ID   UTP25_CANDC             Reviewed;         712 AA.
AC   B9WM88;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=CD36_32380;
OS   Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 /
OS   NRRL Y-17841) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=573826;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841;
RX   PubMed=19745113; DOI=10.1101/gr.097501.109;
RA   Jackson A.P., Gamble J.A., Yeomans T., Moran G.P., Saunders D., Harris D.,
RA   Aslett M., Barrell J.F., Butler G., Citiulo F., Coleman D.C.,
RA   de Groot P.W.J., Goodwin T.J., Quail M.A., McQuillan J., Munro C.A.,
RA   Pain A., Poulter R.T., Rajandream M.A., Renauld H., Spiering M.J.,
RA   Tivey A., Gow N.A.R., Barrell B., Sullivan D.J., Berriman M.;
RT   "Comparative genomics of the fungal pathogens Candida dubliniensis and
RT   Candida albicans.";
RL   Genome Res. 19:2231-2244(2009).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; FM992695; CAX40201.1; -; Genomic_DNA.
DR   RefSeq; XP_002422197.1; XM_002422152.1.
DR   AlphaFoldDB; B9WM88; -.
DR   STRING; 42374.XP_002422197.1; -.
DR   PRIDE; B9WM88; -.
DR   EnsemblFungi; CAX40201; CAX40201; CD36_32380.
DR   GeneID; 8049346; -.
DR   KEGG; cdu:CD36_32380; -.
DR   CGD; CAL0000162760; Cd36_32380.
DR   VEuPathDB; FungiDB:CD36_32380; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   OrthoDB; 257318at2759; -.
DR   Proteomes; UP000002605; Chromosome R.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Ribonucleoprotein; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..712
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408109"
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          85..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..47
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..67
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..144
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   712 AA;  82588 MW;  65958EF502B89DFA CRC64;
     MAKQFKRKSN GVSENNRKRG RQELRKVTRT AARKQQDESH EDGLDVNNNF EEDNAEEEID
     EEEVGEQDYD DRGKAYSALL TLLKSEHKEK SKNVTSGSLQ VDRTNPSDSE DEEIAGANVE
     EDENEGEDEN VDENGIDSES DNEDEDTVNR LSTDPFESHF NLPTEDYLAK EEKLVLKDNE
     KWCTVDKRTY SDLAVTSLVQ LPPGEPINPP LLKSSKLNEY TIKKRVLDSY QQAYGAELTD
     LESTLINPIL NYRDVNFQYK SFKNKSYRKL YTLHALNHIF KTRDRILKNT AKLHAAKEDS
     EELELRDQGF TRSKVLIMLP TRDSCYEVVE QLIKLSGTEQ QENKKKFNDQ FYVKAAPPAN
     KPDDFRDAFK GNNSDFFCIG LKFTRKSLKL YSSFYSSDII LASPIGLSMI LENPDKKKRQ
     YDFLSSIEVL IVDRCNQIEM QNWDHVNTVM KYVNKVPKEF HDADFSRIRM WSINDQAKLL
     RQTLVFCEYL TPSINNLISS KSHNLSGKVK FKPIINSENS MMNSIGLKIK QIFQRFDSQS
     PLQDPDARYK YFINAILPSL LKTSSYEDGI MIFIPSYFDY LRVKNYLKTS TKFTFGSIDE
     YSSQSKLTKT RQEFASGKIK LLLYTERLHY FRRYEISGVK TLIMYGLPSN PLFYKELIRF
     IGKSVFKEEC DLDLALVKIL FSKWDAVNLE KMVGNERAPV LCNSMNELYE FR