ID   UTP25_CANTT             Reviewed;         710 AA.
AC   C5M3P0;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=CTRG_00679;
OS   Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-3404 / T1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; GG692395; EER35940.1; -; Genomic_DNA.
DR   RefSeq; XP_002545898.1; XM_002545852.1.
DR   AlphaFoldDB; C5M3P0; -.
DR   STRING; 5482.XP_002545898.1; -.
DR   PRIDE; C5M3P0; -.
DR   EnsemblFungi; EER35940; EER35940; CTRG_00679.
DR   GeneID; 8296893; -.
DR   KEGG; ctp:CTRG_00679; -.
DR   VEuPathDB; FungiDB:CTRG_00679; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   OrthoDB; 257318at2759; -.
DR   Proteomes; UP000002037; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR   GO; GO:0019843; F:rRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..710
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408111"
FT   REGION          1..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..63
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        88..107
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        108..139
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   710 AA;  82456 MW;  1D0E9F386428F351 CRC64;
     MAKQVKRKSS GITKPDGNRK RGRSEMRTVT RTAARKPRDE EQDDDSSDHS EEEAVHQSNG
     DDYEDTDGEN DEDEDSGKAY SALLTLLKTD NKEKKEKPES FSIEEKDQPS EDENEVAGVV
     SDNENEDENE EDQQISDNEE EEEVKGLASD PFEVHFNLPS DDYLNKEEKL VLKDHEKWPI
     VDKKTYADLA LTSMLQLPPG EQIEPPLLKS TKLKDYAIKK RVLDSYEKAY GLDLTETDSL
     IANSILNYRD VNYQYKTFTN KNYRRIYVMH ALNHIYKTRD RILKNTTKLH VHKESSNDED
     LEFRDQGFTR PKVLIMLPTR NSCYEVVEQL IKLSGTDQQE NKKKFNDQFY AKAAPPNNKP
     EDFKDAFKGN NSDFFCIGLK MTRKSLKLYS SFYSSDIILA SPIGLSMILE NPDKKKRQYD
     FLSSIEVLIV DKSNQIEMQN WDHVNTVMNY INKVPKEFHD ADFSRIRMWS INDQARLLRQ
     TLVFCEYLTP SINNLVSSKS FNLSGKVKFK PIINSEKSMM NSIGLKIKQI FQRFESGSPV
     QDPDARFKFF INTILPSLLK TSSYEDGIMI FIPSYFDYLR VKNYLKTSTK FDFGSIDEYT
     SQSKLTRTRQ GFASGKIKLI LYTERLHYFR RYEISGVKTL IMYGLPSNPL FYKELIRFIG
     KSVFKEECEL DLALVKILFS KWDAVNLEKI VGNERAPILC NSMNELYEFR