ID   UTP25_CANGA             Reviewed;         700 AA.
AC   Q6FVZ6;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; OrderedLocusNames=CAGL0D04180g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; CR380950; CAG58509.1; -; Genomic_DNA.
DR   RefSeq; XP_445598.1; XM_445598.1.
DR   AlphaFoldDB; Q6FVZ6; -.
DR   STRING; 5478.XP_445598.1; -.
DR   PRIDE; Q6FVZ6; -.
DR   EnsemblFungi; CAG58509; CAG58509; CAGL0D04180g.
DR   GeneID; 2887158; -.
DR   KEGG; cgr:CAGL0D04180g; -.
DR   CGD; CAL0128371; CAGL0D04180g.
DR   VEuPathDB; FungiDB:CAGL0D04180g; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; Q6FVZ6; -.
DR   OMA; LYTERWH; -.
DR   Proteomes; UP000002428; Chromosome D.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR   GO; GO:0019843; F:rRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..700
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408110"
FT   REGION          1..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..58
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..83
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..130
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   700 AA;  81426 MW;  9203D5711511A9E6 CRC64;
     MDKRGRKELR SIRRAKRTKI EPEADAGVES SGSVLEAGPA VEEKVQDDGE KEDDKEQVYN
     ALLTILKSEH KEDKVKTHRD HDEEESEAEE EEQAEDQYND AFADGESDDE DDDEDEQAQE
     QEEIESDDEE KDPFDTHFNG EEAAKHGEAL GNALKDNKLR YKSIKLKVGS ADEDQVQEDA
     IFSVPYIEGE TPKIEDPKLK CSLSSYFLKK RLRIQNNLLD TESNALTDLQ RKIVDPMMQY
     KDILYEYDTY GKDEDEYRDL YTLHVLNHVY KTRDKIIKNN QKLQDNPDSE FLDQGFTRPK
     VLIIAPTRDS AYQIVTKLIE KSGLDQVDKK GKFRDQFYDP SFPPSSKPKS FQHIFKGNTN
     DYFVLGVKFT RKAIKLYSNF YQSDIIVCSP LGLQMIVENT DKKKRQDDFL SSVEVTIIDQ
     FHSIEYQNYT HLFTIFDHLN KIPQEQHDAD FSRIRMWYIN DQAKFFRQTM IFTKYISPVA
     NSLLNIKCRN LEGRWKNHKI VSSEDSSVGT VGLKVRQIFQ RFNVLGNSVA DEPDYRFKFF
     TSVVISNITK STGYDDGTLI YIPEYSDYVR VRNYMKEKTS ILFGDINEYS EQRSLTSNRT
     LFNQGRLKVL LYTERLHHFR RYELKGVKNV VFYKPPSDPE FYKEVVRYIG KTVFLGDADL
     NISTVRCCYS KLDGLALEKI VGTKRTGVLT HGQNETYEFK