSMILENPDK
     KKRQYDFLSS IEVLIVDKCN QIEMQNWDHV NTVMKYLNKV PKEFHDADFS RIRMWSINDQ
     AKLLRQTLVF CEYLTPSINN LISSKSYNLS GKVKFKPIIN SENSMMNSIG LKIKQIFQRF
     DSQSPLQDPD SRYKYFINAI LPSLLKTSSY EDGIMIFIPS YFDYLRVKNY LKTSTKFTFG
     SIDEYSSQSK LTKTRQEFAS GKIKLLLYTE RLHYFRRYEI SGVKTLIMYG LPSNPLFYKE
     LIRFIGKSVF KEECDLDLAL VKILFSKWDA VNLEKIVGNE RAPVLCNSMN ELYEFR