ID   UTP25_CHAGB             Reviewed;         723 AA.
AC   Q2HGJ1;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25;
DE            Short=U3 snoRNA-associated protein 25;
DE   AltName: Full=U three protein 25;
GN   Name=UTP25; ORFNames=CHGG_00663;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: DEAD-box RNA helicase-like protein required for pre-18S rRNA
CC       processing, specifically at sites A0, A1, and A2. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome
CC       composed of at least 40 protein subunits and snoRNA U3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP25 family. {ECO:0000305}.
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DR   EMBL; CH408029; EAQ92428.1; -; Genomic_DNA.
DR   RefSeq; XP_001219884.1; XM_001219883.1.
DR   AlphaFoldDB; Q2HGJ1; -.
DR   STRING; 38033.XP_001219884.1; -.
DR   EnsemblFungi; EAQ92428; EAQ92428; CHGG_00663.
DR   GeneID; 4386694; -.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_0_1_1; -.
DR   InParanoid; Q2HGJ1; -.
DR   OMA; KYFRQTI; -.
DR   OrthoDB; 257318at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; PTHR12933; 1.
DR   Pfam; PF06862; UTP25; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..723
FT                   /note="U3 small nucleolar RNA-associated protein 25"
FT                   /id="PRO_0000408112"
FT   REGION          1..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..64
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..90
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..123
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..175
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   723 AA;  81629 MW;  35A8BD11D599F8B8 CRC64;
     MAPGGRAGFR GGSSRGGPSR GGTRGRGSSR GRGRGRGRAV AQQPRGARFD DKRLASKDES
     ESEAGSESPS DDESDAMEVD SNEEDEEETQ SAQPYLSLMR SLVESAPKAK RRKLDHASAE
     RQGPESTKPE AAPEATDGEE DGDEDGEERD VDFVEEPEED PTNAAPEDLF DEDDDLDVSD
     PFEVHFADPK EEVLRPRLEA IQGNKWRMER IAANSTRVFF NTPDAGDAAA KPLPAPISGI
     SDLKLKKRLQ EAMAPKHAKF DQVEQTIAPL LFNYQDMLYC NRTVAGSQGI RRMASLHALN
     HVFKADGNED LELRDQGFTR PKVLMLLPTR QSCVKMVDMI VSICEPDQQE NRKRFEDGYI
     DKQSKFSDDK PDDFKDLFSG SDDDMFRLGM KFTRKTIKYF SQFYNSDIIF ASPLGLRMAI
     GSEEEKKLDF DFLSSIELVI VDQADALLMQ NWEHVEFIFE HLNVQPKDAH GCDFSRVRSW
     YLDDQAKHFR QTVIFSAFNT PELVELLRTH CHNWAGKARL QQESAGTIQH LPVKARQTFS
     RFEAGSIAAD PDARFAYFTK AIVPMLARHR GRDAAGTLVF IPSYLDFVRV RNYFANNPAV
     ENVSFGTISE YADVPEASRA RSHFLNGRHK VLLYTERAHH FRRYQIKGVK RVVMYALPDN
     PLFYQEIAGG YLQKSEQSLL VEHGQGVVRV MFSKYDVMKL ERIVGTSRVG KMIHDQGDTF
     DFV